Good News - Bad News: The Two Faces of Immune Privilege PDF Download
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Author: Rachel R. Caspi
Publisher: Frontiers Media SA
ISBN: 2889193314
Category : Immunologic diseases. Allergy
Languages : en
Pages : 110
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Book Description
Immune privilege was once thought to be the property of a few select sites that include the eye, brain, testis, pregnant uterus and (of all things) the hamster cheek pouch, and was believed to be mainly based on sequestration behind blood-tissue barriers. This view has changed. Immune privilege is now considered to constitute a more general phenomenon through which tissues are able to actively direct and control immune responses taking place in their “territory” to preserve their structural and functional integrity in the face of inflammatory processes. These positive aspects of immune privilege can be hijacked by tumors to their survival advantage and to the detriment of the host. This Research Topic dissects the beneficial and deleterious consequences of immune privilege in terms of the cellular and molecular mechanisms that various tissues and tumors use, each in its own fashion, to regulate immune processes that affect them, at the local and the systemic level.
Author: Rachel R. Caspi
Publisher: Frontiers Media SA
ISBN: 2889193314
Category : Immunologic diseases. Allergy
Languages : en
Pages : 110
Get Book Here
Book Description
Immune privilege was once thought to be the property of a few select sites that include the eye, brain, testis, pregnant uterus and (of all things) the hamster cheek pouch, and was believed to be mainly based on sequestration behind blood-tissue barriers. This view has changed. Immune privilege is now considered to constitute a more general phenomenon through which tissues are able to actively direct and control immune responses taking place in their “territory” to preserve their structural and functional integrity in the face of inflammatory processes. These positive aspects of immune privilege can be hijacked by tumors to their survival advantage and to the detriment of the host. This Research Topic dissects the beneficial and deleterious consequences of immune privilege in terms of the cellular and molecular mechanisms that various tissues and tumors use, each in its own fashion, to regulate immune processes that affect them, at the local and the systemic level.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309452961
Category : Medical
Languages : en
Pages : 583
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Book Description
In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.
Author: Ta-Nehisi Coates
Publisher: One World
ISBN: 0679645985
Category : Biography & Autobiography
Languages : en
Pages : 163
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Book Description
#1 NEW YORK TIMES BESTSELLER • NATIONAL BOOK AWARD WINNER • NAMED ONE OF TIME’S TEN BEST NONFICTION BOOKS OF THE DECADE • PULITZER PRIZE FINALIST • NATIONAL BOOK CRITICS CIRCLE AWARD FINALIST • ONE OF OPRAH’S “BOOKS THAT HELP ME THROUGH” • NOW AN HBO ORIGINAL SPECIAL EVENT Hailed by Toni Morrison as “required reading,” a bold and personal literary exploration of America’s racial history by “the most important essayist in a generation and a writer who changed the national political conversation about race” (Rolling Stone) NAMED ONE OF THE MOST INFLUENTIAL BOOKS OF THE DECADE BY CNN • NAMED ONE OF PASTE’S BEST MEMOIRS OF THE DECADE • NAMED ONE OF THE TEN BEST BOOKS OF THE YEAR BY The New York Times Book Review • O: The Oprah Magazine • The Washington Post • People • Entertainment Weekly • Vogue • Los Angeles Times • San Francisco Chronicle • Chicago Tribune • New York • Newsday • Library Journal • Publishers Weekly In a profound work that pivots from the biggest questions about American history and ideals to the most intimate concerns of a father for his son, Ta-Nehisi Coates offers a powerful new framework for understanding our nation’s history and current crisis. Americans have built an empire on the idea of “race,” a falsehood that damages us all but falls most heavily on the bodies of black women and men—bodies exploited through slavery and segregation, and, today, threatened, locked up, and murdered out of all proportion. What is it like to inhabit a black body and find a way to live within it? And how can we all honestly reckon with this fraught history and free ourselves from its burden? Between the World and Me is Ta-Nehisi Coates’s attempt to answer these questions in a letter to his adolescent son. Coates shares with his son—and readers—the story of his awakening to the truth about his place in the world through a series of revelatory experiences, from Howard University to Civil War battlefields, from the South Side of Chicago to Paris, from his childhood home to the living rooms of mothers whose children’s lives were taken as American plunder. Beautifully woven from personal narrative, reimagined history, and fresh, emotionally charged reportage, Between the World and Me clearly illuminates the past, bracingly confronts our present, and offers a transcendent vision for a way forward.
