Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology - An Overview PDF Download
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Author: Shiva Prasad Potta
Publisher:
ISBN:
Category : Science
Languages : en
Pages :
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Book Description
Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology - An overview.
Author: Shiva Prasad Potta
Publisher:
ISBN:
Category : Science
Languages : en
Pages :
Get Book Here
Book Description
Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology - An overview.
Author: Saura C. Sahu
Publisher: John Wiley & Sons
ISBN: 1119135435
Category : Science
Languages : en
Pages : 1010
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Book Description
A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
Author: G. Sitta Sittampalam
Publisher:
ISBN: 9781849731737
Category : Medical
Languages : en
Pages : 400
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Book Description
This book will focus on the principle non-therapeutic ('superior cell tools') applications of stem cell technology, but will also include the emerging field of soluble, regenerative medicines. The scope will be a broad, contemporary review of the current state of the art for stem cell utilities in the biopharmaceutical research sector, with emphasis on technology strengths, challenges to resolve and prospects for future development. It will provide cutting edge opinion from academic and industrial leaders in the sector. The book's objectives include an overview of the fundamental science and technology components that underpin the utilities, an in depth review of the strength of the technology using a representative biopharmaceutical pipeline and case studies covering key therapeutic/development areas (oncology, cardio-vascular, neuroscience, safety pharmacology) and prediction of advanced applications (disease modelling, regenerative medicine). The book goes beyond the renowned applications and via the inclusion of hot topics such as reprogramming and modelling of tissue function in vitro will conveniently set the scene for further consideration as these fields continue to evolve. The editors collectively have nearly 35 years experience in the biopharmaceutical sector, many spent on direct utilization of stem cells and current affiliations are balanced by this in deployment to cover both academic and industrial perspectives. As the industry expands, investments increase and new international entrants and applications into the sector appear, a book reviewing contemporary and anticipating future stem cell utilities will be in major demand as no single review article can adequately cover the whole sector.
Author: Theodore P. Rasmussen
Publisher: John Wiley & Sons
ISBN: 1119283221
Category : Science
Languages : en
Pages : 388
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Book Description
This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives
Author: Khawaja Husnain Haider
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110493551
Category : Science
Languages : en
Pages : 269
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Book Description
Stem cell based therapy is a 21st century approach of therapeutic intervention which epitomizes a shift from conventional symptomatic treatment strategy to addressing the root cause of the disease process. This is especially a hope for the patients suffering from diseases such as Alzheimer, diabetes, myocardial infarction and other diseases which have always been considered as incurable. Moreover, stem cells provide excellent in vitro disease models for drug development. This book is a compilation of the bench experience of experts from various research labs involved in the cutting edge area of research, describing the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development.
Author: James L Sherley
Publisher: Royal Society of Chemistry
ISBN: 1782626786
Category : Medical
Languages : en
Pages : 316
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Book Description
Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Author: Deepak A. Lamba
Publisher: CRC Press
ISBN: 1315402173
Category : Medical
Languages : en
Pages : 279
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Book Description
One of the biggest challenges faced in medical research had been to create accurate and relevant models of human disease. A number of good animal models have been developed to understand the pathophysiology. However, not all of them reflect the human disorder, a classic case being Usher’s syndrome where the mutant mice do not have the same visual and auditory defects that patients face. There are others which have been even more difficult to model due to the multi-factorial nature of the condition and due to lack of discovery of a single causative gene such as age-related macular degeneration or Alzheimer’s syndrome. Thus a more relevant and accurate system will allow us to make better predictions on relevant therapeutic approaches. The discovery of human pluripotent stem cells in 1998 followed by the technological advances to reprogram somatic cells to pluripotent-stem cell-like cells in 2006 has completely revolutionized the way we can now think about modelling human development and disease. This now coupled with genome editing technologies such as TALENS and CRISPRs have now set us up to develop in vitro models both 2D as well as 3D organoids, which can more precisely reflect the disease in the patients. These combinatorial technologies are already providing us with better tools and therapeutics in drug discovery or gene therapy. This book summarizes both the technological advances in the field of generation of patient specific lines as well as various gene editing approaches followed by its applicability in various systems. The book will serve as a reference for the current state of the field as it: -Provides a comprehensive overview of the status of the field of patients derived induced pluripotent stem cells. -Describes the use of cardiac cells as a main featured component within the book. -Examines drug toxicity analysis as a working example throughout the book.
Author:
Publisher: Springer
ISBN: 9781617792021
Category :
Languages : en
Pages : 490
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Book Description
Author: Arlene Chiu
Publisher: Springer Science & Business Media
ISBN:
Category : Science
Languages : en
Pages : 488
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Book Description
A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
Author: Uma Lakshmipathy
Publisher: Humana Press
ISBN: 9781627033497
Category : Science
Languages : en
Pages : 292
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Book Description
Human pluripotent stem cells such as human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) with their unique developmental plasticity hold immense potential as cellular models for drug discovery and in regenerative medicine as a source for cell replacement. While hESC are derived from a developing embryo, iPSC are generated with forced expression of key transcription factors to convert adult somatic cells to ESC-like cells, a process termed reprogramming. Using iPSC overcomes ethical issues concerning the use of developing embryos and it can be generated from patient-specific or disease-specific cells for downstream applications. Pluripotent Stem Cells: Methods and Protocols highlights the best methods and systems for the entire work flow. Divided into four convenient sections, topics include a focus on producing iPSC from diverse somatic sources, media systems for expanding ESC and iPSC with detailed protocols for directed differentiation into specific lineages, commonly used cellular and molecular characterization methods , and the potential application of labeled stem cells with specific methods for cloning, gene delivery and cell engineering. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Pluripotent Stem Cells: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential cellular feature.
