Endocrine Disruptor Impact on Zebrafish Larvae PDF Download
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Author: Ahmed Nasri
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 0
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Book Description
Endocrine-disrupting chemicals (EDCs), including polychlorinated biphenyls (PCBs), bisphenol A (BPA), pharmaceutical drugs, and pesticides, affect a variety of hormone-regulated physiological pathways in humans and wildlife. The occurrence of these EDCs in the aquatic environment is linked with vertebrates,Äô health alteration. EDCs exhibit lipophilic characteristics and bind to hydrophobic areas of steroid receptors, such as the estrogen receptor, which are involved in vertebrate developmental regulation. Mainly, EDCs modify the transcription of several genes involved in individual homeostasis. Zebrafish conserve many developmental pathways found in humans, which makes it an appreciated model system for EDCs research studies, especially on early organ development. In the current chapter, we emphasize on latest published papers of EDCs effects on lateral line regeneration in zebrafish larvae. Similarly, we describe other special impacts of EDCs exposure. In conclusion, we make the case that the zebrafish lateral line exposed to EDCs can provide important insights into human health.
Author: Ahmed Nasri
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 0
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Book Description
Endocrine-disrupting chemicals (EDCs), including polychlorinated biphenyls (PCBs), bisphenol A (BPA), pharmaceutical drugs, and pesticides, affect a variety of hormone-regulated physiological pathways in humans and wildlife. The occurrence of these EDCs in the aquatic environment is linked with vertebrates,Äô health alteration. EDCs exhibit lipophilic characteristics and bind to hydrophobic areas of steroid receptors, such as the estrogen receptor, which are involved in vertebrate developmental regulation. Mainly, EDCs modify the transcription of several genes involved in individual homeostasis. Zebrafish conserve many developmental pathways found in humans, which makes it an appreciated model system for EDCs research studies, especially on early organ development. In the current chapter, we emphasize on latest published papers of EDCs effects on lateral line regeneration in zebrafish larvae. Similarly, we describe other special impacts of EDCs exposure. In conclusion, we make the case that the zebrafish lateral line exposed to EDCs can provide important insights into human health.
Author: Gitte I. Petersen
Publisher: Nordic Council of Ministers
ISBN: 9789289307215
Category : Endocrine disrupting chemicals
Languages : en
Pages : 70
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Book Description
Author: Allan V. Kalueff
Publisher: Humana Press
ISBN: 9781617795961
Category : Medical
Languages : en
Pages : 0
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Book Description
Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. That, along with their low cost, easy manipulation, short reproductive cycles, and physiological homology to humans, has made zebrafish a vital model organism for neuroscience research. Zebrafish Protocols for Neurobehavioral Research addresses protocols for both larval and adult models, written by the leading experts in the field of zebrafish research. Part I of this book takes advantage of the high-throughput nature of larval models to offer protocols for research requiring high output, easily manipulated screens. The second half of the book focuses on the robust and sophisticated behaviors of adult zebrafish, suitable for the neurophenotyping of complex traits and multi-domain disorders. Importantly, these models complement each other, working together to provide researchers with valuable insights into neurobiology of normal and pathological behavior. Thorough and cutting-edge, this volume is a useful, authoritative reference guide that should hold a coveted spot in zebrafish laboratories across the globe.
Author:
Publisher: Nordic Council of Ministers
ISBN: 9789289304801
Category : Zebra danio
Languages : en
Pages : 72
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Book Description
Author: Ling Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Development problems induced by endocrine disruptors (EDCs) are currently understudied. However, early exposure to EDCs may lead to deleterious and permanent problems in later lifetime. Zebrafish (Danio rerio) transgenic lines with tissue-specific expression of GFP are useful tools to identify the organs affected by a given compound. We have used 7 transgenic lines to visualize in vivo whether 6 known EDCs and 3 other pharmaceuticals can alter organogenesis during development of zebrafish. This screen revealed that 4 chemicals have effects on 4 different organs. The EDC tetrabromobisphenol-A, as well as the tested medicines (diclofenac, trichostatin A and valproic acid) disrupt vascular system development in zebrafish embryo. Moreover, HDAC inhibitors trichostatin A and valproic acid inhibit both endocrine and exocrine pancreas development. Developmental delays were also induced by trichostatin A and valproic acid in the liver and in the pharyngeal teeth. Traditional Chinese medicines (TCMs) are important components of modern medicine. However we know little about the biological activities of TCMs compounds during development. We used zebrafish embryos to study the effects of 3 plants and 5 of their major compounds on the development. We observed that zebrafish embryogenesis was delayed by water extracts from Astragalus membranaceus and Akebia quinata. We also found that the vascular development was affected at different levels by Salvia miltiorrhiza water extracts and by its 3 major components either used alone or mixed together.Our results show that EDCs and TCMs can cause problems during zebrafish embryogenesis. They also show that zebrafish is a powerful tool for rapid in vivo screening of small molecules and their effects on development. This work also enables us to draw a parallel between EDC and some TCMS, which may act on similar targets, such as nuclear receptors.
Author: Lisa Baumann
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264264477
Category :
Languages : en
Pages : 24
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Book Description
This Test Guideline is designed to be used for assessing the effects of chemicals on the reproductive output of the enchytraeid worm, Enchytraeus albidus Henle 1873, in soil.
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 1439830096
Category : Medical
Languages : en
Pages : 312
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Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Author: Guy Van Vliet
Publisher: Karger Medical and Scientific Publishers
ISBN: 380558296X
Category : Medical
Languages : en
Pages : 203
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Book Description
As is the case in all fields of medicine, developmental endocrinology is now being studied at the molecular level. In this volume world-class researchers review the advances of the past decade in the study of normal and abnormal organogenesis of the thyroid gland and of the ontogeny of its function. They describe human thyroid development and its defects with the help of genetic studies in mouse models. Genetic defects of thyroid hormone synthesis are covered and their clinical relevance debated. The important field of thyroid cancer in the context of spontaneous occurrence and as part of familial neoplasia syndromes is described in detail. Finally, the important problem of environmental iodine deficiency which has emerged as a global public health concern is addressed. For the first time, a decade of work is presented in a concise and highly readable form. Offering valuable insight both for senior clinicians and graduate students, this publication will be of central interest to basic scientists involved in developmental biology as well as to pediatricians and endocrinologists dealing with patients with congenital disorders of thyroid function.
Author: Gregory Daniel Ballard
Publisher:
ISBN:
Category : Endocrine disrupting chemicals
Languages : en
Pages : 156
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Book Description
