Statistical Methods in Genetic Epidemiology PDF Download
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Author: Duncan C. Thomas
Publisher: Oxford University Press
ISBN: 0199748055
Category : Medical
Languages : en
Pages : 458
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Book Description
This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.
Author: Duncan C. Thomas
Publisher: Oxford University Press
ISBN: 0199748055
Category : Medical
Languages : en
Pages : 458
Get Book Here
Book Description
This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.
Author: Geoffrey L. Greif
Publisher: Columbia University Press
ISBN: 0231540809
Category : Psychology
Languages : en
Pages : 327
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Book Description
The bond siblings develop in childhood may be vastly different from the relationship that evolves in adulthood. Driven by affection but also characterized by ambivalence and ambiguity, adult sibling relationships can become hurtful, uncertain, competitive, or exhausting though the undercurrents of love and loyalty remain. An approach that recognizes the positive aspects of the changing sibling relationship, as well as those that need improvement, can restore healthy ties and rebuild family closeness. With in-depth case studies of more than 260 siblings over the age of forty and interviews with experts on mental health and family interaction, this book offers vital direction for traversing the emotional terrain of adult sibling relations. It pursues a richer understanding of ambivalence, a normal though little explored feeling among siblings, and how ambiguity about the past or present can lead to miscommunication and estrangement. For both professionals and general readers, this book clarifies the most confounding elements of sibling relationships and provides specific suggestions for realizing new, productive avenues of friendship in middle and later life—skills that are particularly important for siblings who must cooperate to care for aging parents or give immediate emotional or financial support to other siblings or family members.
Author: May Friedman
Publisher: Routledge
ISBN: 0429017634
Category : Social Science
Languages : en
Pages : 360
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Book Description
Thickening Fat: Fat Bodies, Intersectionality, and Social Justice seeks to explore the multiple, variable, and embodied experiences of fat oppression and fat activisms. Moving beyond an analysis of fat oppression as singular, this book will aim to unpack the volatility of fat—the mutability of fat embodiments as they correlate with other embodied subjectivities, and the threshold where fat begins to be reviled, celebrated, or amended. In addition, Thickening Fat explores the full range of intersectional and liminal analyses that push beyond the simple addition of two or more subjectivities, looking instead at the complex alchemy of layered and unstable markers of difference and privilege. Cognizant that the concept of intersectionality has been filled out in a plurality of ways, Thickening Fat poses critical questions around how to render analysis of fatness intersectional and to thicken up intersectionality, where intersectionality is attenuated to the shifting and composite and material dimensions to identity, rather than reduced to an “add difference and stir” approach. The chapters in this collection ask what happens when we operationalize intersectionality in fat scholarship and politics, and we position difference at the centre and start of inquiry.
Author: Carol A. Padden
Publisher: Harvard University Press
ISBN: 0674283171
Category : Social Science
Languages : en
Pages : 148
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Book Description
Written by authors who are themselves Deaf, this unique book illuminates the life and culture of Deaf people from the inside, through their everyday talk, their shared myths, their art and performances, and the lessons they teach one another. Carol Padden and Tom Humphries employ the capitalized "Deaf" to refer to deaf people who share a natural language—American Sign Language (ASL—and a complex culture, historically created and actively transmitted across generations. Signed languages have traditionally been considered to be simply sets of gestures rather than natural languages. This mistaken belief, fostered by hearing people’s cultural views, has had tragic consequences for the education of deaf children; generations of children have attended schools in which they were forbidden to use a signed language. For Deaf people, as Padden and Humphries make clear, their signed language is life-giving, and is at the center of a rich cultural heritage. The tension between Deaf people’s views of themselves and the way the hearing world views them finds its way into their stories, which include tales about their origins and the characteristics they consider necessary for their existence and survival. Deaf in America includes folktales, accounts of old home movies, jokes, reminiscences, and translations of signed poems and modern signed performances. The authors introduce new material that has never before been published and also offer translations that capture as closely as possible the richness of the original material in ASL. Deaf in America will be of great interest to those interested in culture and language as well as to Deaf people and those who work with deaf children and Deaf people.
