Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments

Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309682630
Category : Medical
Languages : en
Pages : 85

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Book Description
As part of the overall disability determination process, the Social Security Administration uses a step-by-step approach to understand how severe an individual's condition is and whether it meets program criteria for disability. The use of various types of biomarkers has been suggested as a way to strengthen the amount and quality of objective evidence available to the review process. At the request of the Social Security Administration, the National Academies of Sciences, Engineering, and Medicine's Board on Health Care Services organized a virtual workshop on July 21, 2020, titled The State of the Science of the Use of Biomarkers to Establish the Presence and Severity of Impairments. Workshop discussions focused on the current and potential uses for biomarkers; explored legal and ethical implications associated with biomarker use in clinical decision making; and considered the possible uses of nongenetic biomarkers as tools for the diagnosis or prognosis of the severity of specific physical and mental impairments. This publication summarizes the presentations and discussion of the workshop.

Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments

Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309682630
Category : Medical
Languages : en
Pages : 85

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Book Description
As part of the overall disability determination process, the Social Security Administration uses a step-by-step approach to understand how severe an individual's condition is and whether it meets program criteria for disability. The use of various types of biomarkers has been suggested as a way to strengthen the amount and quality of objective evidence available to the review process. At the request of the Social Security Administration, the National Academies of Sciences, Engineering, and Medicine's Board on Health Care Services organized a virtual workshop on July 21, 2020, titled The State of the Science of the Use of Biomarkers to Establish the Presence and Severity of Impairments. Workshop discussions focused on the current and potential uses for biomarkers; explored legal and ethical implications associated with biomarker use in clinical decision making; and considered the possible uses of nongenetic biomarkers as tools for the diagnosis or prognosis of the severity of specific physical and mental impairments. This publication summarizes the presentations and discussion of the workshop.

Brain Injury Medicine, Third Edition

Brain Injury Medicine, Third Edition PDF Author: Nathan D. Zasler, MD
Publisher: Springer Publishing Company
ISBN: 0826143059
Category : Medical
Languages : en
Pages : 1891

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Book Description
“This updated textbook was much needed as there has been increased attention in recent years toward brain injuries. The book provides updated guidelines and clinical practice recommendations that support the intended audience of trainees and current practitioners. This update makes it the current standard text for any brain injury specialist." ---Doody's Review Service, 4 stars This revised and greatly expanded Third Edition of Brain Injury Medicine continues its reputation as the key core textbook in the field, bringing together evidence-based medicine and years of collective author clinical experience in a clear and comprehensive guide for brain injury professionals. Universally praised as the gold standard text and go-to clinical reference, the book covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomes. With 12 new chapters and expanded coverage in key areas of pathobiology and neuro-recovery, special populations, sport concussion, disorders of consciousness, neuropharmacology, and more, this "state of the science" resource promotes a multi-disciplinary approach to a complex condition with consideration of emerging topics and the latest clinical advances. Written by over 200 experts from all involved disciplines, the text runs the full gamut of practice of brain injury medicine including principles of public health and research, biomechanics and neural recovery, neuroimaging and neurodiagnostic testing, sport and military, prognosis and outcome, acute care, treatment of special populations, neurologic and other medical complications post-injury, motor and musculoskeletal problems, post-trauma pain disorders, cognitive and behavioral problems, functional mobility, neuropharmacology and alternative treatments, community reentry, and medicolegal and ethical issues. Unique in its scope of topics relevant to professionals working with patients with brain injury, this third edition offers the most complete and contemporary review of clinical practice standards in the field. Key Features: Thoroughly revised and updated Third Edition of the seminal reference on brain injury medicine Evidence-based consideration of emerging topics with new chapters covering pathobiology, biomarkers, neurorehabilitation nursing, neurodegenerative dementias, anoxic/hypoxic ischemic brain injury, infectious causes of acquired brain injury, neuropsychiatric assessment, PTSD, and capacity assessment Multi-disciplinary authorship with leading experts from a wide range of specialties including but not limited to physiatry, neurology, psychiatry, neurosurgery, neuropsychology, physical therapy, occupational therapy speech language pathology, and nursing New online chapters on survivorship, family perspectives, and resources for persons with brain injury and their caregivers Purchase includes digital access for use on most mobile devices or computers

