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Author: Naoyuki Taniguchi
Publisher: Springer Science & Business Media
ISBN: 4431779248
Category : Science
Languages : en
Pages : 255
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Book Description
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.
Author: Peng George Wang
Publisher: CRC Press
ISBN: 9780824705381
Category : Science
Languages : en
Pages : 696
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Book Description
US, Canadian, and Chinese chemists summarize recent research into the synthesis, principles, and applications of carbohydrates for graduate students and researchers in carbohydrate chemistry, biochemistry, medicinal chemistry, and glycobiology. The topics include solid phase oligosaccharide synthesis, the chemical synthesis of bioactive steroidal saponins, the chemistry and biology of multi-valent saccharide displays, structures and mechanisms of action of aminoglycoside antibiotics, synthesizing glycosaminoglycans, glycosyltransferases in oligosaccharide synthesis, and metabolic substrate engineering as a tool for glycobiology Glycochemistry: Principles, Synthesis, and Applications presents methods used in the development of carbohydrate-based therapeutics. It highlights applications in chemical and enzymatic synthesis of complex carbohydrates, carbohydrate function, and carbohydrate-mediated biological recognition processes. There are practical examples on the development of carbohydrate-based pharmaceuticals and polymers for commercial use. The text also emphasizes the role of carbohydrates as key elements in modern molecular recognition processes.
Author: Naoyuki Taniguchi
Publisher: Springer Science & Business Media
ISBN: 4431779248
Category : Science
Languages : en
Pages : 255
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Book Description
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.
Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category : Medical
Languages : en
Pages : 694
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Book Description
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Els J. M. Van Damme
Publisher: Frontiers Media SA
ISBN: 2889715213
Category : Science
Languages : en
Pages : 491
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Book Description
Author: Minoru Fukuda
Publisher: IRL Press
ISBN:
Category : Literary Criticism
Languages : en
Pages : 440
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Book Description
Glycobiology: A Practical Approach describes the essential analytical techniques required to study glycoproteins and will be an important practical guide for all researchers, including those in the pharmaceutical industry, working in this field.
Author: Elizabeth Yuriev
Publisher: CRC Press
ISBN: 1439854602
Category : Medical
Languages : en
Pages : 351
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Book Description
Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on: X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking Alternative techniques for yielding structural information on carbohydrates from complex biological samples Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection
Author: Inka Brockhausen
Publisher: Springer Science & Business Media
ISBN: 1597451673
Category : Science
Languages : en
Pages : 388
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Book Description
Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell.
Author: Zhongping Tan
Publisher: Royal Society of Chemistry
ISBN: 1782623337
Category : Science
Languages : en
Pages : 441
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Book Description
Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.
Author: Martin G. Hicks
Publisher:
ISBN: 9783832539481
Category : Bioinformatics
Languages : en
Pages : 0
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Book Description
The Beilstein Symposia address contemporary issues in the chemical and related sciences by employing and interdisciplinary approach. Scientists from a wide range of areas are invited to present aspects of their work for discussion, with the aim of not only advancing sciences, but also enhancing interdisciplinary communication. Traditionally, the Beilstein Symposia are kept small with up to 50 participants to provide a convivial atmosphere for the both lectures and lively discussions and the ready exchange of thoughts and ideas. The appreciation and understanding of the role that carbohydrates play in nature has grown over the last few years driven by the advances in our ability to analyze and synthesize their structures. Their role not only as primary energy-storage molecules but also as structural modifiers of e.g. glycoproteins and glycolipids, as well as in physiological and pathological events such as adherence, cell-cell interaction, transport, signaling and protection is becoming clearer and more accessible to researchers. Over the last decade the fields of glycobiology and glycochemistry in combination with in-silico applications have been augmented by a further field - glycomics. A major aim of glycomics research is to achieve a comprehensive identification and characterization of the repertoire of glycan structures present in an organism, cell or tissue at a defined time. The continual improvement of analysis methods and computational techniques leads to glycan characterization and identification with increased depth, speed and efficiency but also generates ever increasing amounts of data of variable quality and completeness. Thus the many web-accessible repositories result in a highly fragmented knowledgebase which in consequence complicates the development and application of bioinformatics tools for the analysis of this data. This situation has led to a general consensus that community wide efforts should be spent towards consolidating and systematizing the collective knowledgebase with integration of universal bioinformatics tools for both the representation, mining as well as annotation of experimental data sets to advance and interface glycomics with related genomics and proteomics projects. Additionally, both experimentalists and bioinformaticians also expressed their demands for data reporting practices that include the comprehensive description of conditions, techniques and experimental results to enable researchers to evaluate the degree of structural definitions, to interpret the results and to reproduce the experiments. This 3rd Beilstein Glyco-Bioinformatics Symposium brought together those scientists that produce data with those that use the data and make it available to the community. In particular, in their presentations speakers delivered insights into the diverse physiological and structural subtleties of sugars by covering aspects such as: structure-function relationships of carbohydrates, modeling carbohydrate structure and carbohydrate interactions with other biomacromolecules, deciphering carbohydrate signals, carbohydrate identification, annotation and analysis, metadata for the description of glycomics experiments, software tools for data mining and analysis.
Author: Joshua Finkelstein
Publisher:
ISBN:
Category :
Languages : en
Pages : 53
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Book Description
