Genetic Toxicology of Environmental Chemicals PDF Download
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Author: Clases Ramel
Publisher: John Wiley & Sons
ISBN: 9780471860204
Category :
Languages : en
Pages : 674
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Book Description
Author: Clases Ramel
Publisher: John Wiley & Sons
ISBN: 9780471860204
Category :
Languages : en
Pages : 674
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Book Description
Author: ROSENKRANZ HS.
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Claes Ramel
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 686
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Author:
Publisher:
ISBN: 9780845101902
Category : Carcinogenesis
Languages : en
Pages : 0
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Book Description
This volume and the accompanying one, Genetic Toxicology of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis, constitute the Proceedings of the Fourth International Conference on Environmental Mutagens, which was held in Stockholm, June 24- 28, 1985. The primary emphasis is the identification of genetically hazardous chemicals in the environment and the choice of suitable test systems for that purpose. Much of the activities and discussions concerned the relationship between mutagenicity and carcinogenicity, and this in turn hinged on the correlation observed between short term tests and animal cancer data. The ambition to construct a standardized set of short-term tests which would be able to predict carcinogenic properties of environmental chemicals has turned out to be more complicated to achieve than one had foreseen. Above all, it is obvious that the induction of cancer is a multistep process, which cannot be embraced by a simplistic, mutagenicity testing procedure. Exactly the same discussions concerning the relationship between mutagenicity and carcinogenicity have taken place at previous international conferences, and the present conference is no exception.
Author:
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ISBN: 9780845101919
Category :
Languages : en
Pages : 0
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 637
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Author: D. Brusick
Publisher: Springer Science & Business Media
ISBN: 9780306425325
Category : Medical
Languages : en
Pages : 312
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Book Description
The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309112982
Category : Science
Languages : en
Pages : 300
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Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: Urs A. Boelsterli
Publisher: CRC Press
ISBN: 9780849372728
Category : Medical
Languages : en
Pages : 424
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Book Description
A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology
Author: Joseph LaDou
Publisher: McGraw Hill Professional
ISBN: 0071443134
Category : Medical
Languages : en
Pages : 865
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Book Description
Up-to-the-minute, thorough, clinical coverage of common and important occupational and environmental diseases, injuries, and exposures Complete, yet concise, this clinically focused guide offers the definitive overview of common occupational and environmental illnesses, covering their diagnosis and treatment-plus preventive and remedial measures in the workplace and community. With its practical format and emphasis on fundamental topics, CURRENT Occupational and Environmental Medicine is just as essential for students and residents as it is for practicing physicians. You can count on the new fourth edition to deliver the bottom-line answers you need to stay on track in this complex, fast-breaking field. Features: The latest OSHA/NIOSH guidelines for occupational exposure standards Detailed diagnostic checklist for major diseases, injuries, and exposure that help expedite diagnosis and treatment The most clinically relevant perspectives on disability prevention-required reading for the occupational physician Skill-building insights on the importance of ergonomics in the workplace A step-by-step review of how to effectively manage an occupational health and safety program Details on substance abuse and employee assistance programs, health risk analysis, and the legal aspects of occupational and environmental medicine Preventive approaches to terrorist attacks on industry Information-packed primer on epidemiology and biostatistics for the occupational and environmental health specialist Up-to-date references with PMID numbers and peer-reviewed websites
