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Author: Anuradha Mudipalli
Publisher: Springer
ISBN: 3319554484
Category : Medical
Languages : en
Pages : 235
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Book Description
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Author: Anuradha Mudipalli
Publisher: Springer
ISBN: 3319554484
Category : Medical
Languages : en
Pages : 235
Get Book Here
Book Description
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Author:
Publisher: Academic Press
ISBN: 9780123786364
Category : Technology & Engineering
Languages : en
Pages : 520
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Book Description
Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. The companion volume, Homeostasis and Toxicology of Non-Essential Metals, Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers. All major essential metals of interest are covered in metal-specific chapters Each metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metal A common format is featured throughout this two volume edition
Author: Robert R Crichton
Publisher: Royal Society of Chemistry
ISBN: 1782623892
Category : Science
Languages : en
Pages : 336
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Book Description
Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.
Author:
Publisher: Springer Science & Business Media
ISBN: 3642698727
Category : Science
Languages : en
Pages : 209
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Book Description
Scientific progress, more and more, makes it possible to relate disease to irreg ularities on a molecular basis. Both, diagnosis and cure can be targeted to a well defined biological structure. Modern medical research aims at the investigation of the interaction of molecules and bio-macro-molecules, formerly the area of chemis try, biochemistry and pharmacology. This series was founded to provide a vehicle for the dissemination of results in a multidisciplinary area of contemporary research. It will publish extensive review articles at a high level, that will relate a particular subject to the scopes of medical chemistry. Thus, information and useful references will be spread among the schol ars. Table of Contents Toxicity and Carcinogenicity of Essential and Non-essential Metals M. Costa, A. J. Kraker and S. R. Patierno (USA) .......... 1 Secondary Metabolites with Antibiotic Activity from the Primary Metabolism of Aromatic Amino Acids R. G. Werner (FRG) . . . . . . . . . . . . . . . . . . . . . .. . . 47 . . . . Clinical Pharmacology of Benzodiazepines U. Klotz (FRG) .............. .
Author: Wolfgang Maret
Publisher: Royal Society of Chemistry
ISBN: 1782622829
Category : Science
Languages : en
Pages : 990
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Book Description
Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.
Author: Nichole Coleman, PhD
Publisher: Lulu.com
ISBN: 1483469085
Category : Science
Languages : en
Pages : 198
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Book Description
No matter how careful we are at using metals in industrial processes, some level of human exposure is unavoidable. Countless metals are obtained through mining and smelting activities that amplify their distribution throughout the environment. Applications of metals in industry, medicine, and agriculture have increased our exposure. These metals are not merely an occupational hazard for those working with them-they affect consumers and anyone exposed through environmental contamination. Even worse, they cannot be destroyed and are thus non-biodegradable. The blades we use, the pots and pans we cook with, children's face paint, and facial makeup contain toxic metals. Toxic heavy metals are also found in cigarettes, gourmet foods such as seasonings, fish, and chocolates. When you sprinkle a dish with Himalayan sea salt, you may end up ingesting toxic metals such as arsenic, cadmium and lead.
Author:
Publisher:
ISBN:
Category : Zinc
Languages : en
Pages : 354
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Book Description
The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. Profiles are updated on a periodic basis and released for a public comment period. For more information visit ATSDR.
Author: I. J. T. Davies
Publisher: Butterworth-Heinemann
ISBN: 1483192830
Category : Science
Languages : en
Pages : 139
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Book Description
The Clinical Significance of the Essential Biological Metals covers the six trace minerals necessary for human survival,namely zinc, copper, manganese, molybdenum, chromium, and cobalt. This book contains seven chapters that specifically discuss the effects of these minerals for enzyme function, protein synthesis, and their nutritional significance in veterinary and agricultural practice. Some of the topics covered in the book are the importance of interactions between the essential biological metals; importance of fertilizers; analysis of water supply, soil mineral content, and cancer mortality; influence of drinking water on atherosclerosis; non-essential but biologically important metals; and absorption and availability of zinc. Other chapters deal with the factors influencing absorption of zinc, the effects of copper on zinc availability, and the form and absorption of copper in the diet. A chapter is devoted to the role of lymphatics in copper absorption. Another chapter focuses on the distribution, absorption, and transport of manganese in the blood. The book can provide useful information to doctors, biochemists, nutritionists, students, and researchers.
Author: Deborah Zamble
Publisher: Royal Society of Chemistry
ISBN: 1788010582
Category : Science
Languages : en
Pages : 396
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Book Description
Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.
Author: Chris M. Wood
Publisher: Academic Press
ISBN: 0123786347
Category : Electronic books
Languages : en
Pages : 531
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Book Description
Homeostasis and Toxicology of Non-Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Ag, Al, Cd, Pb, Hg, As, Sr, and U have no known nutritive function in fish at present, but are toxic at fairly low levels.
