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Author: Alexander V. Karasev
Publisher: Springer Science & Business Media
ISBN: 3540708685
Category : Medical
Languages : en
Pages : 126
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Book Description
In recent years, plants have been increasingly explored for production of biomedicines and vaccine components. The two main advantages of plant systems are low cost and a greater potential for scalability as compared to microbial or animal systems. An additional advantage from the public health point of view is high safety compared to animal systems, which is important for vaccine production: there are no known plant pathogens capable of replicating in animals, and in humans in particular. A particular antigen or a protein has to be expressed in a plant using one of many available platforms; this antigen/protein subsequently needs to be purified or processed, and later formulated into a vaccine or a therapeutic; these need to be delivered to a human or animal body via an appropriate route. Naturally, all these vaccines and therapeutics must be subjected to regulatory approvals prior to their use. Thus, the challenge is to adapt plant-based platforms for production of cost-efficient biomedicals that can be approved by FDA for use as vaccine components or therapeutics which will be competitive against existing vaccines and drugs. This volume attempts to address the entire spectrum of challenges facing the nascent field of plant-based biomedicals, from the selection of an appropriate production platform to specific methods of downstream processing and regulatory approval issues.
Author: Alexander V. Karasev
Publisher: Springer Science & Business Media
ISBN: 3540708685
Category : Medical
Languages : en
Pages : 126
Get Book Here
Book Description
In recent years, plants have been increasingly explored for production of biomedicines and vaccine components. The two main advantages of plant systems are low cost and a greater potential for scalability as compared to microbial or animal systems. An additional advantage from the public health point of view is high safety compared to animal systems, which is important for vaccine production: there are no known plant pathogens capable of replicating in animals, and in humans in particular. A particular antigen or a protein has to be expressed in a plant using one of many available platforms; this antigen/protein subsequently needs to be purified or processed, and later formulated into a vaccine or a therapeutic; these need to be delivered to a human or animal body via an appropriate route. Naturally, all these vaccines and therapeutics must be subjected to regulatory approvals prior to their use. Thus, the challenge is to adapt plant-based platforms for production of cost-efficient biomedicals that can be approved by FDA for use as vaccine components or therapeutics which will be competitive against existing vaccines and drugs. This volume attempts to address the entire spectrum of challenges facing the nascent field of plant-based biomedicals, from the selection of an appropriate production platform to specific methods of downstream processing and regulatory approval issues.
Author: Maarten J. Chrispeels
Publisher: Jones & Bartlett Learning
ISBN: 9780763715861
Category : Nature
Languages : en
Pages : 600
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Book Description
This book integrates many fields to help students understand the complexity of the basic science that underlies crop and food production.
Author: Debmalya Barh
Publisher: CRC Press
ISBN: 1466585315
Category : Medical
Languages : en
Pages : 719
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Book Description
Merging topical data from recently published review and research articles, as well as the knowledge and insight of industry experts, Omics Applications in Crop Science delves into plant science, and various technologies that use omics in agriculture. This book concentrates on crop breeding and environmental applications, and examines the applicatio
Author: A.D. Arencibia
Publisher: Elsevier
ISBN: 008053905X
Category : Business & Economics
Languages : en
Pages : 283
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Book Description
Plant biotechnology offers important opportunities for agriculture, horticulture, and the pharmaceutical and food industry by generating transgenic varieties with altered properties. This is likely to change farming practice and reduce the potential negative impact of plant production on the environment. This volume shows the worldwide advances and potential benefits of plant genetic engineering focusing on the third millennium. The authors discuss the production of transgenic plants resistant to biotic and abiotic stress, the improvement of plant qualities, the use of transgenic plants as bioreactors, and the use of plant genomics for genetic improvement and gene cloning. Unique to this book is the integrative point of view taken between plant genetic engineering and socioeconomic and environmental issues. Considerations of regulatory processes to release genetically modified plants, as well as the public acceptance of the transgenic plants are also discussed.This book will be welcomed by biotechnologists, researchers and students alike working in the biological sciences. It should also prove useful to everyone dedicated to the study of the socioeconomic and environmental impact of the new technologies, while providing recent scientific information on the progress and perspectives of the production of genetically modified plants.The work is dedicated to Professor Marc van Montagu.
Author: Praveen K. Saxena
Publisher: Springer Science & Business Media
ISBN: 9401597790
Category : Science
Languages : en
Pages : 270
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Book Description
The `plant' is often the most neglected part of plant-based medicine. Throughout time, humans have searched, collected, and effectively used plants for healing. Currently, the medicinal plant-based business is flourishing at a dramatic pace and at the expense of an already declining population of plant species, many of which are on the verge of extinction. In spite of this history and popularity, the mystery of what transforms a plant into a medicinal plant persists, and there are chronic problems with ensuring the safety and efficacy of medicinal plant products. Therefore, there is a real need for a full characterization of medicinal plant species and for the development and application of novel technologies for the production of plant-based medicines. This book highlights some of the recent advances and new approaches to the development of technologies for plant-based medicines and is intended to stimulate new discussions among researchers, regulatory authorities, and pharmaceutical organizations, leading to significant advancements in the field.
