Handbook of Depression in Alzheimer's Disease PDF Download
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Author: Gwenn S. Smith
Publisher:
ISBN: 9781614995418
Category : Alzheimer's disease
Languages : en
Pages : 0
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Book Description
Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimer's disease (AD) in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimer's disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden.This book, volume 4 of the Advances in Alzheimer's Disease book series which is published in coordination with the Journal of Alzheimer's Disease, presents papers which reflect the progress in recent years of research into depression in AD. This research has focused on several areas, including the improvement of diagnostic criteria and outcome measures for depression and depressive symptoms in AD, genetic and imaging studies to elucidate the neurobiological mechanisms, and clinical trials of antidepressants. The book is divided into sections on phenomenology, epidemiology, neuropsychology, neurobiology and neuropathology, neuroimaging, genetics, and treatment.Providing a stimulus to further research in this challenging area by engaging both basic and clinical researchers, this book will be of interest to all those whose work involves understanding and dealing with depression in those suffering from Alzheimer's disease.
Author: Gwenn S. Smith
Publisher:
ISBN: 9781614995418
Category : Alzheimer's disease
Languages : en
Pages : 0
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Book Description
Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimer's disease (AD) in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimer's disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden.This book, volume 4 of the Advances in Alzheimer's Disease book series which is published in coordination with the Journal of Alzheimer's Disease, presents papers which reflect the progress in recent years of research into depression in AD. This research has focused on several areas, including the improvement of diagnostic criteria and outcome measures for depression and depressive symptoms in AD, genetic and imaging studies to elucidate the neurobiological mechanisms, and clinical trials of antidepressants. The book is divided into sections on phenomenology, epidemiology, neuropsychology, neurobiology and neuropathology, neuroimaging, genetics, and treatment.Providing a stimulus to further research in this challenging area by engaging both basic and clinical researchers, this book will be of interest to all those whose work involves understanding and dealing with depression in those suffering from Alzheimer's disease.
Author: John Wesson Ashford
Publisher: Ios PressInc
ISBN: 9781607507925
Category : Medical
Languages : en
Pages : 808
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Book Description
Alzheimers disease is a common problem that is becoming progressively more prevalent and burdensome to the world. Through better recognition of this disease and more precise diagnosis, led by brain imaging in the appropriate clinical context, it is our
Author: R.J. Castellani
Publisher: IOS Press
ISBN: 164368065X
Category : Medical
Languages : en
Pages : 506
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Book Description
Holbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.
Author: George Perry
Publisher: IOS Press
ISBN: 9781586036195
Category : Medical
Languages : en
Pages : 478
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Book Description
"This is the book edition of the Journal of Alzheimer's Disease, Volume 9, No.3 Supplement (2006)"--T.p. verso.
Author: C.G. Kruse
Publisher: IOS Press
ISBN: 1607502186
Category : Medical
Languages : en
Pages : 144
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Book Description
100 Years after the discovery of Alzheimer’s disease, neurological diseases and psychiatric disorders represent the largest and fastest growing unmet medical market with 2 billion affected people worldwide. Life expectancy of humans continues to increase, and the world population is aging. Advanced age may lead to deterioration of cognitive functions of the brain. There seems to be consensus that on the background of aging, several factors may render humans prone to dementia. Psychiatric and neurological disorders such as schizophrenia, bipolar disorder or Parkinson’s disease may contribute to development of dementia. More people today are looking for help regarding their learning and memory capabilities. Although increasing knowledge on neuronal networks is transforming our view of the human brain and its function and we understand psychiatric and neurological diseases better today than ever before, novel therapies are needed to respond to the growing demand of patients for assistance with memory loss and learning impairment. In fact, it is expected that novel therapies aiming at the processing of amyloid, or at activation of glutamatergic or nicotinergic systems will demonstrate adequate efficacy in improving learning and memory disturbances. This publication stands as a comprehensive overview of the cellular and molecular mechanisms underlying the development of cognitive impairment. It integrates discoveries concerning dementia, such as mild cognitive impairment and Alzheimer’s disease associated dementia, vascular dementia, retardation syndromes, and psychiatric and neurological disorders related cognitive impairments. This book will be useful to physicians, biologists, and those pursuing an interest or concerned with memory impairment. 100 Years after the discovery of Alzheimer’s disease, neurological diseases and psychiatric disorders represent the largest and fastest growing unmet medical market with 2 billion affected people worldwide. Life expectancy of humans continues to increase, and the world population is aging. Advanced age may lead to deterioration of cognitive functions of the brain. There seems to be consensus that on the background of aging, several factors may render humans prone to dementia. Psychiatric and neurological disorders such as schizophrenia, bipolar disorder or Parkinson’s disease may contribute to development of dementia. More people today are looking for help regarding their learning and memory capabilities. Although increasing knowledge on neuronal networks is transforming our view of the human brain and its function and we understand psychiatric and neurological diseases better today than ever before, novel therapies are needed to respond to the growing demand of patients for assistance with memory loss and learning impairment. In fact, it is expected that novel therapies aiming at the processing of amyloid, or at activation of glutamatergic or nicotinergic systems will demonstrate adequate efficacy in improving learning and memory disturbances. This publication stands as a comprehensive overview of the cellular and molecular mechanisms underlying the development of cognitive impairment. It integrates discoveries concerning dementia, such as mild cognitive impairment and Alzheimer’s disease associated dementia, vascular dementia, retardation syndromes, and psychiatric and neurological disorders related cognitive impairments. This book will be useful to physicians, biologists, and those pursuing an interest or concerned with memory impairment.
Author: I. A. F. Stokes
Publisher: IOS Press
ISBN: 9789051994308
Category : Medical
Languages : en
Pages : 404
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Book Description
Diagnosis and Treatment of Spine Deformities in Children at Specialized Centre -- Session 5: Rationalized Design of Individualized Treatment -- Biomechanical Simulations for Planning of Scoliosis Surgery -- Clinical Assessment of AIS -- Determination of Fixation Level of Osteosynthesis System with Knowledge Base -- 3D" Brace Treatment: "3D" Immediate Effect On Thoracic. Thoracolumbar and Lumbar Scoliotic Curves -- Treatment of Thoracolumbar and Lumbar Idiopathic Scoliotic Curves with the Progressive Action Short Brace (P.A.S.B.)Analysis of Results -- 3D Correction of Trunk Deformity in Patients with Idiopathic Scoliosis Using Cheneau Brace -- Social Effects of Boston Bracing -- Appendix. Clinical Application of 3-D Evaluation of Scoliosis -- Pre-IRSSD meeting Workshops held at Sainte-Justine Hospital, Montreal, Canada, 27 June, 1998. -- Workshop 1: Biomechanical Modelling of Scoliosis: What are the Priorities? -- Workshop 2: Usefulness of Computer Assisted Measurements During Surgery: Should we Continue? -- Workshop 3: Imaging Techniques, which Way to Go: X-Ray, CT Scans, MRI, Surface Topography, Etc.? -- Workshop 4: Aetiology and pattern of spinal deformities: should we continue to study biomechanical and 3D factors? -- Author Index
Author: G.M. Pasinetti
Publisher: IOS Press
ISBN: 164368289X
Category : Medical
Languages : en
Pages : 732
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Book Description
Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. Interventions, including probiotic supplementation, fecal transfer, and supplementation with microbial metabolites, are discussed, as is the use of certain probiotics to study the effects of the gut microbiota on behavior and cognitive function, and as potential therapeutics for AD. Other topics covered include the influence of the gut and oral microbiota on immune inflammatory signals: cytokines, neuroendocrine hormones, bacterial components, neuroactive molecules, and microbial metabolites. The book is divided into four sections, each covering a research area pertinent to the gut-brain-axis and its relationship with cognitive function and AD. It will be of interest to all those whose work includes the study and understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive function and AD. The cover shows a color edited MRI image of a sagittal section of a neurological control brain of Dr. Giulio Maria Pasinetti.
Author: J.W. Langston
Publisher: IOS Press
ISBN: 1614993327
Category : Medical
Languages : en
Pages : 264
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Book Description
In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks
Author: Maura Mitrushina
Publisher: Oxford University Press
ISBN: 0195169301
Category : Reference
Languages : en
Pages : 1052
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Book Description
When Handbook of Normative Data for Neuropsychological Assessment was published in 1999, it was the first book to provide neuropsychologists with summaries and critiques of normative data for neuropsychological tests. The Second Edition, which has been revised and updated throughout, presents data for 26 commonly used neuropsychological tests, including: Trailmaking, Color Trails, Stroop Color Word Interference, Auditory Consonant Trigrams, Paced Auditory Serial Addition, Ruff 2 and 7, Digital Vigilance, Boston Naming, Verbal Fluency, Rey-Osterrieth Complex Figure, Hooper Visual Fluency, Design Fluency, Tactual Performance, Wechsler Memory Scale-Revised, Rey Auditory-Verbal learning, Hopkins Verbal learning, WHO/UCLA Auditory Verbal Learning, Benton Visual Retention, Finger Tapping, Grip Strength (Dynamometer), Grooved Pegboard, Category, and Wisconsin Card Sorting tests. In addition, California Verbal learning (CVLT and CVLT-II), CERAD ListLearning, and selective Reminding Tests, as well as the newest version of the Wechsler Memory Scale (WMS-III and WMS-IIIA), are reviewed. Locator tables throughout the book guide the reader to the sets of normative data that are best suited to each individual case, depending on the demographic characteristics of the patient, and highlight the advantages associated with using data for comparative purposes. Those using the book have the option of reading the authors' critical review of the normative data for a particular test, or simply turning to the appropriate data locator table for a quick reference to the relevant data tables in the Appendices. The Second Edition includes reviews of 15 new tests. The way the data are presented has been changed to make the book easier to use. Meta-analytic tables of predicted values for different ages (and education, where relevant) are included for nine tests that have a sufficient number of homogeneous datasets. No other reference offers such an effective framework for the critical evaluation of normative data for neuropsychological tests. Like the first edition, the new edition will be welcomed by practitioners, researchers, teachers, and graduate students as a unique and valuable contribution to the practice of neuropsychology.
Author: Mark Lyte
Publisher: Springer
ISBN: 1493908979
Category : Science
Languages : en
Pages : 440
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Book Description
The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.
