Drug-Induced Liver Injury PDF Download
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Author:
Publisher: Academic Press
ISBN: 0128173173
Category : Medical
Languages : en
Pages : 290
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Book Description
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Author:
Publisher: Academic Press
ISBN: 0128173173
Category : Medical
Languages : en
Pages : 290
Get Book Here
Book Description
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Author: Vincent T. Andriole
Publisher: Elsevier
ISBN: 0080525784
Category : Medical
Languages : en
Pages : 540
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Book Description
Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. New quinolones are continually being developed as bacterial species develop resistance to existing quinolones. This book presents the most current information available in our continual struggle to conquer disease. Over time, bacteria become resistant to medicines that are used to combat them. Because of this, the medical world is always in search of new and improved ways to battle these disease-causing bacteria. Quinolones are at the forefront of this research. Edited by one of the world's foremost authorities on the subject, the third edition of this highly successful title will serve as a valuable tool for primary care physicians and researchers interested in a comprehensive, up-to-date reference on the chemistry, mechanisms of action, development of resistance, and clinical efficacy of both currently available and newer quinolone compounds under investigation. This is the eagerly anticipated fully revised edition of the standard reference in the field. - Eagerly anticipated updated edition of noted title covering synthetic microbial agents that are useful against infectious disease, particularly those caused by bacteria - Edited by one of the foremost experts in the field of quinolone research and infectious disease - History of quinolones, chemistry & mechanisms of action, pharmacology, safety aspects - Role of quinolones in treating various types of infections, including respiratory infections, gastrointestinal infections, urinary tract infections, prostatitis, STDs and bacterial meningitis as well as their use in immunocompromised patients
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781719520
Category : Medical
Languages : en
Pages : 850
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Book Description
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Author: Jón Karlsson
Publisher:
ISBN: 9780955887345
Category : Achilles tendon
Languages : en
Pages : 426
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Book Description
Author: Stefan Pieper
Publisher: Springer
ISBN: 9783030741723
Category : Medical
Languages : en
Pages : 70
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Book Description
In this book, Stefan Pieper supports doctors and therapists in easily diagnosing FQAD and in better and more adequately dealing with FQAD patients. Fluoroquinolones, as one of the most common and effective groups of antibiotics, are known to have a distinct spectrum of side effects. These adverse effects are rare in percentage terms, but frequent in absolute numbers due to the enormous quantities of prescriptions. Because they are usually quite severe and wide-ranging, they tend to run like a syndrome and have been classified by the FDA as a separate condition, the FQAD, because of their frequency, severity and risk of disability. This book presents for the first time a comprehensive description and classification of the clinical picture and a proposal for a clinical diagnostic tool based on diagnostic criteria.
Author: Allan R. Ronald
Publisher: Birkhäuser
ISBN: 3034881037
Category : Medical
Languages : en
Pages : 263
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Book Description
The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry.
Author: Boyan B. Bonev
Publisher: John Wiley & Sons
ISBN: 111994077X
Category : Science
Languages : en
Pages : 288
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Book Description
AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.
Author: Jay S. Cohen
Publisher: Square One Publishers, Inc.
ISBN: 0757054692
Category : Self-Help
Languages : en
Pages : 205
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Book Description
While the news about taking too many antibiotics is now common knowledge, there is another underlying danger that the public is not aware of. As beneficial as this class of drugs are, there is a widely prescribed family of antibiotics that is highly destructive. Called fluoroquinolones, they are better known under the names Cipro and Levaquin (as well as four others). What You Must Know About the Hidden Dangers of Antibiotics, has two main goals. The first is to expose the truly destructive capability of these drugs to cause serious, sometimes long term and permanent injuries. The capacity of these drugs for such damage has been attested to by the government’s own watchdog agency, the FDA. Hundreds of patients, many of whom are quoted in this book, have confirmed their long-lasting injuries to the book’s author, Dr. Jay Cohen, while many hundreds more have been ignored or dismissed by their own physicians. As this book will show, being brushed off and dismissed as simple side effects essentially allows these manufactures to hide these problems from public view. The second goal of this book is to provide other safer and effective remedies, solutions, and considerations that may help end the suffering experienced by patients suffering from these dangerous side effects--that can affect many human systems including the musculoskeletal, nervous, psychiatric, gastrointestinal, and others. To do this we explain how these dangerous antibiotics work, and particularly how they injure. By understanding the underlying problems, the alternatives offered in this book can help people potentially reduce their pain reduction, clear up persistent antibiotic-based health issues, and just as important, give them hope. Because so many doctors do not carefully read the FDA’s dire warnings about the risks these specific antibiotics pose, there is little likely patients will be know why they are having such serious reactions. With What You Must Know About the Hidden Dangers of Antibiotics, they may have the answer they are looking for.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309175771
Category : Medical
Languages : en
Pages : 276
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Book Description
The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.
Author: Jay Cohen
Publisher:
ISBN: 9781518626869
Category :
Languages : en
Pages : 206
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Book Description
This book is about the powerful, sometimes lifesaving, yet sometimes highly destructive antibiotics known as fluoroquinolones. Best known of these drugs are Cipro (ciprofloxacin) and Levaquin (levofloxacin), as well as four others. This book, How We Can Halt the Cipro and Levaquin Catastrophe: the Worst Medication Disaster in U.S. History, has two main goals. The first goal is to alert patients and doctors of the truly destructive capability of these drugs to cause serious, sometimes long term, sometimes permanent injuries. The capacity of these drugs for such damage has been attested by the U.S. Food and Drug Administration and others many times and is by now incontrovertible. Hundreds of patients, many of whom are quoted in this book, have confirmed their long-lasting injuries to me, while many hundreds more have been ignored or dismissed by their doctors. This must stop. Ignoring these problems has only made the problem worse. My second goal in writing How We Can Halt the Cipro and Levaquin Catastrophe: the Worst Medication Disaster in U.S. History is to stimulate the interest of government, the drug industry, medical institutions and all others for any and all ideas regarding remedies, solutions, and any other ideas that may help end the suffering experienced by patients with the Fluoroquinolone Toxicity Syndrome that can affect many human systems including the musculoskeletal, nervous, psychiatric, gastrointestinal, and others. As you will see, I have offered some ideas for therapies that may provide benefit to some of the injured. I think it is imperative that we follow a trail that may lead us to an understanding of how these drugs work and particularly how they injure, and most of all how we might help people heal, obtain pain reduction and hope. Thousands of lives, young and old, depend on the efforts that we make.