Author: Yuval Noah Harari
Publisher: HarperCollins
ISBN: 0062464353
Category : Science
Languages : en
Pages : 245
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Book Description
Official U.S. edition with full color illustrations throughout. NEW YORK TIMES BESTSELLER Yuval Noah Harari, author of the critically-acclaimed New York Times bestseller and international phenomenon Sapiens, returns with an equally original, compelling, and provocative book, turning his focus toward humanity’s future, and our quest to upgrade humans into gods. Over the past century humankind has managed to do the impossible and rein in famine, plague, and war. This may seem hard to accept, but, as Harari explains in his trademark style—thorough, yet riveting—famine, plague and war have been transformed from incomprehensible and uncontrollable forces of nature into manageable challenges. For the first time ever, more people die from eating too much than from eating too little; more people die from old age than from infectious diseases; and more people commit suicide than are killed by soldiers, terrorists and criminals put together. The average American is a thousand times more likely to die from binging at McDonalds than from being blown up by Al Qaeda. What then will replace famine, plague, and war at the top of the human agenda? As the self-made gods of planet earth, what destinies will we set ourselves, and which quests will we undertake? Homo Deus explores the projects, dreams and nightmares that will shape the twenty-first century—from overcoming death to creating artificial life. It asks the fundamental questions: Where do we go from here? And how will we protect this fragile world from our own destructive powers? This is the next stage of evolution. This is Homo Deus. With the same insight and clarity that made Sapiens an international hit and a New York Times bestseller, Harari maps out our future.
Author: Theodore Roosevelt
Publisher: Legare Street Press
ISBN: 9781019297476
Category : History
Languages : en
Pages : 0
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Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author: Jennifer Lohmann
Publisher: Harlequin
ISBN: 1460324544
Category : Fiction
Languages : en
Pages : 195
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Book Description
He always does the right thing There's one exception to Karl Milek's rule—the Vegas weekend that leaves him with a night to remember, and a beautiful new wife he'd rather forget. Those divorce papers are put on hold, however, when Vivian shows up on his doorstep pregnant. Karl offers her shelter and everything else she needs until their baby is born. Yet soon he realizes that he could definitely get used to seeing Vivian in the mornings, sharing dinner with her at night…and inhaling her jasmine scent. But he doesn't think he can risk giving his wife the one thing she wants most—his love.
Author: Sarah Manguso
Publisher: Macmillan + ORM
ISBN: 1429940980
Category : Biography & Autobiography
Languages : en
Pages : 194
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Book Description
A poet and author recounts her nine-year struggle with a rare autoimmune disease in this spare and unsparing memoir of illness and recovery. At twenty-one, just as she was starting to comprehend the puzzles of adulthood, Sarah Manguso was faced with another: a wildly unpredictable disease that appeared suddenly and tore through her twenties, paralyzing her for weeks at a time, programming her first to expect nothing from life and then, furiously, to expect everything. In this captivating story, Manguso recalls her struggle: arduous blood cleansings, collapsed veins, multiple chest catheters, the deaths of friends and strangers, addiction, depression, and, worst of all for a writer, the trite metaphors that accompany prolonged illness. A book of tremendous grace and self-awareness, The Two Kinds of Decay transcends the very notion of what an illness story can and should be. Praise for The Two Kinds of Decay A New York Times Book Review Editors’ Choice Best Book of the Year, San Francisco Chronicle and Time Out Chicago “Moving . . . a fiercely truthful memoir.” —The Boston Globe “Hers is not a day-by-day description of this grueling time, but an impressionistic text filled with bright, poetic flashes. . . . Many sick people learn to live in the moment, but the power of Manguso’s writing makes that truism revelatory.” —The Washington Post Book World “Sarah Manguso has miraculously elevated the act of memory. She has found honesty, fear, longing and beauty in every moment of her young life, giving this book an intensity found nowhere else. You put it down panting with wonder and grief, but never with pity. A breakthrough in the memoir, and in writing.” —Andrew Sean Greer
Author: National Intelligence Council
Publisher: Cosimo Reports
ISBN: 9781646794973
Category :
Languages : en
Pages : 158
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Book Description
"The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come." -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading.
Author: John Pavlovitz
Publisher:
ISBN: 9780578682501
Category : Religion
Languages : en
Pages : 276
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Book Description
Over the past few years, John Pavlovitz's blog, Stuff That Needs To Be Said, has become a virtual hub for millions of people from all over the world, drawn there by his clear, compelling words on compassion, equity, love, and justice. This expansive, like-hearted community transcends race, orientation, gender, religious tradition, political affiliation, and nation of origin--and finds its affinity in the deeper place of our shared humanity, which is the True North of his writing. This collection lovingly pulls together some of John's most widely-read and most beloved essays on faith, politics, grief, and the elemental parts of being human. It is an encouraging, inspiring, challenging storehouse of "stuff that needs to be said."
Author: Carolyn Finney
Publisher: UNC Press Books
ISBN: 1469614480
Category : Nature
Languages : en
Pages : 194
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Book Description
Black Faces, White Spaces: Reimagining the Relationship of African Americans to the Great Outdoors
