Immunomodulation by Small Molecules for Prevention Or Treatment of Cancer PDF Download
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Author: Di Zhang
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 246
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Book Description
Cancer is the second leading cause of deaths worldwide. Lung cancer and breast cancer, specifically, are two of the most common cancers in the U.S. except skin cancer. With the increasing medical and economic burden of these diseases, developing effective cancer prevention and treatment strategies is important and urgent. Cancer is characterized by uncontrolled cell proliferation. Targeting the tumor cells directly to inhibit their growth and increase cell death has been the major focus of cancer treatment since the last century. Cancer is also described as a wound that does not heal. Inflammation plays critical roles in cancer development and progression. The immune system is a powerful host defense mechanism against infections and diseases including cancer. However, tumor cells are able to edit and suppress the immune system to evade the immune attack. Targeting immune cells to unleash the power of immune surveillance has become a research priority. The recent breakthroughs in cancer immunotherapy have revolutionized the landscape of cancer treatment. As immunotherapy becomes the first line of therapy in cancer treatment, it is essential to understand how other drugs modulate the immune system, so that we can deliver more effective and less toxic combinations. In this thesis project, I focused on four therapeutic targets (bromodomain proteins, retinoid X receptors, Nrf2 transcription factors, poly (ADP-ribose) polymerase) and explored their effects on the immune cells. Small molecules targeting these proteins were tested in various preclinical mouse models in the context of either cancer prevention or treatment. My studies not only demonstrated enhanced efficacy and reduced toxicity with all four classes of compounds but also provided some novel insights into the immunomodulatory effects of these clinically relevant signaling pathways. This work is highly translational and could have direct impact on human patients.
Author: Di Zhang
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 246
Get Book Here
Book Description
Cancer is the second leading cause of deaths worldwide. Lung cancer and breast cancer, specifically, are two of the most common cancers in the U.S. except skin cancer. With the increasing medical and economic burden of these diseases, developing effective cancer prevention and treatment strategies is important and urgent. Cancer is characterized by uncontrolled cell proliferation. Targeting the tumor cells directly to inhibit their growth and increase cell death has been the major focus of cancer treatment since the last century. Cancer is also described as a wound that does not heal. Inflammation plays critical roles in cancer development and progression. The immune system is a powerful host defense mechanism against infections and diseases including cancer. However, tumor cells are able to edit and suppress the immune system to evade the immune attack. Targeting immune cells to unleash the power of immune surveillance has become a research priority. The recent breakthroughs in cancer immunotherapy have revolutionized the landscape of cancer treatment. As immunotherapy becomes the first line of therapy in cancer treatment, it is essential to understand how other drugs modulate the immune system, so that we can deliver more effective and less toxic combinations. In this thesis project, I focused on four therapeutic targets (bromodomain proteins, retinoid X receptors, Nrf2 transcription factors, poly (ADP-ribose) polymerase) and explored their effects on the immune cells. Small molecules targeting these proteins were tested in various preclinical mouse models in the context of either cancer prevention or treatment. My studies not only demonstrated enhanced efficacy and reduced toxicity with all four classes of compounds but also provided some novel insights into the immunomodulatory effects of these clinically relevant signaling pathways. This work is highly translational and could have direct impact on human patients.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309180686
Category : Medical
Languages : en
Pages : 102
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Book Description
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Author: Brian A. Baldo
Publisher: Springer
ISBN: 3319304720
Category : Medical
Languages : en
Pages : 623
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Book Description
This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.
Author: Iris F. F. Benzie
Publisher: CRC Press
ISBN: 1439807167
Category : Health & Fitness
Languages : en
Pages : 500
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Book Description
The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
Author: Eckhard Ottow
Publisher: Wiley-VCH
ISBN: 9783527318728
Category : Medical
Languages : en
Pages : 522
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Book Description
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
Author: Keith Block
Publisher: Bantam
ISBN: 0553801147
Category : Health & Fitness
Languages : en
Pages : 610
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Book Description
Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.
Author: Peter L. Stern
Publisher: Cambridge University Press
ISBN: 9780521622639
Category : Medical
Languages : en
Pages : 304
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Book Description
Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.
Author: Bharat B. Aggarwal
Publisher: Springer
ISBN: 3034808372
Category : Medical
Languages : en
Pages : 489
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Book Description
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author: Fazlul H. Sarkar
Publisher: Springer Science & Business Media
ISBN: 9400726309
Category : Medical
Languages : en
Pages : 383
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Book Description
This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
Author: Piyush Kumar
Publisher: Springer
ISBN: 3319458264
Category : Technology & Engineering
Languages : en
Pages : 77
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Book Description
This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.
