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Author: Philip Lee
Publisher: Wiley
ISBN: 9780470749104
Category : Science
Languages : en
Pages : 2560
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Book Description
If you’re working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists. Experience the scope of content offered in the Handbook of Metabolic Pathways of Xenobiotics for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds Review Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathways Compound Article: Ganoderic acid D Compound Article: Milnacipran Compound Article: Tenofovir Online Edition Coming Soon! Featuring the same great content as the five volume print set, the Handbook of Metabolic Pathways for Xenobiotics will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by The Smart Article – learn more about The Smart Article at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.
Author: Philip Lee
Publisher: Wiley
ISBN: 9780470749104
Category : Science
Languages : en
Pages : 2560
Get Book
Book Description
If you’re working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists. Experience the scope of content offered in the Handbook of Metabolic Pathways of Xenobiotics for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds Review Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathways Compound Article: Ganoderic acid D Compound Article: Milnacipran Compound Article: Tenofovir Online Edition Coming Soon! Featuring the same great content as the five volume print set, the Handbook of Metabolic Pathways for Xenobiotics will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by The Smart Article – learn more about The Smart Article at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.
Author: Pavel Anzenbacher
Publisher: John Wiley & Sons
ISBN: 3527646329
Category : Medical
Languages : en
Pages : 755
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Book Description
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Author: Christina Smolke
Publisher: CRC Press
ISBN: 1439802971
Category : Medical
Languages : en
Pages : 680
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Book Description
This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction
Author: David M. Greenberg
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 1386
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Book Description
Author: Ala F. Nassar
Publisher: John Wiley & Sons
ISBN: 1118097777
Category : Science
Languages : en
Pages : 224
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Book Description
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.
Author: Ala F. Nassar
Publisher: John Wiley & Sons
ISBN: 0470439254
Category : Medical
Languages : en
Pages : 1059
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Book Description
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Author: Costas Ioannides
Publisher: Royal Society of Chemistry
ISBN: 0854042741
Category : Medical
Languages : en
Pages : 584
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Book Description
With contributions by a team of internationally respected scientists, this book provides up-to-date information on the extensively studied cytochrome P450 enzyme in a very accessible manner.
Author: Bhakta, Jatindra Nath
Publisher: IGI Global
ISBN: 152252326X
Category : Nature
Languages : en
Pages : 624
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Book Description
The rapid progression of technology has significantly impacted population growth, urbanization, and industrialization in modern society. These developments, while positive on the surface, have created critical environmental problems in recent years. The Handbook of Research on Inventive Bioremediation Techniques is a comprehensive reference source for the latest scholarly information on optimizing bioremediation technologies and methods to control pollution and enhance sustainability and conservation initiatives for the environment. Highlighting pivotal research perspectives on topics such as biodegradation, microbial tools, and green technology, this publication is ideally designed for academics, professionals, graduate students, and practitioners interested in emerging techniques for environmental decontamination.
Author:
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Joseph I. Boullata
Publisher: Springer Science & Business Media
ISBN: 160327362X
Category : Science
Languages : en
Pages : 824
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Book Description
Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.
