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Author: John A. Mol
Publisher: Springer
ISBN: 9781475786422
Category : Science
Languages : en
Pages : 314
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Book Description
Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Author: John A. Mol
Publisher: Springer
ISBN: 9781475786422
Category : Science
Languages : en
Pages : 314
Get Book Here
Book Description
Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Author: Bert W. O'Malley
Publisher:
ISBN:
Category : Cyclic nucleotides
Languages : en
Pages : 488
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Book Description
Hormone assays; Hormone receptors; Evaluation of biological effects of hormones; Purification and synthesis of hormones.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309171318
Category : Medical
Languages : en
Pages : 311
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Book Description
Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.
Author: Maria del Mar Vivanco
Publisher: Humana
ISBN: 9781493925186
Category : Science
Languages : en
Pages : 0
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Book Description
The identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.
Author: C.V. Clevenger
Publisher: IOS Press
ISBN: 9781586034474
Category : Medical
Languages : en
Pages : 96
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Book Description
This publication focuses on the subject of signal transduction and its role in the pathogenesis and progression of human breast cancer. Within the past 10 years, the explosion in our knowledge of these processes has significantly altered our understanding of breast cancer, and resulted in the first receptor-based therapies. This volume examines a variety of relevant signalling pathways in mammary epithelium and explores their mechanisms and functional contribution to the evolution of this disease. The articles herein explore receptor-based signalling that occurs both at the cell surface and within the nucleus that controls the gene expression required for the breast cancer phenotype. Of course, any good series of reviews should open up more questions than they answer, and the current collection of review provides no exception. It is our desire that the discussions engendered by the reviews herein stimulate additional research on these topics. Clearly, further mechanistic understanding of these underpinnings of breast neoplasia has been and will be the wellspring for novel therapies of this disease.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 111900084X
Category : Medical
Languages : en
Pages : 2004
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Muin S. A. Tuffaha
Publisher: John Wiley & Sons
ISBN: 9783527318810
Category : Medical
Languages : en
Pages : 312
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Book Description
Carefully designed as an easy and quick reference, this desktop manual is for working pathologists who need to determine the particular type of cancer they are dealing with in a patient. To this end, the book contains many large tables of information to allow a fast analysis of results, providing all the relevant information to diagnose the full range of different tumors in humans. Must-have content for all cancer pathologists.
Author: Jay R. Harris
Publisher: Lippincott Williams & Wilkins
ISBN: 1451148704
Category : Medical
Languages : en
Pages : 3432
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Book Description
Completely revised and updated, and now in full color throughout, the Fourth Edition of this definitive reference is a must for all clinicians who treat breast diseases. Leading experts summarize the current knowledge of breast diseases, including their clinical features, management, underlying biologies, and epidemiologies. In addition to complete coverage of malignant breast diseases, benign diseases are discussed in relation to subsequent breast cancer development. The book reviews all major clinical trials and summarizes the information they provide on early detection and management of breast cancer. Close attention is also given to the increasing importance of molecular biology and genetics in this field. This edition features more than thirty new contributors, fourteen new or completely rewritten chapters, and more clinically oriented chapters. A companion Website will offer the fully searchable text and an image bank. Also included with this edition is the Anatomical Chart Company's Breast Anatomy and Disorders Pocket Guide. This durable, portable folding pocket guide provides a visual and textual overview of breast anatomy, disorders, and breast self-examination. With a write-on, wipe-off laminated surface, this guide is perfect for the on-the-go practitioner to show patients, caregivers, and families.
Author: Ben Davidson
Publisher: Springer
ISBN: 3319764780
Category : Medical
Languages : en
Pages : 303
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Book Description
This revised and updated second edition contains multiple microscopic illustrations of all diagnostic entities and ancillary techniques, providing a comprehensive, authoritative guide to all aspects of serous effusions. It now includes the many new antibodies which have been tested since the previous edition, as well as a discussion on next-generation sequencing and molecularly targeted therapy. Section one covers diagnosis for benign and malignant effusions while section two discusses biology, therapy, and prognosis highlighting clinical approaches that may be of value. Serous Effusions provides an indispensable guide to all aspects of current practice for cytopathologists, cytotechnicians, pathologists, clinicians and researchers in training and practice.
Author: James D. Adams
Publisher: Royal Society of Chemistry
ISBN: 1849731608
Category : Medical
Languages : en
Pages : 319
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Book Description
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
