Author: Joshua Denis Schnell
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The unicellular eukaryote Saccharomyces cerevisiae can be used as a model system to study ubiquitin-dependent uptake of a signaling receptor. A screen for mutants defective in receptor uptake identified a number of possible candidates genes in this pathway. One of the isolated mutants was characterized further, revealing a novel role for a conserved kinase cascade in regulating endocytosis.
Author: Susan Chun-I. Shih
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The finding that monoubiquitin serves as an autonomous internalization and the identification of ubiquitin-binding proteins that function in endocytosis validates the importance of the role of ubiquitin in endocytosis. One hypothesis how ubiquitin signals internalization is that specific endocytic proteins recognize and recruit the ubiquitinated cargo to the endocytic pathway. Because the ubiquitin binding domains of epsins and Vps27 are required for ubiquitinated cargo sorting at the internalization and multivesicular sorting step, they may be the potential adaptor proteins that recognize ubiquitinated cargo at distinct cellular compartments.
Author: Nathaniel Scott Russell
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Stephen Joseph Palmieri
Publisher:
ISBN:
Category : Saccharomyces cerevisiae
Languages : en
Pages : 360
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Book Description
Author: John R Pringle
Publisher:
ISBN: 9788796936499
Category :
Languages : en
Pages : 1131
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Book Description
Author: Milton J. Schlesinger
Publisher: Cold Spring Harbor Laboratory Press
ISBN:
Category : Science
Languages : en
Pages : 218
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Book Description
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 768
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Book Description
Author:
Publisher: Academic Press
ISBN: 9780128186671
Category : Science
Languages : en
Pages : 0
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Book Description
Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more.
Author: J. Robin Harris
Publisher: Springer Nature
ISBN: 3030589714
Category : Science
Languages : en
Pages : 580
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Book Description
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Robin Leatherbarrow
Publisher: Royal Society of Chemistry
ISBN: 1847550258
Category : Science
Languages : en
Pages : 292
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Book Description
In the post-genomic world, advances in the comprehension of cell behaviour will depend upon scientists deciphering the molecular basis of interactions between proteins and membranes. Bringing together contributions from chemists, biologists and physicists, Biophysical Chemistry: Membranes and Proteins demonstrates how multidisciplinary teams can gain insights into understanding complex biological systems. This book reflects both the scope and the interdisciplinary nature of the field, with topics including: modelling of biological systems; membrane structure and interactions; probing biomolecules; and channels and receptors. Full of stimulating articles and opinions, readers from academia and industry will welcome the wide range of coverage and the state-of-the-art science.