Author: Joanna Cannon
Publisher: Simon and Schuster
ISBN: 1501187406
Category : Fiction
Languages : en
Pages : 400
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Book Description
The bestselling author of The Trouble with Goats and Sheep delivers a suspenseful and emotionally satisfying novel “infused with warmth and humor” (People) about a lifelong friendship, a devastating secret, and the small acts of kindness that bring people together. There are three things you should know about Elsie. The first thing is that she’s my best friend. The second is that she always knows what to say to make me feel better. And the third thing…might take a bit more explaining. Eighty-four-year-old Florence has fallen in her flat at Cherry Tree Home for the Elderly. As she waits to be rescued, she thinks about her friend Elsie and wonders if a terrible secret from their past is about to come to light. If the charming new resident is who he claims to be, why does he look exactly like a man who died sixty years ago? From the acclaimed, bestselling author of The Trouble with Goats and Sheep, Three Things About Elsie “breathes with suspense, providing along the way piercing, poetic descriptions, countless tiny mysteries, and breathtaking little reveals…a rich portrait of old age and friendship stretched over a fascinating frame” (Kirkus Reviews, starred review). This is an “amusing and heartbreaking” (Publishers Weekly) story about forever friends on the twisting path of life who come to understand how the fine threads of humanity connect us all.
Author: Alessandra Ceretto
Publisher: Lulu.com
ISBN: 136509796X
Category :
Languages : en
Pages : 192
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Book Description
Author: Owen Wrigley
Publisher: Gallaudet University Press
ISBN: 9781563680649
Category : Health & Fitness
Languages : en
Pages : 316
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Book Description
Lays out the practical steps families can take to adjust to a loved one's hearing loss. The book shows how the exchange of information can be altered at fundamental levels, what these alterations entail, and how they can affect one's ability to understand and interpret spoken communication.
Author: Danny Ramadan
Publisher: Canongate Books
ISBN: 1838854673
Category : Fiction
Languages : en
Pages : 207
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Book Description
WINNER OF THE LAMBDA LITERARY AWARD FOR GAY FICTION Hussam and Wassim are teenage boys living in Syria during America’s 2003 invasion of Iraq. When a surprise discovery results in tragedy, their lives, and those of their families, are shattered. Wassim promises Hussam his protection, but ten years into the future, he has failed to keep his promise. Wassim is on the streets, seeking shelter from both the city and the civil war storming his country. Meanwhile Hussam, now on the other side of the world, remains haunted by his own ghosts, doing his utmost to drown them out with every vice imaginable. Split between war-torn Damascus and unforgiving Vancouver, The Foghorn Echoes is a tragic love story about coping with shared traumatic experience and devastating separation. As Hussam and Wassim come to terms with the past, they begin to realise the secret that haunts them is not the only secret that formed them.
Author: Adnan Badran
Publisher: Springer Nature
ISBN: 3030378349
Category : Education
Languages : en
Pages : 384
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Book Description
This book is the first major account of innovation and entrepreneurship in the Arab higher-education sector. It provides an update of the current situation and advances reasons for the under-performance of Arab universities in international ranking tables and the weaknesses of Arab economies. Specific proposals are made for upgrading curricula and assessment procedures as well as providing an environment that fosters innovation and entrepreneurial behaviour. The roles of university-based technology and business parks are examined, with examples of successful business partnerships in the Arab region, Europe, and North America. Opportunities for innovation and entrepreneurship have never been greater with the wealth of rapidly developing transformative technologies that are driving the international knowledge economy. This book puts forward proposals for the management and exploitation of intellectual property, and for establishing businesses.
Author: Jo Van Herwegen
Publisher: Psychology Press
ISBN: 1317563603
Category : Psychology
Languages : en
Pages : 319
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Book Description
Interest in the field of neurodevelopmental disorders has grown exponentially in recent years across a range of disciplines, including psychology, psychiatry, education and neuroscience. The research itself has become more sophisticated, using multidisciplinary methods to probe interdisciplinary questions. Neurodevelopmental Disorders: Research Challenges and Solutions provides a thorough overview of the key issues involved in researching neurodevelopmental disorders. The volume includes 14 chapters, arranged over three sections. Chapters in the first section address general research challenges for the study of neurodevelopmental disorders. The second section draws upon specific disorders (such as Williams syndrome, Autism Spectrum Disorders, Down Syndrome, Fragile X Syndrome, ADHD, and Language Disorders) to consider the syndrome-specific issues or challenges that may be crucial to advancing our understanding of aspects of cognition and behavior associated with them. The final section considers how research evidence may be translated into practice to begin making an impact upon the lives of individuals who have neurodevelopmental disorders and their families. Each chapter in the book also includes ‘practical tips’ for either conducting research with individuals who have neurodevelopmental disorders or considering wider practical issues. The book will be indispensable reading for advanced students, researchers, and practitioners in the fields of developmental psychology, developmental psychopathology, special needs education, neuropsychology, and neurodevelopmental disorders.
