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Author: Kapil Mehta
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318004693
Category : Medical
Languages : en
Pages : 294
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Book Description
In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pathways leading to cell growth, apoptosis, and differentiation, the enzymatic functions of CD38 may contribute to an array of immunoregulatory functions. Ligation of CD38 with agonistic antibodies induces diverse effects in hematopoietic cells which range from growth stimulation to induction and prevention of apoptosis, induction of cytokines, and activation of certain kinases. Based on these observations a ligand for CD38 was recently identified and characterized. The natural ligand is capable of transducing signals similar to the agonistic antibody, following its interaction with cell surface CD38. Recent reports have suggested an association of CD38 in diverse human pathologies such as HIV, chronic B lymphocytic leukemia, myeloma, lymphoma, diabetes, and retinoic acid syndrome. This book offers the first single source on CD38 antigen and related molecules for new and experienced investigators. It will allow them to pose new and right questions in an attempt to elucidate the biological relevance and significance of these molecules in cancer, immunology, pharmacology and biochemistry.
Author: Kapil Mehta
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318004693
Category : Medical
Languages : en
Pages : 294
Get Book Here
Book Description
In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pathways leading to cell growth, apoptosis, and differentiation, the enzymatic functions of CD38 may contribute to an array of immunoregulatory functions. Ligation of CD38 with agonistic antibodies induces diverse effects in hematopoietic cells which range from growth stimulation to induction and prevention of apoptosis, induction of cytokines, and activation of certain kinases. Based on these observations a ligand for CD38 was recently identified and characterized. The natural ligand is capable of transducing signals similar to the agonistic antibody, following its interaction with cell surface CD38. Recent reports have suggested an association of CD38 in diverse human pathologies such as HIV, chronic B lymphocytic leukemia, myeloma, lymphoma, diabetes, and retinoic acid syndrome. This book offers the first single source on CD38 antigen and related molecules for new and experienced investigators. It will allow them to pose new and right questions in an attempt to elucidate the biological relevance and significance of these molecules in cancer, immunology, pharmacology and biochemistry.
Author: Hon Cheung Lee
Publisher: Springer Science & Business Media
ISBN: 9781402072819
Category : Medical
Languages : en
Pages : 488
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Book Description
In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.
Author: Sangdun Choi
Publisher: Springer
ISBN: 9781441904607
Category : Medical
Languages : en
Pages : 0
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Book Description
Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.
Author: János Fischer
Publisher: John Wiley & Sons
ISBN: 3527343032
Category : Medical
Languages : en
Pages : 472
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Book Description
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
Author: Kapil Mehta
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805569238
Category : Medical
Languages : en
Pages : 294
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Book Description
In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pathways leading to cell growth, apoptosis, and differentiation, the enzymatic functions of CD38 may contribute to an array of immunoregulatory functions. Ligation of CD38 with agonistic antibodies induces diverse effects in hematopoietic cells which range from growth stimulation to induction and prevention of apoptosis, induction of cytokines, and activation of certain kinases. Based on these observations a ligand for CD38 was recently identified and characterized. The natural ligand is capable of transducing signals similar to the agonistic antibody, following its interaction with cell surface CD38. Recent reports have suggested an association of CD38 in diverse human pathologies such as HIV, chronic B lymphocytic leukemia, myeloma, lymphoma, diabetes, and retinoic acid syndrome. This book offers the first single source on CD38 antigen and related molecules for new and experienced investigators. It will allow them to pose new and right questions in an attempt to elucidate the biological relevance and significance of these molecules in cancer, immunology, pharmacology and biochemistry.
Author: Tasuku Honjo
Publisher: Elsevier
ISBN: 0123984904
Category : Medical
Languages : en
Pages : 587
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Book Description
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. - Covers signaling mechanisms regulating B cell differentiation - Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab - Contains studies on B cell tumors from various stages of B lymphocytes - Offers an integrated view of all aspects of B cells to produce a normal immune response
Author: Friedrich Haag
Publisher: Springer Science & Business Media
ISBN: 9780306455100
Category : Medical
Languages : en
Pages : 0
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Book Description
Documents the first conference on the topic, called in response to opportunities opened by the molecular characterization of the first mammalian mono(ADP-ribosyl)transferase enzyme from rabbit skeletal muscles, and the subsequent realization that one had already been to hand in a well-studied surfac
Author: Runjan Chetty
Publisher: Cambridge University Press
ISBN: 1316592065
Category : Medical
Languages : en
Pages : 525
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Book Description
Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.
Author: Anna Porwit
Publisher: Cambridge University Press
ISBN: 1108548830
Category : Medical
Languages : en
Pages : 248
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Book Description
Master implementation of the techniques of flow cytometry in diagnosing complex haematological diseases and malignancies in patients, worldwide. Featuring World Health Organization recommendations on pre-analytical steps, instrument settings and panel construction, this invaluable manual offers invaluable support for those researching, practising and analyzing the cause of hematological malignancies. Authored by leading experts, this book puts flow-cytometry into everyday context. With a focus on multicolour panels, the manual provides readers an experienced understanding of effective, implementation techniques. Practitioners of all levels are offered a background in a variety of diseases presented alongside the most current methodology. Wide-ranging and comprehensive; detailed images of healthy blood, bone marrow and lymph-nodes are illustrated throughout, allowing for effective diagnosis. Through engaging with differential diagnoses, the manual offers an understanding of similar symptoms and mimicking malignancies, avoiding inaccurate results. Featuring in-depth descriptions of chronic diseases; users can reach accurate diagnosis, first time.
Author: Roland W. Herzog
Publisher: World Scientific
ISBN: 9814280917
Category : Medical
Languages : en
Pages : 415
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Book Description
1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clinical studies in gene therapy / Caroline Le Guiner [und weitere] -- 11. Gene therapy for central nervous system disorders / Deborah Young and Patricia A. Lawlor -- 12. Gene therapy of hemoglobinopathies / Angela E. Rivers and Arun Srivastava -- 13. Gene therapy for primary immunodeficiencies / Aisha Sauer, Barbara Cassani and Alessandro Aiuti -- 14. Gene therapy for hemophilia / David Markusic, Babak Moghimi and Roland Herzog -- 15. Gene therapy for obesity and diabetes / Sergei Zolotukhin and Clive H. Wasserfall -- 16. Gene therapy for Duchenne muscular dystrophy / Takashi Okada and Shin'ichi Takeda -- 17. Cancer gene therapy / Kirsten A.K. Weigel-Van Aken -- 18. Gene therapy for autoimmune disorders / Daniel F. Gaddy, Melanie A. Ruffner and Paul D. Robbins -- 19. Gene therapy for inherited metabolic storage diseases / Cathryn Mah -- 20. Retinal diseases / Shannon E. Boye, Sanford L. Boye and William W. Hauswirth -- 21. A brief guide to gene therapy treatments for pulmonary diseases / Ashley T. Martino, Christian Mueller and Terence R. Flotte -- 22. Cardiovascular disease / Darin J. Falk, Cathryn S. Mah and Barry J. Byrne
