Elaboration d'une batterie de tests pour contribuer au diagnostic précoce de la maladie d'Alzheimer

Elaboration d'une batterie de tests pour contribuer au diagnostic précoce de la maladie d'Alzheimer PDF Author: Christelle Rieux
Publisher:
ISBN:
Category :
Languages : fr
Pages : 272

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Book Description
La maladie d’Alzheimer est principalement décrite comme présentant des troubles de la mémoire épisodique, avec une altération plus tardive des fonctions cognitives. Notre étude se voulait donc la démonstration de la place prépondérante des troubles du langage dès la phase « prodromale » de la maladie. Pour cela nous avons souhaité observer le langage sous plusieurs de ses facettes. C’est pourquoi nous avons réuni cinq tests afin de créer une batterie pouvant participer au diagnostic précoce de la MA. Nous avons donc fait passer une épreuve de fluence sémantique et lexicale, une épreuve d’appariement des synonymes, une épreuve de langage écrit (sous forme de dictée), une épreuve de compréhension et une épreuve de dénomination à 30 sujets sains ainsi qu’à neuf patients atteints de la maladie d’Alzheimer. Nous voulions donc étudier l’efficacité de cet assemblage de test, ainsi que la pertinence des différents domaines langagiers étudiés à un stade précoce. Les mémoires réalisés précédemment sur l’élaboration de certaines de ces épreuves démontraient déjà l’intérêt de l’étude de ces aspects dans la maladie d’Alzheimer. Notre étude reste dans la continuité de ces observations, en pointant également la sensibilité des épreuves de fluence et de dénomination. Le faible nombre de patients réunis ne nous a cependant pas permis de réaliser une étude statistique et de dégager une norme à notre batterie de tests. Toutefois, même si nous n’avons pu prouver l’efficacité de notre batterie, une analyse des différents tests auprès de notre population témoin nous a permis d’apporter des modifications au test de langage écrit et de compréhension qui nous paraissaient pertinentes. Notre étude peut ouvrir la voie à la réalisation d’autres épreuves sensibles aux troubles précoces de la maladie d’Alzheimer, ainsi qu’à la création d’une batterie de test plus complète et finalisée.

Elaboration d'une batterie de tests pour contribuer au diagnostic précoce de la maladie d'Alzheimer

Elaboration d'une batterie de tests pour contribuer au diagnostic précoce de la maladie d'Alzheimer PDF Author: Christelle Rieux
Publisher:
ISBN:
Category :
Languages : fr
Pages : 272

Get Book Here

Book Description
La maladie d’Alzheimer est principalement décrite comme présentant des troubles de la mémoire épisodique, avec une altération plus tardive des fonctions cognitives. Notre étude se voulait donc la démonstration de la place prépondérante des troubles du langage dès la phase « prodromale » de la maladie. Pour cela nous avons souhaité observer le langage sous plusieurs de ses facettes. C’est pourquoi nous avons réuni cinq tests afin de créer une batterie pouvant participer au diagnostic précoce de la MA. Nous avons donc fait passer une épreuve de fluence sémantique et lexicale, une épreuve d’appariement des synonymes, une épreuve de langage écrit (sous forme de dictée), une épreuve de compréhension et une épreuve de dénomination à 30 sujets sains ainsi qu’à neuf patients atteints de la maladie d’Alzheimer. Nous voulions donc étudier l’efficacité de cet assemblage de test, ainsi que la pertinence des différents domaines langagiers étudiés à un stade précoce. Les mémoires réalisés précédemment sur l’élaboration de certaines de ces épreuves démontraient déjà l’intérêt de l’étude de ces aspects dans la maladie d’Alzheimer. Notre étude reste dans la continuité de ces observations, en pointant également la sensibilité des épreuves de fluence et de dénomination. Le faible nombre de patients réunis ne nous a cependant pas permis de réaliser une étude statistique et de dégager une norme à notre batterie de tests. Toutefois, même si nous n’avons pu prouver l’efficacité de notre batterie, une analyse des différents tests auprès de notre population témoin nous a permis d’apporter des modifications au test de langage écrit et de compréhension qui nous paraissaient pertinentes. Notre étude peut ouvrir la voie à la réalisation d’autres épreuves sensibles aux troubles précoces de la maladie d’Alzheimer, ainsi qu’à la création d’une batterie de test plus complète et finalisée.

