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Author: David Pines
Publisher: CRC Press
ISBN: 0429961146
Category : Science
Languages : en
Pages : 250
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Book Description
Evolution of self-replicating macromolecules through natural selection is a dynamically ordered process. Two concepts are introduced to describe the physical regularity of macromolecular evolution: sequence space and quasi-species. Natural selection means localization of a mutant distribution in sequence space. This localized distribution, called the quasi-species, is centered around a master sequence (or a degenerate set), that the biologist would call the wild-type. The self-ordering of such a system is an essential consequence of its formation through self-reproduction of its macromolecular consti tuents, a process that in the dynamical equations expresses itself by positive diagonal coefficients called selective values. The theory describes how population numbers of wild type and mutants are related to the distribution of selective values, that is to say, how value topography maps into population topography. For selectively (nearly) neutral mutants appearing in the quasi- species distribution, population numbers are greatly enhanced as compared to those of disadvantageous mutants, even more so in continuous domains of such selectively valuable mutants. As a consequence, mutants far distant from the wild type may occur because they are produced with the help of highly populated, less distant precursors. Since values are cohesively distributed, like mountains on earth, and since their positions are multiply connected in the high-dimensional sequence space, the overpopulation of (nearly) neural mutants provides guidance for the evolutionary process. Localization in sequence space, subject to a threshold in the fidelity of reproduction, is steadily challenged until an optimal state is reached. The model has been designed according to experimentally determined properties of self-replicating molecules. The conclusions reached from the theoretical models can be used to construct machines that provide optimal conditions for the evolution of functional macromolecules.
Author: David Pines
Publisher: CRC Press
ISBN: 0429961146
Category : Science
Languages : en
Pages : 250
Get Book Here
Book Description
Evolution of self-replicating macromolecules through natural selection is a dynamically ordered process. Two concepts are introduced to describe the physical regularity of macromolecular evolution: sequence space and quasi-species. Natural selection means localization of a mutant distribution in sequence space. This localized distribution, called the quasi-species, is centered around a master sequence (or a degenerate set), that the biologist would call the wild-type. The self-ordering of such a system is an essential consequence of its formation through self-reproduction of its macromolecular consti tuents, a process that in the dynamical equations expresses itself by positive diagonal coefficients called selective values. The theory describes how population numbers of wild type and mutants are related to the distribution of selective values, that is to say, how value topography maps into population topography. For selectively (nearly) neutral mutants appearing in the quasi- species distribution, population numbers are greatly enhanced as compared to those of disadvantageous mutants, even more so in continuous domains of such selectively valuable mutants. As a consequence, mutants far distant from the wild type may occur because they are produced with the help of highly populated, less distant precursors. Since values are cohesively distributed, like mountains on earth, and since their positions are multiply connected in the high-dimensional sequence space, the overpopulation of (nearly) neural mutants provides guidance for the evolutionary process. Localization in sequence space, subject to a threshold in the fidelity of reproduction, is steadily challenged until an optimal state is reached. The model has been designed according to experimentally determined properties of self-replicating molecules. The conclusions reached from the theoretical models can be used to construct machines that provide optimal conditions for the evolution of functional macromolecules.
