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Author: A. Henneberg
Publisher: Karger Medical and Scientific Publishers
ISBN: 9783805563840
Category : Medical
Languages : en
Pages : 132
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Book Description
In addition, fundamental questions concerning the bi-directional interactions between the central nervous system and the immune system are discussed and the role of viruses and infectious processes closely examined. As such, this book offers a unique presentation of the state of the art in psychoimmunology and, at the same time, shows many important challenges for future research into the field of intersystemic interactions and their impact on the etiology and pathogenesis of psychiatric diseases.
Author: A. Henneberg
Publisher: Karger Medical and Scientific Publishers
ISBN: 9783805563840
Category : Medical
Languages : en
Pages : 132
Get Book
Book Description
In addition, fundamental questions concerning the bi-directional interactions between the central nervous system and the immune system are discussed and the role of viruses and infectious processes closely examined. As such, this book offers a unique presentation of the state of the art in psychoimmunology and, at the same time, shows many important challenges for future research into the field of intersystemic interactions and their impact on the etiology and pathogenesis of psychiatric diseases.
Author: A. Henneberg
Publisher:
ISBN: 9783318002218
Category : Medical
Languages : en
Pages : 0
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Book Description
During the past three decades psychiatric research has made use of the expertise and techniques of many medical disciplines, among them neuroendocrinology, immunology, virology, genetics, and molecular biology. This book provides a concise overview of our present knowledge on the immunological aspects of psychiatric diseases, in particular schizophrenia, drug addiction and Alzheimer's disease. In addition, fundamental questions concerning the bi-directional interactions between the central nervous system and the immune system are discussed and the role of viruses and infectious processes closely examined. As such, this book offers a unique presentation of the state of the art in psychoimmunology and, at the same time, shows many important challenges for future research into the field of intersystemic interactions and their impact on the etiology and pathogenesis of psychiatric diseases. Psychiatrists and neurologists will gain a better understanding of the biological basis of psychiatric diseases while immunologists, neuroimmunologists, neurobiologists, neuroendocrinologists and virologists will find it a valuable source of new information on psychoimmunology research.
Author: Antonio L. Teixeira
Publisher: Oxford University Press
ISBN: 0190884479
Category : Science
Languages : en
Pages : 304
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Book Description
In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.
Author: Michael Berk
Publisher: Springer Nature
ISBN: 303071229X
Category : Medical
Languages : en
Pages : 438
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Book Description
This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.
Author: Norbert Müller
Publisher: Springer
ISBN: 331913602X
Category : Medical
Languages : en
Pages : 408
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Book Description
Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
Author: Błażej Misiak
Publisher: Frontiers Media SA
ISBN: 2889457974
Category :
Languages : en
Pages : 115
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Book Description
Major psychiatric disorders, including schizophrenia, bipolar disorder and major depression represent complex phenotypes with imprecise diagnostic boundaries. It has been found that these disorders can be characterized by a number of peripheral immune-inflammatory alterations, including, i.e. elevated levels of pro-inflammatory cytokines, increased levels of specific and non-specific antibodies or abnormal counts of lymphocyte subpopulations. Although it has been found that major psychiatric disorders share similar dysregulations of immune-inflammatory response, recent studies have also clearly demonstrated that some differences can be indicated. Interestingly, certain immune-inflammatory disturbances appear to be state markers, since they occur in acute relapse and normalize following pharmacological treatment, while the rest represents trait markers that remain stable regardless of treatment. It is also important to note that peripheral immune-inflammatory markers have been associated with psychopathological manifestation of major psychiatric disorders, response to treatment and long-term outcomes. However, it remains unclear what is the origin of peripheral inflammation in psychiatric disorders. To date, several mechanisms have been proposed, including the gut-brain axis dysregulation, infections in the neurodevelopmental period or immunogenetic factors. This eBook summarizes current evidence from studies investigating peripheral inflammation in schizophrenia, bipolar disorder, major depression and post-traumatic stress disorder as well as it provides future directions for the field.
Author: Hymie Anisman
Publisher: Academic Press
ISBN: 0128113529
Category : Medical
Languages : en
Pages : 700
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Book Description
The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson’s and Alzheimer’s-like dementia are explored. Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health
Author: Marion Leboyer
Publisher: Frontiers Media SA
ISBN: 2889660567
Category : Medical
Languages : en
Pages : 124
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Book Description
Author: Gerhard Wieselmann
Publisher: Springer Science & Business Media
ISBN: 3709168708
Category : Medical
Languages : en
Pages : 164
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Book Description
This book tries to close the gap between immunological findings on the one hand, psychological, psychopathological, electrophysiological and neuroimaging aspetcs on the other. It deals with the issue of "cause and effect” (of immunological alternatives) in different organic and/or mental disorders, and emphasizes the necessity of considering a variety of treatment strategies. There are dynamic interactions and several important similarities between the immune system and the central nervous system, which help to lay the rational basis for "psychoimmunology”. Both systems have the capacity for memory and both play vital roles in adaptation and defence. Furthermore, in each system pathological changes can occur in the event of inappropriate responses to internal or external stimuli, leading to psychiatric as well as organic illnesses and autoimmune diseases could also arise as a consequence of dysfunction respectively maladaptation. "... this book is a good way to approach the field of psychoimmunology, and shows that scientists are very active in this domain ...” Acta Neurologica Belgica.
Author: Allan Siegel
Publisher: Springer Science & Business Media
ISBN: 0387848517
Category : Medical
Languages : en
Pages : 437
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Book Description
For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.