The Patient Will See You Now

The Patient Will See You Now PDF Author: Eric Topol
Publisher: Basic Books
ISBN: 0465094473
Category : Medical
Languages : en
Pages : 386

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Book Description
The essential guide by one of America's leading doctors to how digital technology enables all of us to take charge of our health A trip to the doctor is almost a guarantee of misery. You'll make an appointment months in advance. You'll probably wait for several hours until you hear "the doctor will see you now"-but only for fifteen minutes! Then you'll wait even longer for lab tests, the results of which you'll likely never see, unless they indicate further (and more invasive) tests, most of which will probably prove unnecessary (much like physicals themselves). And your bill will be astronomical. In The Patient Will See You Now, Eric Topol, one of the nation's top physicians, shows why medicine does not have to be that way. Instead, you could use your smartphone to get rapid test results from one drop of blood, monitor your vital signs both day and night, and use an artificially intelligent algorithm to receive a diagnosis without having to see a doctor, all at a small fraction of the cost imposed by our modern healthcare system. The change is powered by what Topol calls medicine's "Gutenberg moment." Much as the printing press took learning out of the hands of a priestly class, the mobile internet is doing the same for medicine, giving us unprecedented control over our healthcare. With smartphones in hand, we are no longer beholden to an impersonal and paternalistic system in which "doctor knows best." Medicine has been digitized, Topol argues; now it will be democratized. Computers will replace physicians for many diagnostic tasks, citizen science will give rise to citizen medicine, and enormous data sets will give us new means to attack conditions that have long been incurable. Massive, open, online medicine, where diagnostics are done by Facebook-like comparisons of medical profiles, will enable real-time, real-world research on massive populations. There's no doubt the path forward will be complicated: the medical establishment will resist these changes, and digitized medicine inevitably raises serious issues surrounding privacy. Nevertheless, the result-better, cheaper, and more human health care-will be worth it. Provocative and engrossing, The Patient Will See You Now is essential reading for anyone who thinks they deserve better health care. That is, for all of us.

Thickening Fat

Thickening Fat PDF Author: May Friedman
Publisher: Routledge
ISBN: 0429017634
Category : Social Science
Languages : en
Pages : 360

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Book Description
Thickening Fat: Fat Bodies, Intersectionality, and Social Justice seeks to explore the multiple, variable, and embodied experiences of fat oppression and fat activisms. Moving beyond an analysis of fat oppression as singular, this book will aim to unpack the volatility of fat—the mutability of fat embodiments as they correlate with other embodied subjectivities, and the threshold where fat begins to be reviled, celebrated, or amended. In addition, Thickening Fat explores the full range of intersectional and liminal analyses that push beyond the simple addition of two or more subjectivities, looking instead at the complex alchemy of layered and unstable markers of difference and privilege. Cognizant that the concept of intersectionality has been filled out in a plurality of ways, Thickening Fat poses critical questions around how to render analysis of fatness intersectional and to thicken up intersectionality, where intersectionality is attenuated to the shifting and composite and material dimensions to identity, rather than reduced to an “add difference and stir” approach. The chapters in this collection ask what happens when we operationalize intersectionality in fat scholarship and politics, and we position difference at the centre and start of inquiry.

Input and Interaction in Language Acquisition

Input and Interaction in Language Acquisition PDF Author: Clare Gallaway
Publisher: Cambridge University Press
ISBN: 9780521437257
Category : Language Arts & Disciplines
Languages : en
Pages : 340

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Book Description
Language addressed to children, or 'Baby Talk', became the subject of research interest thirty years ago. Since then, the linguistic environment of infants and toddlers has been widely studied. Input and Interaction in Language Acquisition is an up-to-date statement of the facts and controversies surrounding 'Baby Talk', its nature and likely effects. With contributions from leading linguists and psychologists, it explores language acquisition in different cultures and family contexts, in typical and atypical learners, and in second and foreign language learners. It is designed as a sequel to the now famous Talking to Children, edited by Catherine Snow and Charles Ferguson, and Professor Snow here provides an introduction, comparing issues of importance in the field today with the previous concerns of researchers.

Language Intervention Strategies in Adult Aphasia

Language Intervention Strategies in Adult Aphasia PDF Author: Roberta Chapey
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 1224

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Book Description
This newly revised and updated Fourth Edition continues to focus on speech therapy, addressing concerns that aid in the rehabilitation and recovery of aphasia patients. Topics include: assessment of language and communication, principles of language intervention, restorative approaches to language intervention, cognitive neuropsychological approach implications, functional intervention, and treatment for each syndrome. Other approaches and therapy for associated neuropathologies of speech and language related functions are also discussed. For more information, visit http: //connection.LWW.com/go/chapey.

