Establishing the Role of PEA3, an ETS Family Transcription Factor, During Mouse Embryonic Development PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Establishing the Role of PEA3, an ETS Family Transcription Factor, During Mouse Embryonic Development PDF full book. Access full book title Establishing the Role of PEA3, an ETS Family Transcription Factor, During Mouse Embryonic Development by . Download full books in PDF and EPUB format.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Leah Stauber
Publisher:
ISBN:
Category :
Languages : en
Pages : 106
Get Book Here
Book Description
Early embryo development is dependent on maternally derived RNA and protein synthesized during oogenesis. In the bovine embryo this dependence lasts until the 8-16 cell stage, at which time embryonic transcripts become essential for continued development. One proposed mechanism for this transition from maternal to zygotic control of development (maternal to zygotic genome activation; MZGA) is the appearance of transcription factors that activate specific genes in the embryonic genome. The E26 transforming specific (Ets) family of transcription factors is involved in development, differentiation and protease regulation, and is a logical candidate gene to be involved in MZGA. Determining the role of Ets-1 in early embryo development may provide useful insight into mechanisms contributing to early embryonic death and pregnancy failure. Ets-1 transcripts were detected in bovine primary and secondary oocytes, primary and secondary cumulus oocyte complexes (COC), presumed zygotes, and 2- to 16-cell in vitro-derived embryos. Ets-1 transcripts were also detected in Days 10 and 12 porcine in vivo-derived embryos. Blocking Ets-1 expression with antisense oligonucleotides inhibited development in in vitro-derived bovine embryos. Urokinase plasminogen activator (uPA) production by in vivo-derived bovine embryos was reduced with antisense oligonucleotides. These results suggest that Ets-1 is likely constitutively expressed in early cleavage stage bovine embryos. Although Ets-1 is probably not involved in MZGA, blocking translation of this transcript reduced bovine embryo development and protease production.
Author:
Publisher: Elsevier
ISBN: 0124116345
Category : Science
Languages : en
Pages : 415
Get Book Here
Book Description
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, including molecular-genetic imaging, imaging the tumor microenvironment, tracking cells and vaccines in vivo, and more. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students
Author:
Publisher: Elsevier
ISBN: 0080861350
Category : Medical
Languages : en
Pages : 297
Get Book Here
Book Description
This volume includes contributions from almost all of the leading neuroanatomists who have in recent years devoted their attention to the spinal cord.
Author:
Publisher: Academic Press
ISBN: 0128183527
Category : Science
Languages : en
Pages : 316
Get Book Here
Book Description
Immunobiology of Dendritic Cells Part A, Volume 348 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume presenting interesting chapters on the Origin and Development of Dendritic Cells, Dendritic Cell Subsets and Locations, Antigen Processing and Presentation, The Interaction of Dendritic Cells With Cancer Cells, The Role of Dendritic Cells in Human Diseases, and Dendritic Cells-based Vaccines for Cancer Therapy. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Cell and Molecular Biology series - Includes the latest information on the Immunobiology of Dendritic Cells, Part A
Author: Graham Dellaire
Publisher: Academic Press
ISBN: 0123972744
Category : Science
Languages : en
Pages : 511
Get Book Here
Book Description
Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. - Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. - Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.
Author: Shashikant Kulkarni
Publisher: Academic Press
ISBN: 0124051731
Category : Science
Languages : en
Pages : 489
Get Book Here
Book Description
Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing. - Simplifies complexities of NGS technologies for rapid education of clinical genomicists and genomic pathologists towards genomic medicine paradigm - Tried and tested practice-based analysis for precision diagnosis and treatment plans - Specific pipelines and meta-analysis for full range of clinically important variants
Author: Deric L. Wheeler
Publisher: Springer
ISBN: 3319118889
Category : Science
Languages : en
Pages : 888
Get Book Here
Book Description
This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.
Author: Brigid Hogan
Publisher: Cold Spring Harbor Laboratory Press
ISBN:
Category : Nature
Languages : en
Pages : 352
Get Book Here
Book Description
Of mouse development -- Setting up a colony for the production of transgenic mice -- Recovery, culture, and transfer of embryos -- Introduction of new genetic information into the developing mouse embryo -- Iolation of pluripotential stem cell lines -- Techhniques for visualizing genes and gene products -- In vitro culture of eggs, embryos, and teratocarcinoma cels -- Chemicals, supplies, and solutions.
Author: Yongwon Choi
Publisher: Springer Science & Business Media
ISBN: 038772009X
Category : Medical
Languages : en
Pages : 164
Get Book Here
Book Description
A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative Role Of Ids In Osteoclastogenesis.- Functional Genetic and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic Regulation Of Bone Development.- Pth Regulates The Hematopoietic Stem Cell Niche In Bone.- Regulation Of Hematopoietic Stem Cells In The Osteoblastic Niche.- The Chemokine Cxcl12 And Regulation Of Hsc And Lymphocyte Development In The Bone Marrow Niche.- Osteoclast Precursor Cells.- Interaction with estrogen receptors as treatment of arthritis and osteoporosis.- Novel Signaling Pathways And Therapeutic Targets In Osteoclasts.- The Enigmatic Function of TREM-2 in Osteoclastogenesis.- Role of cell-matrix interactions in osteoclast differentiation.- Positive and negative roles of IL-6, STAT3 and SOCS3 in inflammatory arthritis.- Control of Osteoclast activity and bone loss by IKK subunits: new targets for therapy.- Targeting Osteoporosis And Rheumatoid Arthritis By Active Vaccination Against Rankl.- RANKL Inhibition: From Mice to Men (and Women).