Author: Santosh Kumar Upadhyay
Publisher: John Wiley & Sons
ISBN: 1119875102
Category : Science
Languages : en
Pages : 548
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Book Description
PLANTS AS BIOREACTORS FOR INDUSTRIAL MOLECULES An incisive and practical discussion of how to use plants as bioreactors In Plants as Bioreactors for Industrial Molecules, a team of distinguished researchers delivers an insightful and global perspective on the use of plants as bioreactors. In the book, you’ll find coverage of the basic, applied, biosynthetic, and translational approaches to the exploitation of plant technology in the production of high-value biomolecules. The authors focus on the yield and quality of amino acids, vitamins, and carbohydrates. The authors explain how high-value biomolecules enable developers to create cost-effective biological systems for the production of biomolecules useful in a variety of sectors. They provide a holistic approach to plant-based biological devices to produce natural molecules of relevance to the health and agriculture industries. Readers will also find: A thorough overview of plants as bioreactors and discussions of molecular farming for the production of pharmaceutical proteins in plants Comprehensive explorations of plants as edible vaccines and plant cell culture for biopharmaceuticals Practical discussions of the production of attenuated viral particles as vaccines in plants and insecticidal protein production in transgenic plants Extensive treatment of the regulatory challenges involved in using plants as bioreactors Perfect for academics, scientists, and researchers in industrial microbiology and biotechnology, Plants as Bioreactors for Industrial Molecules will also earn a place in the libraries of biotechnology company professionals in applied product development.
Author: Kasi Azhakanandam
Publisher: Springer
ISBN: 1493922025
Category : Science
Languages : en
Pages : 467
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Book Description
In this book, authors who are experts in their fields describe current advances on commercial crops and key enabling technologies that will underpin future advances in biotechnology. They discuss state of the art discoveries as well as future challenges. Tremendous progress has been made in introducing novel genes and traits into plant genomes since the first creation of transgenic plants thirty years ago, and the first commercialization of genetically modified maize in 1996. Consequently, cultivation of biotech crops with useful traits has increased more than 100-fold from 1.7 million hectares in 1996 to over 175 million hectares globally in 2013. This achievement has been made possible by continued advances in understanding the basic molecular biology of regulatory sequences to modulate gene expression, enhancement of protein synthesis and new technologies for transformation of crop plants. This book has three sections that encompass knowledge on genetically modified (GM) food crops that are currently used by consumers, those that are anticipated to reach the market place in the near future and enabling technologies that will facilitate the development of next generation GM crops. Section I focuses only on genetically modified maize and soybean (3 chapters each), while Section II discusses the GM food crops rice, wheat, sorghum, vegetables and sugar cane. Section III covers exciting recent developments in several novel enabling technologies, including gene targeting, minichromosomes, and in planta transient expression systems.
Author: Allison R. Kermode
Publisher: John Wiley & Sons
ISBN: 1118801482
Category : Science
Languages : en
Pages : 496
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Book Description
A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.
Author:
Publisher: Elsevier
ISBN: 0444640479
Category : Science
Languages : en
Pages : 4876
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Book Description
Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science
Author: Nigel Halford
Publisher: John Wiley & Sons
ISBN: 0470021829
Category : Technology & Engineering
Languages : en
Pages : 316
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Book Description
Plant Biotechnology: Current and Future Uses of Genetically Modified Crops covers in detail the development, use and regulation of GM crops. Split into three sections, Part 1 introduces GM crops and describes the GM crops that are used commercially. Part 2 looks at new developments and methodologies in areas including potential applications of GM crops for the production of vaccines, enhanced nutritional value of GM food, and engineering resistance to fungal pathogens. Part 3 concludes by considering the key issues of safety and legislation, including allergenicity, environmental impacts, risk assessment and labelling. Key features: Covers the topic in depth and addresses key subject areas Takes a broad view of the current situation in different countries Examines the commercial application of plant biotechnology in the USA and China Covers two major areas of public concern: allergenicity and gene flow Covers new developments in plant research, safety and legislation aspects This book is essential reading for postgraduates and researchers in plant biotechnology and related sciences in Departments of Plant Science, Biotechnology, Bioscience, Environmental Science, Food Biosciences and Chemistry. It is also of interest for professionals working in the plant biotechnology industry or government professionals working in environmental policy.
