Author: JG WILSON (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
VOL 1 GENERAL PRINCIPLES AND ETIOLOGY. VOL 2 MECHANISMS AND.

Author: JG WILSON (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
VOL 1 GENERAL PRINCIPLES AND ETIOLOGY. VOL 2 MECHANISMS AND PATHOGENESIS. VOL 3 COMPARATIVE, MATERNAL, AND EPIDEMIOLOGIC ASPECTS. VOL 4 RESEARCH PROCEDURES AND DATA ANALYSIS.

Author: James Graves Wilson
Publisher:
ISBN:
Category :
Languages : en
Pages : 491

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Author: James Wilson
Publisher: Springer
ISBN: 9780306362439
Category : Science
Languages : en
Pages : 360

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Book Description
Modification of embryonic development by genetic differences in the mother is a well-regcognized phemomenon, but little is known about the genet ics of these maternal traits or the mechanisms by which they act. To illustrate the genetic approach to the problem, examples are given of how differences in embryonic response to a teratogen can be partitioned into those resulting from differences in embryonic genotype (including the possible role of X-linked genes in producing reciprocal cross differences), maternal genotype, and cytoplasmically transmitted factors. The advantages and limitations of analysis by appropriate crosses, in utero treatments, embryo transfers, and in vitro experiments are illustrated. The numerous inbred strains of the mouse, with well-documented physiology, the recently developed recombinant inbred strains, and the existence of easily identified biochemical marker genes offer at tractive opportunities, so far largely unexploited, for causal analysis of mater nal effects on teratological responses. VII. ADDENDUM Since this chapter was written, several relevant papers have appeared. The strain difference between AI] and C57BU6] mice in frequency of cleft-palate response to cortisone was fitted to a model of normally distributed log tolerance (Biddle and Fraser, 1976). Genetic differences, both in maternal uterine environment and embryonic response, can be represented in terms of their effect on the median effective dose required for the cleft-palate re sponse. The maternal effect of AI] dams relative to C57BU6] dams caused a two-fold reduction in embryonic tolerance to cortisone-induced cleft palate.

Author: James Wilson
Publisher: Springer Science & Business Media
ISBN: 1461589363
Category : Science
Languages : en
Pages : 336

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Book Description
Modification of embryonic development by genetic differences in the mother is a well-regcognized phemomenon, but little is known about the genet ics of these maternal traits or the mechanisms by which they act. To illustrate the genetic approach to the problem, examples are given of how differences in embryonic response to a teratogen can be partitioned into those resulting from differences in embryonic genotype (including the possible role of X-linked genes in producing reciprocal cross differences), maternal genotype, and cytoplasmically transmitted factors. The advantages and limitations of analysis by appropriate crosses, in utero treatments, embryo transfers, and in vitro experiments are illustrated. The numerous inbred strains of the mouse, with well-documented physiology, the recently developed recombinant inbred strains, and the existence of easily identified biochemical marker genes offer at tractive opportunities, so far largely unexploited, for causal analysis of mater nal effects on teratological responses. VII. ADDENDUM Since this chapter was written, several relevant papers have appeared. The strain difference between AI] and C57BU6] mice in frequency of cleft-palate response to cortisone was fitted to a model of normally distributed log tolerance (Biddle and Fraser, 1976). Genetic differences, both in maternal uterine environment and embryonic response, can be represented in terms of their effect on the median effective dose required for the cleft-palate re sponse. The maternal effect of AI] dams relative to C57BU6] dams caused a two-fold reduction in embryonic tolerance to cortisone-induced cleft palate.

Author: James Graves Wilson
Publisher:
ISBN:
Category : Abnormalities, Human
Languages : en
Pages :

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Book Description

Author: E.P. Riley
Publisher: Springer Science & Business Media
ISBN: 1461321891
Category : Psychology
Languages : en
Pages : 829

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Book Description
This book was developed in response to a need in behavioral teratology for a comprehen sive set of reviews of the field's many topics brought together in a single source. This volume represents the first effort to synthesize and integrate research in the field since 1969 when Justin Joffe wrote Prenatal Determinants of Behaviour. Joffe's book became a standard reference for many years, particularly for the experimental design of animal investigations. It has become increasingly evident, however, that some aspects of design once considered inviolate have changed and become part of a more flexible approach. In current research the emphasis is on a set of prioritized, but focused, experimental ques tions rather than on designs which factor all possible variables into every experiment. Also, new design considerations have arisen over the last 15 years, not appreciated when Joffe wrote. Moreover, the sheer volume of new experimental evidence generated since 1969 has increased the content of the field several fold. These considerations made a new review and critical appraisal of the field compelling. The book is divided into four major sections. Part I contains four chapters. These chapters provide discussions of the general principles of behavioral teratogenesis, and information on the historical, governmental, and methodological contexts in which the field operates. The purpose of these chapters is to provide the framework within which the review chapters in the remainder of the book may best be understood.

Author: Michele Kiely
Publisher: CRC Press
ISBN: 1000006328
Category : Medical
Languages : en
Pages : 556

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Book Description
First Published in 1990, Reproductive and Perinatal Epidemiology reviews topics that are central to reproductive and perinatal epidemiology, as well as the methodological issues surrounding research in maternal and child health. Important topics covered include prenatal care, Sudden Infant Death Syndrome (SIDS), epidemiology of neonatal brain hemorrhage, early pregnancy, methodological issues in drug epidemiology, environmental exposures and reproduction, and occupational exposures and reproduction. This book is essential reading for clinicians, researchers, obstetricians, pediatricians, and graduate students in public health.

Author: James Wilson
Publisher: Springer Science & Business Media
ISBN: 1461589398
Category : Science
Languages : en
Pages : 459

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Book Description

Author: H.O. Lancaster
Publisher: Springer Science & Business Media
ISBN: 1461210038
Category : Social Science
Languages : en
Pages : 618

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Book Description
Destined to become a classic epidemiological study, EXPECTA- TIONS OF LIFE surveys world mortality, describing and ex- plaining the declines of mortality which have become especi- ally evident in this century.