Author: M. Mitchell Waldrop
Publisher: Open Road Media
ISBN: 150405914X
Category : Science
Languages : en
Pages : 492
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Book Description
“If you liked Chaos, you’ll love Complexity. Waldrop creates the most exciting intellectual adventure story of the year” (The Washington Post). In a rarified world of scientific research, a revolution has been brewing. Its activists are not anarchists, but rather Nobel Laureates in physics and economics and pony-tailed graduates, mathematicians, and computer scientists from all over the world. They have formed an iconoclastic think-tank and their radical idea is to create a new science: complexity. They want to know how a primordial soup of simple molecules managed to turn itself into the first living cell—and what the origin of life some four billion years ago can tell us about the process of technological innovation today. This book is their story—the story of how they have tried to forge what they like to call the science of the twenty-first century. “Lucidly shows physicists, biologists, computer scientists and economists swapping metaphors and reveling in the sense that epochal discoveries are just around the corner . . . [Waldrop] has a special talent for relaying the exhilaration of moments of intellectual insight.” —The New York Times Book Review “Where I enjoyed the book was when it dove into the actual question of complexity, talking about complex systems in economics, biology, genetics, computer modeling, and so on. Snippets of rare beauty here and there almost took your breath away.” —Medium “[Waldrop] provides a good grounding of what may indeed be the first flowering of a new science.” —Publishers Weekly
Author: David Pines
Publisher: Addison Wesley Publishing Company
ISBN: 9780201316018
Category :
Languages : en
Pages : 384
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Book Description
Author: Baker Brownell
Publisher:
ISBN:
Category : Cosmology
Languages : en
Pages : 484
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Book Description
Author: Ruren Xu
Publisher: Elsevier
ISBN: 0444535993
Category : Science
Languages : en
Pages : 612
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Book Description
The contributors to this book discuss inorganic synthesis reactions, dealing with inorganic synthesis and preparative chemistry under specific conditions. They go on to describe the synthesis, preparation and assembly of six important categories of compounds with wide coverage of distinct synthetic chemistry systems
Author: Larry Rockwood
Publisher: Oxford University Press
ISBN: 0198042264
Category : Science
Languages : en
Pages : 477
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Book Description
This book reviews and analyzes the period (roughly from the 1950s to the present) when the "environment" became an issue as important as economic growth, or war and peace; to assess the current situation, and begin planning for the challenges that lie ahead. Most people are aware of both the environmental destruction taking place around the world and of the specter of climate change. The devastation of New Orleans by hurricane Katrina illustrates the potential for disaster when climate change is combined with the mismanaged environmental policy. How did we get to this point? What has been done and what can be done to avoid future environmental disasters? Thirty-two contributing chapter authors (among them, one of the principal drafters of the National Environmental Policy Act, Chief of the African Environment Division and the World Bank, Vice President of the Center for Conservation Innovation at the World Wildlife Fund, President of the Zoological Society of London, former President of the Ecological Society of America) use their unique, authoritative perspective to review the evolution of environmental science and policy in the past half century. Each author describes the evolution of environmental science and policy in the past half century and consider the challenges of the future. Although the authors of this book come from various fields, they have followed paths that have generally converged on the concept of sustainability. This book attempts to define what sustainability is, how we can achieve it, and what the prospects for sustainability in the future are.
Author: Philip W. Anderson
Publisher: CRC Press
ISBN: 0429972474
Category : Mathematics
Languages : en
Pages : 232
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Book Description
This book proceeds from a meeting at the Santa Fe Institute where economists and physical and biological scientists came together to discuss a conceptual framework incorporating a more appropriate mathematics with a greatly strengthened capacity to deal simultaneously with multiple variables, nonlinearity, incomplete information and dynamical processes.
Author: Sayan Ganguly
Publisher: CRC Press
ISBN: 1040094384
Category : Technology & Engineering
Languages : en
Pages : 375
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Book Description
Magnetic composite particles offer much potential for use in a variety of applications, including manufacturing, environmental protection, microfluidics, microelectronics, and biomedicine. Magnetic Polymer Composites and Their Emerging Applications explores leading research on the fabrication, characterization, properties, and all reported applications of magnetic polymer composites. Features: Discusses synthesis, properties, and modern fabrication technologies of magnetic polymer composites Describes the biocompatibility, suitability, and toxic effects of these materials Covers a variety of applications including those in biomedicine, wastewater treatment, soft robotics, 3D/4D printing, and agriculture Details opportunities and future directions in magnetic polymer composites and their surface decorations This unique book serves as a road map for materials engineers, as well as researchers, academics, technologists, and students working in sensor technology.
Author: P.H. Seeberger
Publisher: Springer Science & Business Media
ISBN: 3540708499
Category : Science
Languages : en
Pages : 247
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Book Description
In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged. This book offers a compact overview of the current status of these technologies and includes many real-life examples from industry and academic institutions.
Author: EuroScicon
Publisher: EuroScicon
ISBN:
Category : Technology & Engineering
Languages : en
Pages : 90
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Book Description
April 26-27, 2018 Rome, Italy Key Topics : Nano Electronics, Nanotechnology For Clean Energy And Environment, Nano Applications, Nano Biotechnology, Nano Bio Medicine, Carbon And Graphene Nano-Structures, Polymer Science Engineering, Bio Polymers And Bio Plastics, Advanced Materials Science, Nano Composites, Nano Technology In Materials Science, Corrosion Engineering And Corrosion Protection, Biomaterials, Electronic, Optical & Magnetic Materials., Nano Photonics, Advanced Nano Materials,