Neuropsycholinguistic Perspectives on Language Cognition

Neuropsycholinguistic Perspectives on Language Cognition PDF Author: Corine Astesano
Publisher: Psychology Press
ISBN: 1135099472
Category : Language Arts & Disciplines
Languages : en
Pages : 227

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Book Description
This book brings together experts from the fields of linguistics, psychology and neuroscience to explore how a multidisciplinary approach can impact on research into the neurocognition of language. International contributors present cutting-edge research from cognitive and developmental psychology, neuropsychology, psycholinguistics and computer science, and discuss how this contributes to neuropsycholinguistics, a term coined by Jean-Luc Nespoulous, to whom this book is dedicated. Chapters illustrate how researchers with different methods and theoretical backgrounds can contribute to a unified vision of the study of language cognition. Reinterpreting neuropsycholinguistics through the lens of each research field, the book demonstrates important attempts to adopt a comprehensive view of speech and language pathology. Divided into three sections the book covers: linguistic mechanisms and the architecture of language the relationship between language and other cognitive processes the assessment of speech and language disabilities and compensatory mechanisms. Neuropsycholinguistic Perspectives on Language Cognition presents a unique contribution to cognitive science and language science, from linguistics to neuroscience. It will interest academics and scholars in the field, as well as medical researchers, psychologists, and speech and language therapists.

Handbook of the Neuroscience of Language

Handbook of the Neuroscience of Language PDF Author: Brigitte Stemmer
Publisher: Academic Press
ISBN: 0080564917
Category : Language Arts & Disciplines
Languages : en
Pages : 505

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Book Description
In the last ten years the neuroscience of language has matured as a field. Ten years ago, neuroimaging was just being explored for neurolinguistic questions, whereas today it constitutes a routine component. At the same time there have been significant developments in linguistic and psychological theory that speak to the neuroscience of language. This book consolidates those advances into a single reference. The Handbook of the Neuroscience of Language provides a comprehensive overview of this field. Divided into five sections, section one discusses methods and techniques including clinical assessment approaches, methods of mapping the human brain, and a theoretical framework for interpreting the multiple levels of neural organization that contribute to language comprehension. Section two discusses the impact imaging techniques (PET, fMRI, ERPs, electrical stimulation of language cortex, TMS) have made to language research. Section three discusses experimental approaches to the field, including disorders at different language levels in reading as well as writing and number processing. Additionally, chapters here present computational models, discuss the role of mirror systems for language, and cover brain lateralization with respect to language. Part four focuses on language in special populations, in various disease processes, and in developmental disorders. The book ends with a listing of resources in the neuroscience of language and a glossary of items and concepts to help the novice become acquainted with the field. Editors Stemmer & Whitaker prepared this book to reflect recent developments in neurolinguistics, moving the book squarely into the cognitive neuroscience of language and capturing the developments in the field over the past 7 years. - History section focuses on topics that play a current role in neurolinguistics research, aphasia syndromes, and lesion analysis - Includes section on neuroimaging to reflect the dramatic changes in methodology over the past decade - Experimental and clinical section reflects recent developments in the field

Magnetic Nanoparticles in Human Health and Medicine

Magnetic Nanoparticles in Human Health and Medicine PDF Author: Costica Caizer
Publisher: John Wiley & Sons
ISBN: 1119754747
Category : Science
Languages : en
Pages : 512

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Book Description
Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

The Explicitation Interview

The Explicitation Interview PDF Author: Pierre Vermersch
Publisher: Explicitation Interview
ISBN: 9781090169259
Category : Study Aids
Languages : en
Pages : 170

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Book Description
This book was first published in French in 1994. It has been a training support to numerous researchers as well as practitioners, such as teachers, health workers, personal or sport trainers. Since then, it has constantly been republished and a glossary has been added in 1998. This version is the first complete edition of the book in English. The main idea of this new interview technique is to help a teacher, a supervisor or a researcher to guide the student, the practitioner or the subject to give a fine retrospective description of an action. As it is only the subject that has access to this mental or physical action, the goal is to help the subject with the verbalization, putting the implicit knowledge of this action in words. Yet, to achieve this verbalization, we need guidance, because we don't know how to give such a description ourselves. If we leave the interviewee without guidance, he risks remaining in the implicit, speaking in a general way, or in an incomplete or imprecise way, commenting instead of describing. The explicit and precise description we aim is the opposite of the implicit, meaning a fine, detailed and complete way of putting the action in words. The final aim is to elucidate what the subject did to seek his goal

Cognitive Neuropsychology and Neurolinguistics

Cognitive Neuropsychology and Neurolinguistics PDF Author: Alfonso Caramazza
Publisher: Psychology Press
ISBN:
Category : Language Arts & Disciplines
Languages : en
Pages : 320

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Book Description
These papers emphasize the development of detailed models of normal cognitive functioning through the analysis of cognitive impairment. They differ, however, in terms of the cognitive domain investigated and the dominant methodology of the reported research. Areas examined include imagery, attention, memory, and language. A substantial portion of the papers presented address language processing because research on language disorders has been a major focus of interest in cognitive neuropsychological research.