Handbook of Mitochondrial Dysfunction

Handbook of Mitochondrial Dysfunction PDF Author: Shamim I. Ahmad
Publisher: CRC Press
ISBN: 0429811772
Category : Medical
Languages : en
Pages : 503

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Book Description
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Handbook of Mitochondrial Dysfunction

Handbook of Mitochondrial Dysfunction PDF Author: Shamim I. Ahmad
Publisher: CRC Press
ISBN: 0429811772
Category : Medical
Languages : en
Pages : 503

Get Book Here

Book Description
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Handbook of Mitochondrial Dysfunction

Handbook of Mitochondrial Dysfunction PDF Author: Shamim I. Ahmad
Publisher: CRC Press
ISBN: 0429811772
Category : Medical
Languages : en
Pages : 503

Get Book Here

Book Description
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Handbook of Neurodegenerative Disorders

Handbook of Neurodegenerative Disorders PDF Author: Musthafa M. Essa
Publisher: Springer Nature
ISBN: 9819975573
Category :
Languages : en
Pages : 1026

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Book Description


Handbook of Ataxia Disorders

Handbook of Ataxia Disorders PDF Author: Thomas Klockgether
Publisher: CRC Press
ISBN: 9781420002065
Category : Medical
Languages : en
Pages : 716

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Book Description
This timely reference presents, for the first time, new findings in molecular genetics that are applicable to the epidemiology, pathogenesis, neuropathology, clinical features, and management of ataxia-bridging the gap between scientific and clinical practice. Organized by the distinctive ataxia disorders, their pathogenesis, and management-facilitating quick and efficient diagnoses! Providing complementary sections on the anatomy of the spinocerebellar system, its normal function, and a history of ataxia research and management, the Handbook of Ataxia Disorders clarifies the impact of identifying the molecular causes of ataxia offers in-depth analysis of dominant and recessive and nonhereditary ataxia disorders explores the vital connection between the genotypes and phenotypes of various degenerative ataxia disorders and more! Written by more than 60 international experts and supplemented with over 2600 literature references, photographs, micrographs, drawings, and tables, the Handbook of Ataxia Disorders is an essential and useful reference for clinical neurologists and neuropathologists, neuropediatricians, geneticists, physiatrists, and medical school students in these disciplines.

Handbook of Neurotoxicology

Handbook of Neurotoxicology PDF Author: Edward J. Massaro
Publisher: Springer Science & Business Media
ISBN: 1592591329
Category : Medical
Languages : en
Pages : 658

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Book Description
Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Massachusetts General Hospital Handbook of General Hospital Psychiatry E-Book

Massachusetts General Hospital Handbook of General Hospital Psychiatry E-Book PDF Author: Theodore A. Stern
Publisher: Elsevier Health Sciences
ISBN: 0323496431
Category : Medical
Languages : en
Pages : 791

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Book Description
For generations of practitioners, the Massachusetts General Hospital Handbook of General Hospital Psychiatry has been and is the "gold standard" guide to consultation-liaison psychiatry and psychosomatic medicine. The fully updated 7th Edition, by Drs. Theodore A. Stern, Oliver Freudenreich, Felicia A. Smith, Gregory L. Fricchione, and Jerrold F. Rosenbaum, provides an authoritative, easy-to-understand review of the diagnosis, evaluation, and treatment of psychiatric problems experienced by adults and children with medical and surgical conditions. Covers the psychological impact of chronic medical problems and life-threatening diseases, somatic symptom disorders, organ donors and recipients, pain, substance abuse, and polypharmacy, including a thorough review of drug actions and interactions, metabolism, and elimination. - Features DSM-5 updates throughout, as well as case studies in every chapter. - Contains practical tips on how to implement the most current and effective pharmacological therapies as well as cognitive-behavioral approaches. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

The Harriet Lane Handbook E-Book

The Harriet Lane Handbook E-Book PDF Author: The Johns Hopkins Hospital
Publisher: Elsevier Health Sciences
ISBN: 0323674097
Category : Medical
Languages : en
Pages : 1409

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Book Description
Every three years, The Harriet Lane Handbook is carefully updated by residents, edited by chief residents, and reviewed by expert faculty at The Johns Hopkins Hospital. Easy to use, concise, and complete, this essential manual keeps you current with new guidelines, practice parameters, pharmacology, and more. The 22nd Edition of this portable reference continues to be the #1 source of pediatric point-of-care clinical information for pediatric residents, students, nurses, and all healthcare professionals who treat young patients. - Trusted for more than 65 years for fast, accurate information on pediatric diagnosis and treatment. - Updated and expanded content includes an all-new chapter on Psychiatry, plus reorganized information on Emergency and Critical Care Management, as well as Traumatic Injuries. - The popular Pediatric Drug Formulary, updated by Carlton K. K. Lee, PharmD, MPH, provides the latest in pharmacologic treatment of pediatric patients. - Outline format ensures you'll find information quickly and easily, even in the most demanding circumstances.

Handbook of Medical Neuropsychology

Handbook of Medical Neuropsychology PDF Author: Carol L. Armstrong
Publisher: Springer Nature
ISBN: 3030148955
Category : Psychology
Languages : en
Pages : 815

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Book Description
This ambitious and important second edition of the Handbook of Medical Neuropsychology takes an in-depth approach to the medical conditions and methods of neurorehabilitation. Comprehensive in scope and highly detailed in its coverage, the second edition, like the first, characterizes the effects of disease and the impact of interventions in the current state of advanced medicine at a level appropriate both for researchers and for clinicians. Featuring the most up-to-date information and quantitative research on cognitive neuroscience of autism, HIV/AIDS, cancer, head injury, respiratory diseases, endocrine diseases, early birth injury, dementia, and other disorders, the book handles theory, historical background, practical considerations, and controversial areas with evidence based disease indicators, clinical expertise, and real-world insight. It seeks to critique diagnostic and assessment tools specific to disorders. The new chapters in this inclusive second edition reflect the changes in prominent problems found in the clinic and provide worthy insights for research investigation in their review of: Substance use disorders. Nutrition in neurocognition and mental health. Hypothyroidism and Hashimoto’s thyroiditis. Traumatic brain injury in very early childhood. Cognitive functioning in asthma. The role of mindfulness in neurorehabilitation. The Handbook of Medical Neuropsychology, 2nd Edition continues to be an essential resource for the neuropsychology clinician, researcher, practitioner or graduate student. It will be stimulating and relevant reading for years to come.

Handbook of Veterinary Neurology - E-Book

Handbook of Veterinary Neurology - E-Book PDF Author: Michael D. Lorenz
Publisher: Elsevier Health Sciences
ISBN: 1437706525
Category : Medical
Languages : en
Pages : 562

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Book Description
Handbook of Veterinary Neurology provides quick access to vital information on neurologic conditions in a wide range of species, including canine, feline, bovine, caprine, equine, ovine, and porcine. A problem-oriented approach makes it easy to diagnose and treat neurologic problems in small and large animals. The coverage of disorders by problem, not by established disease diagnosis, emulates how animals present to the veterinary hospital and simplifies the formulation of a correct diagnosis. Within each chapter, discussions of neurologic disease include a review of the localization criteria and the diseases that can cause that problem, plus treatment and surgical techniques. Lead author Michael D. Lorenz brings decades of experience to neurologic assessment, using a diagnostic approach that requires minimal knowledge of neuroanatomy. - A problem-based approach is organized by presenting sign rather than by condition, guiding you to logical conclusions regarding diagnosis and treatment. - Algorithms diagram the logic necessary to localize lesions and to formulate diagnostic plans. - Coverage of current diagnostic techniques includes the use of diagnostic tools, such as radiology, spinal fluid analysis, electrodiagnosis, and MR imaging. - Case histories in each chapter present a problem and the results of the neurologic examination, then ask you to solve the problem by localizing the lesion, listing probable causes, and making a diagnostic plan. Answers are provided at the back of the book. - A consistent format for each case history includes signalment, history, physical examination findings, and neurologic examination. - A comprehensive appendix describes species and breeds that have a congenital predisposition for particular neurologic diseases. - Extensive references make it easy to pursue in-depth research of more advanced topics. - A companion website includes 20 narrated video clips with accompanying PowerPoint slides that correlate to the case histories in the book, covering neurologic assessment and clinical problems such as paresis of one limb, tetraparesis, stupor, seizures, ataxia of the head and limbs, and cranial nerve disorders. - Two new co-authors, Jean Coates and Marc Kent, board-certified in neurology, enhance the credibility of this edition. - A full-color design and numerous illustrations include enhanced images of neuroanatomy and pathology.

Oxford Handbook of Neurology

Oxford Handbook of Neurology PDF Author: Hadi Manji
Publisher: OUP Oxford
ISBN: 019103956X
Category : Medical
Languages : en
Pages : 579

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Book Description
Fully updated for this second edition, the Oxford Handbook of Neurology is the definitive guide for all those working in neurology and neurosurgery. This practical and concise quick-reference resource includes a wealth of information and invaluable clinical guidance to ensure all readers stay up-to-date in this fast-moving specialty. Now including brand new chapters on neurological emergencies and neurology within other medical specialties, this handbook includes the most cutting-edge management and treatment options, drugs, and neurosurgical techniques. Covering the entire breadth of neurology with additional sections on neuroanatomy, neurosurgery, neuroradiology and neurophysiology, it includes common presentations and disorders as well as information on neurological assessment. Packed full of illustrations to ensure ease-of reference, and valuable clinical advice from experts in the field, the reader can be sure they will always have all the information they need at their fingertips.