Efforts Toward the Gram Scale Synthesis of Spongistatin 1 PDF Download
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Author: Rebecca A. Arvary
Publisher:
ISBN:
Category :
Languages : en
Pages : 84
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Book Description
Author: Rebecca A. Arvary
Publisher:
ISBN:
Category :
Languages : en
Pages : 84
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Book Description
Author: Wenyu Zhu
Publisher:
ISBN:
Category :
Languages : en
Pages : 452
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Book Description
Author: Chris Sfouggatakis
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 840
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Book Description
Author: Mario Waser
Publisher: Springer Science & Business Media
ISBN: 3709111633
Category : Science
Languages : en
Pages : 205
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Book Description
This book provides the reader with an illustrative overview concerning successful and widely used applications of organocatalysis in the field of natural product synthesis. The main focus will be on organocatalytic key-steps for each (multi-step) synthesis described, whereas other often particularly innovative transformations will be omitted, as this would be beyond the scope of this volume.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1834
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Work on the synthesis of an analog of spongistatin 1, specifically on the completion of the northern ABCD hemisphere, will also be discussed.
Author: Mark Wild
Publisher:
ISBN:
Category :
Languages : en
Pages : 374
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Book Description
Author: David Glenn Washburn
Publisher:
ISBN:
Category : Marine pharmacology
Languages : en
Pages : 316
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Book Description
Author: Joshua Ross Infantine
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
A major goal of the Leighton group is the synthesis of biologically relevant polyketide natural products. Among the most potent and chemically intriguing member of this class is spongistatin 1. This molecule has interested biologists and chemists for more than two decades. In this thesis, we report a highly practical and efficient synthesis of the EF fragment of spongistatin 1. This relied on the rapid introduction of a complex stereochemical array using double cross-metathesis/Sharpless asymmetric dihydroxylation reactions to quickly build the F-ring of spongistatin. The six contiguous stereocenters of the F-ring were established in just five steps. A new one-pot asymmetric strained-silane mediated allylation was developed that was greatly improved over previous methods in regards to practicality and substrate scope. This methodology was used to introduce the sensitive chlorodiene side chain. Finally, completion of the EF fragment led to the synthesis of a spongistatin 1 analog, using our previously developed redesigned ABCD fragment.