Health-Care Utilization as a Proxy in Disability Determination

Health-Care Utilization as a Proxy in Disability Determination PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 030946921X
Category : Medical
Languages : en
Pages : 161

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Book Description
The Social Security Administration (SSA) administers two programs that provide benefits based on disability: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. This report analyzes health care utilizations as they relate to impairment severity and SSA's definition of disability. Health Care Utilization as a Proxy in Disability Determination identifies types of utilizations that might be good proxies for "listing-level" severity; that is, what represents an impairment, or combination of impairments, that are severe enough to prevent a person from doing any gainful activity, regardless of age, education, or work experience.

Psychological Testing in the Service of Disability Determination

Psychological Testing in the Service of Disability Determination PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309370930
Category : Medical
Languages : en
Pages : 246

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Book Description
The United States Social Security Administration (SSA) administers two disability programs: Social Security Disability Insurance (SSDI), for disabled individuals, and their dependent family members, who have worked and contributed to the Social Security trust funds, and Supplemental Security Income (SSSI), which is a means-tested program based on income and financial assets for adults aged 65 years or older and disabled adults and children. Both programs require that claimants have a disability and meet specific medical criteria in order to qualify for benefits. SSA establishes the presence of a medically-determined impairment in individuals with mental disorders other than intellectual disability through the use of standard diagnostic criteria, which include symptoms and signs. These impairments are established largely on reports of signs and symptoms of impairment and functional limitation. Psychological Testing in the Service of Disability Determination considers the use of psychological tests in evaluating disability claims submitted to the SSA. This report critically reviews selected psychological tests, including symptom validity tests, that could contribute to SSA disability determinations. The report discusses the possible uses of such tests and their contribution to disability determinations. Psychological Testing in the Service of Disability Determination discusses testing norms, qualifications for administration of tests, administration of tests, and reporting results. The recommendations of this report will help SSA improve the consistency and accuracy of disability determination in certain cases.

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309157277
Category : Medical
Languages : en
Pages : 335

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Book Description
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.

Monitoring Metabolic Status

Monitoring Metabolic Status PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309091594
Category : Social Science
Languages : en
Pages : 469

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Book Description
The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.

Biomarkers in Psychiatry

Biomarkers in Psychiatry PDF Author: Judith Pratt
Publisher: Springer
ISBN: 3319996428
Category : Medical
Languages : en
Pages : 437

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Book Description
This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

Biomarkers to predict, prevent and find the appropriate treatments of disorders in childhood

Biomarkers to predict, prevent and find the appropriate treatments of disorders in childhood PDF Author: Kristin Skogstrand
Publisher: Frontiers Media SA
ISBN: 2832509797
Category : Medical
Languages : en
Pages : 131

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Book Description


Evidence-Based Practice of Critical Care E-Book

Evidence-Based Practice of Critical Care E-Book PDF Author: Clifford S. Deutschman
Publisher: Elsevier Health Sciences
ISBN: 0323640699
Category : Medical
Languages : en
Pages : 688

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Book Description
Approach any critical care challenge using a practical, consistent strategy based on best practices with Evidence-Based Practice of Critical Care, 3rd Edition. Unique, question-based chapters cover the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Drs. Clifford S. Deutschman and Patrick J. Nelligan, along with nearly 200 critical-care experts, provide a comprehensive framework for translating evidence into practice, helping both residents and practitioners obtain the best possible outcomes for critically ill patients. Covers a full range of critical care challenges, from routine care to complicated and special situations. Helps you think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Features revised and updated information based on current research, and includes all-new cases on key topics and controversies such as the use/overuse of antibiotics, drug resistance in the ICU, non-invasive mechanical ventilation, frequency of transfusions, and duration of renal replacement therapies. Provides numerous quick-reference tables that summarize the available literature and recommended clinical approaches.

Immunization Safety Review

Immunization Safety Review PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309076366
Category : Medical
Languages : en
Pages : 137

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Book Description
In this report, the Immunization Safety Review committee examines the hypothesis of whether or not the use of vaccines containing the preservative thimerosal can cause neurodevelopmental disorders (NDDs), specifically autism, attention deficit/hyperactivity disorder (ADHD), and speech or language delay.