Excitotoxicity in Neurological Diseases PDF Download
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Author: Carlo Ferrarese
Publisher: Springer Science & Business Media
ISBN: 9781402076800
Category : Medical
Languages : en
Pages : 378
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Book Description
The book is intended both for scientists already involved in the field, who may want a broader knowledge of all the aspects related to this complex mechanism, as well as for PhD or MD students, residents and neurologists wishing to learn more about a common mechanism involved in neuronal damage, driven by scientific curiosity or by the need to understand how new drugs, already on the market, may or may not work in various neurological disorders. With this aim, the book is basically divided into two parts, designed to be mutually integrated: - The first part covers all basic mechanisms of excitotoxicity, from glutamate metabolism, release, activity on various pre- and post-synaptic receptors, reuptake and their regulations, - The second part focuses on each neurologic disorder where this mechanism seems to play a major role, by examining in details pre-clinical and clinical evidences as well as treatment strategies in animal models and in patients. - To accomplish this complex task, world leaders in various fields, who did major contributions to define the problem and to open new avenues and are also actively working at present, agreed to put their expertise to launch the first complete and advanced level book on the role of excitotoxicity in neurologic diseases.
Author: Carlo Ferrarese
Publisher: Springer Science & Business Media
ISBN: 9781402076800
Category : Medical
Languages : en
Pages : 378
Get Book Here
Book Description
The book is intended both for scientists already involved in the field, who may want a broader knowledge of all the aspects related to this complex mechanism, as well as for PhD or MD students, residents and neurologists wishing to learn more about a common mechanism involved in neuronal damage, driven by scientific curiosity or by the need to understand how new drugs, already on the market, may or may not work in various neurological disorders. With this aim, the book is basically divided into two parts, designed to be mutually integrated: - The first part covers all basic mechanisms of excitotoxicity, from glutamate metabolism, release, activity on various pre- and post-synaptic receptors, reuptake and their regulations, - The second part focuses on each neurologic disorder where this mechanism seems to play a major role, by examining in details pre-clinical and clinical evidences as well as treatment strategies in animal models and in patients. - To accomplish this complex task, world leaders in various fields, who did major contributions to define the problem and to open new avenues and are also actively working at present, agreed to put their expertise to launch the first complete and advanced level book on the role of excitotoxicity in neurologic diseases.
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
ISBN: 0387730230
Category : Medical
Languages : en
Pages : 299
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Book Description
Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases. In addition, the authors discuss the treatment of these diseases with endogenous and exogenous antioxidants and glutamate receptor antagonists.
Author: Joseph Jankovic
Publisher: Elsevier Health Sciences
ISBN: 1437737706
Category : Medical
Languages : en
Pages : 557
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Book Description
Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com.
Author: William B. Coleman
Publisher: Academic Press
ISBN: 0128132582
Category : Medical
Languages : en
Pages : 636
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Book Description
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
Author: Anne Le
Publisher: Springer
ISBN: 331977736X
Category : Medical
Languages : en
Pages : 186
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Book Description
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author: T. Müller
Publisher: Springer Science & Business Media
ISBN: 9783211211120
Category : Medical
Languages : en
Pages : 176
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Book Description
Experts in the fields of neurology, neuroscience, neurobiology and psychiatry review and present novel findings of basic and clinical research on extrapyramidal disorders and allied conditions. New insights on the nature of extrapyramidal dysfunction and its therapy in the fields of neurology, psychiatry and neuroscience are presented.
Author: Ulrich Dirnagl
Publisher: Springer Science & Business Media
ISBN: 3662054264
Category : Medical
Languages : en
Pages : 248
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Book Description
The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Author: George Fink
Publisher: Academic Press
ISBN: 0128131470
Category : Science
Languages : en
Pages : 434
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Book Description
Stress impacts the daily lives of humans and all species on Earth.Physiology, Biochemistry, and Pathology, the third volume of the Handbook of Stress series, covers stress-related or induced physiology, biochemistry, and pathology. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the physiology of stress.A sequel to Elsevier's Encyclopedia of Stress (2000 and 2007), this Handbook of Stress series covers the many significant advances made since then and comprises self-contained volumes that each focus on a specific area within the field of stress. Targeted at scientific and clinical researchers in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, the social sciences, and stress and its management in the workplace, this volume and series are ideal for graduate students, post-doctoral fellows, and faculty interested in stress and its consequences. - Chapters offer impressive scope, with topics addressing stress-related or induced physiology, biochemistry, and pathology - Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge - Richly illustrated with explanatory figures and tables - Each chapter has a boxed "Key points call out section - The volume is fully indexed - All chapters are electronically available via ScienceDirect - Affordably priced, self-contained volume for readers specifically interested in the physiology, biochemistry and pathology of stress, avoiding the need to purchase the whole Handbook series
Author: Abel Lajtha
Publisher:
ISBN:
Category : Neurochemistry
Languages : en
Pages :
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Book Description
Author: Anthony Schapira
Publisher: John Wiley & Sons
ISBN: 0470672684
Category : Medical
Languages : en
Pages : 344
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Book Description
This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors
