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Author:
Publisher:
ISBN:
Category : Chemotherapy
Languages : en
Pages : 2278
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Book Description
Comprehensive drug information reference source intended for health professionals. Arranged by therapeutic drug classes. Each entry (monograph) gives detailed information covering such topics as actions, adverse reactions, and overdosage. General index
Author:
Publisher:
ISBN:
Category : Chemotherapy
Languages : en
Pages : 2278
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Book Description
Comprehensive drug information reference source intended for health professionals. Arranged by therapeutic drug classes. Each entry (monograph) gives detailed information covering such topics as actions, adverse reactions, and overdosage. General index
Author: Graziano Pinna
Publisher:
ISBN: 9781634820769
Category :
Languages : en
Pages : 412
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Book Description
Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.
Author: Daphne A. Roe
Publisher: Springer Science & Business Media
ISBN: 9401160473
Category : Science
Languages : en
Pages : 227
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Book Description
When we learn from a patient, clinician, or medical record that a drug has been discontinued, it is logical to ask why. The drug may no longer be needed; it may not have produced the desired effect; it may have produced an adverse reaction; a better drug may be available to replace the original drug. The patient may have discontinued the drug because he or she could not see why it was necessary; or the patient may have discontinued the drug because of unpleasant side effects. A drug may not work because its absorption is reduced by physical or chemical interaction with another drug or a food component. It may also not work because the patient's metabolism is speeded up or in hibited to an extent such that the desired duration of drug action is not obtained. Such an effect may be related to a change in diet. Side effects may be related to consumption of specific foods or bev erages or to an overall change in nutritional status. Drug-food and drug-alcohol incompatibility reactions are frequent but are avoidable if a patient is warned of their possible occurrence. Drugs may also produce nutritional deficiencies, especially in a patient whose diet is marginal in those nutrients depleted by the particular drug. Careful prescribing practices together with appropriate nutrient supplements will serve to reduce the risk of these incompatibilities.
Author:
Publisher: U.S. Government Printing Office
ISBN:
Category : Business & Economics
Languages : en
Pages : 94
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Book Description
Author: Agency for Health Care Research and Quality (U.S.)
Publisher: Government Printing Office
ISBN: 1587634236
Category : Medical
Languages : en
Pages : 236
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Book Description
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Author: Rhonda M. Strawn
Publisher: Jones & Bartlett Learning
ISBN: 9780763702519
Category : Medical
Languages : en
Pages : 452
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Book Description
Pocket handbook for critical care nurses.
Author: Sid M. Wolfe
Publisher: Simon and Schuster
ISBN: 143913880X
Category : Medical
Languages : en
Pages : 962
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Book Description
"More than 100,000 people a year die in American hospitals from adverse reactions to medication, making drug reactions one of the leading causes of death in this country, researchers are reporting today...." -- Journal of the American Medical Association study, as quoted in The New York Times It is no longer a secret that adverse drug reactions can be dangerous or even fatal, or that doctors often prescribe two relatively safe drugs -- which may cause a life-threatening interaction if taken together. THIS IS THE BOOK THAT TELLS YOU WHAT OTHER PILL BOOKS WON'T ABOUT YOUR MEDICATION! Top-selling drugs that are among the 160 Do Not Use Drugs discussed inside: Ultram Darvoset-N Lopid Desogen & OrthoCept Elavil Ativan Restoril Flexeril Valium Bentyl Entex LA Glucophage Macrobid Patients fill more than 80 million prescriptions a year for these drugs! Consumer advocate Sidney M. Wolfe, M.D., director of Public Citizen's Health Research Group, has thoroughly revised and updated this accessible, indispensable bestseller that alerts you to the potential risks of hundreds of medications available today. Worst Pills, Best Pills gives you the information you need to become actively involved in caring for yourself -- by asking your doctor smart questions about the drugs prescribed for you. Arranged by disease/condition, it offers chapters on adverse drug reactions, alphabetical indexes listing pills by their brand and generic names, new information about commonly used drugs, guidelines for helping you to say "no" if your doctor prescribes a drug you should not take, and safer alternative choices. Worst Pills, Best Pills also includes startling information about certain drugs that can actually cause depression, hallucinations or psychoses, sexual dysfunction, dementia, auto accidents, insomnia, parkinsonism, and more. Caution: Call your doctor before stopping the use of any drug.
Author:
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 1416
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Book Description
Author:
Publisher:
ISBN:
Category : Dermatotoxicology
Languages : en
Pages : 808
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Book Description
Author: Douglas S. Gardenhire
Publisher: Elsevier Health Sciences
ISBN: 0323594662
Category : Medical
Languages : en
Pages : 483
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Book Description
- NEW! Recently-approved FDA medications help familiarize you with current information. - UPDATED All asthma (GINA & NAEPP) and COPD (Gold guidelines) protocols to the latest editions. - UPDATED Enhanced readability helps you to more easily understand difficult material. - NEW! Clinical Connection boxes helps you to connect what you've learned with the clinical setting.
