Genetics of Human Histocompatibility Antigens and Their Relation to Disease PDF Download
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Author: E. Thorsby
Publisher: Ardent Media
ISBN: 9780842270625
Category : Medical
Languages : en
Pages : 236
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Book Description
Author: E. Thorsby
Publisher: Ardent Media
ISBN: 9780842270625
Category : Medical
Languages : en
Pages : 236
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Narinder K Mehra
Publisher: Boydell & Brewer Ltd
ISBN: 9788184488708
Category : Medical
Languages : en
Pages : 616
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Book Description
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
Author: Michael J. Browning
Publisher: Taylor & Francis
ISBN:
Category : Medical
Languages : en
Pages : 472
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Book Description
This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Author: E. Thorsby
Publisher:
ISBN:
Category :
Languages : en
Pages : 231
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Book Description
Author: George Snell
Publisher: Elsevier
ISBN: 0323151310
Category : Medical
Languages : en
Pages : 416
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Book Description
Histocampatibility covers the genetic, immunologic, and the chemical studies on allograft rejection process. The book is composed of 13 chapters that describe how these studies relate to medicine, organ transplantation in man, basic immunology, cell membrane structures, and cancer research. After briefly dealing with the early studies on isografts and allografts in laboratory animals, the book describes the histogenetic methods of gene manipulation and transplantation that permit identification of individual histocompatibility loci. The following chapter examines the significance of congenic resistant lines in determining the diversity of histocompatibility loci and allele and immune response genes. Other chapters present immunogenetic and serological methods, as well as the applications of these methods in studying alloantigens and H-2 complex loci and of immunogenetic methods to human. The book also discusses the practical implication of HLA immunogenetics in organ transplantation and describes the biochemical, immunochemical, and dynamic properties of alloantigens. A chapter discusses the associations between HLA system and disease and the various mechanisms that have been suggested to explain these associations. The last chapter focuses on allograft reaction and on established facts of cellular immunity. This book is a valuable source of information for researchers in the fields of medicine, organ transplantation in man, basic immunology, cell membrane structures, and cancer.
Author: Jeffrey L Bidwell
Publisher: World Scientific
ISBN: 1783262109
Category : Medical
Languages : en
Pages : 493
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Book Description
This invaluable book provides comprehensive coverage of contemporary serological, cellular and molecular methodologies in histocompatibility testing, and their application to human organ transplantation and transfusion. The contributors are internationally respected authorities in histocompatibility and immunogenetics, and are closely involved in the development or application of state-of-the-art technologies. The first three sections of the book are primarily intended for use as a bench manual for histocompatibility testers, immunologists and immunogeneticists; the fourth and fifth sections, on selection of donors and statistical methods, will further assist medical practitioners involved in clinical transplantation and its outcome. The final section of the book reviews the genetics and clinical relevance of minor histocompatibility antigens.
Author: Jerzy K. Kulski
Publisher: MDPI
ISBN: 3039280724
Category : Science
Languages : en
Pages : 374
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Book Description
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
Author: B. Parham
Publisher: Springer Science & Business Media
ISBN: 9400958943
Category : Science
Languages : en
Pages : 250
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Book Description
The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.
Author: Gabriel S Panayi
Publisher: Butterworth-Heinemann
ISBN: 1483164616
Category : Medical
Languages : en
Pages : 417
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Book Description
Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.
