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Author: Rafael Covenãs Rodríguez
Publisher:
ISBN: 9788178952918
Category : Neuropeptides
Languages : en
Pages : 362
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Book Description
Neuropeptides is one of the disciplines in the field of Neuroscience that has been largely developed from the seventies and one that is foreseen to develop to possibly unimaginable heights in the near future, since neuropeptides are widespread distributed in the central and peripheral nervous systems and they are involved in many pathologies (Parkinson s disease, Alzheimer s disease, schizophrenia, depression&). Growing numbers of researches (cell biologists, biochemists, geneticists, histologists, pharmacologists, physiologists, psychiatrists, pathologists, immunologists, neurobiologists, psychologists&) are currently involved in this discipline and increasingly sophisticated methods for its study are becoming available. Our main aims in writing this book on neuropeptides were the following: a) to review the general data that exist on neuropeptides; b) to show the results found in several research works on the distribution and functions of neuropeptides; and c) to show the future perspectives on neuropeptide research. In this sense, the text has been divided in four parts. The first entitled Introduction to Neuropeptides includes the general data on neuropeptides such as: concepts of neuropeptide, neurotransmitter, neuromodulator and neurohormone, families of neuropeptides, phylogeny and ontogeny of neuropeptides, biosynthesis of neuropeptides, release and receptors of neuropeptides, enzymatic degradation of neuropeptides, methodologies used in the study of neuropeptides and distribution of neuropeptides (Chapter 1). The second part called Distribution of Neuropeptides includes the results obtained by different research groups on the distribution of neuropeptides in the cat spinal cord, brainstem, diencephalon and cerebral cortex, as well as on the distribution of neuropeptides in the dog brainstem and diencephalon and in the alpaca brainstem (Chapters 2-7). The third part deals with the Functions of the Neuropeptides and includes a review chapter on such functions (involvement of neuropeptides in pain, analgesia, thermoregulation, glucoregulation, food and water intake, immunoregulation, wakefulness and sleep, learning and memory) (Chapter 8) and a specific chapter on the implication of neuropeptides in cardiovascular control (Chapter 9). The aim of the fourth part was to show the Pathophysiology of the Neuropeptides . Thus, there is a chapter in which the involvement of neuropeptides in several pathologies such as asthma, arthritis, Alzheimer s disease, Parkinson s disease, alcoholism, schizophrenia, depression, stress and suicide is reviewed. In such chapter, the implication of neuropeptides in aging will be also reviewed (Chapter 10). Moreover, in the fourth part three specific chapters will be focused on the involvement of neuropeptides in migraine and Parkinson s and Alzheimer s disease (Chapters 11, 12), as well as on the implications of neuropeptides and NK-1 receptor antagonists in cancer research (Chapter 13). This book is directed not only to researchers interested in the field of neuropeptides, but to Life and Health Sciences Ph.D. students. For this reason, we have included three review chapters on the general concerning of neuropeptides (Chapter 1), the functional implications of neuropeptides (Chapter 8) and on the pathophysiology of the neuropeptides (Chapter 10). We hope that this text help to students to be enthusiasm in the study of neuropeptides and to introduce them in this field, since much remains to be studied on the distribution and functions of neuropeptides. Finally, we thank to Mercedes de León the help received before and during the redaction of this book.
Author: Rafael Covenãs Rodríguez
Publisher:
ISBN: 9788178952918
Category : Neuropeptides
Languages : en
Pages : 362
Get Book Here
Book Description
Neuropeptides is one of the disciplines in the field of Neuroscience that has been largely developed from the seventies and one that is foreseen to develop to possibly unimaginable heights in the near future, since neuropeptides are widespread distributed in the central and peripheral nervous systems and they are involved in many pathologies (Parkinson s disease, Alzheimer s disease, schizophrenia, depression&). Growing numbers of researches (cell biologists, biochemists, geneticists, histologists, pharmacologists, physiologists, psychiatrists, pathologists, immunologists, neurobiologists, psychologists&) are currently involved in this discipline and increasingly sophisticated methods for its study are becoming available. Our main aims in writing this book on neuropeptides were the following: a) to review the general data that exist on neuropeptides; b) to show the results found in several research works on the distribution and functions of neuropeptides; and c) to show the future perspectives on neuropeptide research. In this sense, the text has been divided in four parts. The first entitled Introduction to Neuropeptides includes the general data on neuropeptides such as: concepts of neuropeptide, neurotransmitter, neuromodulator and neurohormone, families of neuropeptides, phylogeny and ontogeny of neuropeptides, biosynthesis of neuropeptides, release and receptors of neuropeptides, enzymatic degradation of neuropeptides, methodologies used in the study of neuropeptides and distribution of neuropeptides (Chapter 1). The second part called Distribution of Neuropeptides includes the results obtained by different research groups on the distribution of neuropeptides in the cat spinal cord, brainstem, diencephalon and cerebral cortex, as well as on the distribution of neuropeptides in the dog brainstem and diencephalon and in the alpaca brainstem (Chapters 2-7). The third part deals with the Functions of the Neuropeptides and includes a review chapter on such functions (involvement of neuropeptides in pain, analgesia, thermoregulation, glucoregulation, food and water intake, immunoregulation, wakefulness and sleep, learning and memory) (Chapter 8) and a specific chapter on the implication of neuropeptides in cardiovascular control (Chapter 9). The aim of the fourth part was to show the Pathophysiology of the Neuropeptides . Thus, there is a chapter in which the involvement of neuropeptides in several pathologies such as asthma, arthritis, Alzheimer s disease, Parkinson s disease, alcoholism, schizophrenia, depression, stress and suicide is reviewed. In such chapter, the implication of neuropeptides in aging will be also reviewed (Chapter 10). Moreover, in the fourth part three specific chapters will be focused on the involvement of neuropeptides in migraine and Parkinson s and Alzheimer s disease (Chapters 11, 12), as well as on the implications of neuropeptides and NK-1 receptor antagonists in cancer research (Chapter 13). This book is directed not only to researchers interested in the field of neuropeptides, but to Life and Health Sciences Ph.D. students. For this reason, we have included three review chapters on the general concerning of neuropeptides (Chapter 1), the functional implications of neuropeptides (Chapter 8) and on the pathophysiology of the neuropeptides (Chapter 10). We hope that this text help to students to be enthusiasm in the study of neuropeptides and to introduce them in this field, since much remains to be studied on the distribution and functions of neuropeptides. Finally, we thank to Mercedes de León the help received before and during the redaction of this book.
Author: Timothy G. Geary
Publisher: Springer Science & Business Media
ISBN: 1441969020
Category : Medical
Languages : en
Pages : 246
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Book Description
The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.
Author: S. Charles Schulz
Publisher: Oxford University Press
ISBN: 019937807X
Category : Medical
Languages : en
Pages : 401
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Book Description
Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.
Author: Josh Dubnau
Publisher: Cambridge University Press
ISBN: 1107009030
Category : Medical
Languages : en
Pages : 309
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Book Description
A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Author: Bernice A. Levine
Publisher: Nova Publishers
ISBN: 9781600216404
Category : Medical
Languages : en
Pages : 316
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Book Description
The explosion of research activity in the field of neuropeptides has led to the idenfication of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.
Author: John P. Bilezikian
Publisher: Academic Press
ISBN: 0080568750
Category : Medical
Languages : en
Pages : 2074
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Book Description
Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Author: Richard E. Brown
Publisher: Cambridge University Press
ISBN: 9780521426657
Category : Science
Languages : en
Pages : 434
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Book Description
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Author: Mikhail Soloviev
Publisher: John Wiley & Sons
ISBN: 0470196491
Category : Science
Languages : en
Pages : 432
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Book Description
The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.
Author: Felix-Martin Werner
Publisher: Bentham Science Publishers
ISBN: 1681082152
Category : Medical
Languages : en
Pages : 93
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Book Description
Schizoaffective disorder is a psychotic disease with schizophrenic and affective i.e. depressive and/or manic symptoms. The disease can result in different patient outcomes depending upon the treatment applied. Patients suffering from the disease have in increased vulnerability towards stress and need an appropriate prophylactic medication so that they can perform social and maybe professional activities. Classical Neurotransmitters and Neuropeptides involved in Schizoaffective Disorder is a brief monograph that gives readers an overview of frequent psychotic diseases affecting patients. The contents of the monograph include details about biochemical alterations of classical neurotransmitters and neuropeptides in specific regions of the human brain, the susceptible genes and cellular mechanisms behind schizoaffective disorder, the neural networks of schizoaffective disorder and prophylactic pharmacotherapies administered to patients. Three case reports which demonstrate the alterations of classical neurotransmitters and neuropeptides in the brain are also presented. This monograph is a useful guide for medical residents and clinicians in training who wish to understand the basics about treating patients suffering from schizoaffective disorder.
Author: Luis De Lecea
Publisher: Springer Science & Business Media
ISBN: 0387254463
Category : Medical
Languages : en
Pages : 438
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Book Description
The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.
