Author:
Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 414
Book Description
Health Effects Assessment Summary Tables
Author:
Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 414
Book Description
Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 414
Book Description
Drug Transporters in Drug Disposition, Effects and Toxicity
Author: Xiaodong Liu
Publisher: Springer Nature
ISBN: 9811376476
Category : Medical
Languages : en
Pages : 588
Book Description
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Publisher: Springer Nature
ISBN: 9811376476
Category : Medical
Languages : en
Pages : 588
Book Description
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Experiments in Organic Chemistry
Author: Louis Frederick Fieser
Publisher:
ISBN:
Category : Chemistry, Organic
Languages : en
Pages : 369
Book Description
Publisher:
ISBN:
Category : Chemistry, Organic
Languages : en
Pages : 369
Book Description
Forensic Investigation of Clandestine Laboratories
Author: Donnell R. Christian, Jr.
Publisher: CRC Press
ISBN: 9780849312274
Category : Law
Languages : en
Pages : 394
Book Description
Clandestine lab operators are not the mad scientists whose genius keeps them pent up in the laboratory contemplating elaborate formulas and mixing exotic chemicals. In fact, their equipment is usually simple, their chemicals household products, and their education basic. Most of the time the elements at the scene are perfectly legal to sell and own. It is only in the combination of all these elements that the lab becomes the scene of a criminal operation. Forensic Investigation of Clandestine Laboratories guides you, step-by-step, through the process of recognizing these illegal manufacturing operations. Then it shows you how to prove it in the courtroom. In non-technical language this book details: How to recognize a clandestine lab How to process the site of a clandestine lab How to analyze evidence in the examination laboratory What to derive from the physical evidence How to present the evidence in court The identification and investigation of a clandestine lab, and the successful prosecution of the perpetrators, is a team effort. A collaboration of law enforcement, forensic experts, scientists, and criminal prosecutors is required to present a case that definitively demonstrates how a group of items with legitimate uses are being used to manufacture an illegal controlled substance. Providing an understanding of how the pieces of the clandestine lab puzzle fit together, this book outlines the steps needed to identify and shut down these operations, as well as successfully prosecute the perpetrators.
Publisher: CRC Press
ISBN: 9780849312274
Category : Law
Languages : en
Pages : 394
Book Description
Clandestine lab operators are not the mad scientists whose genius keeps them pent up in the laboratory contemplating elaborate formulas and mixing exotic chemicals. In fact, their equipment is usually simple, their chemicals household products, and their education basic. Most of the time the elements at the scene are perfectly legal to sell and own. It is only in the combination of all these elements that the lab becomes the scene of a criminal operation. Forensic Investigation of Clandestine Laboratories guides you, step-by-step, through the process of recognizing these illegal manufacturing operations. Then it shows you how to prove it in the courtroom. In non-technical language this book details: How to recognize a clandestine lab How to process the site of a clandestine lab How to analyze evidence in the examination laboratory What to derive from the physical evidence How to present the evidence in court The identification and investigation of a clandestine lab, and the successful prosecution of the perpetrators, is a team effort. A collaboration of law enforcement, forensic experts, scientists, and criminal prosecutors is required to present a case that definitively demonstrates how a group of items with legitimate uses are being used to manufacture an illegal controlled substance. Providing an understanding of how the pieces of the clandestine lab puzzle fit together, this book outlines the steps needed to identify and shut down these operations, as well as successfully prosecute the perpetrators.
Ammunition and Explosives Safety Standards
Author:
Publisher:
ISBN:
Category : Ammunition
Languages : en
Pages : 108
Book Description
Publisher:
ISBN:
Category : Ammunition
Languages : en
Pages : 108
Book Description
Emerging Energetic Materials: Synthesis, Physicochemical, and Detonation Properties
Author: Dabir S. Viswanath
Publisher: Springer
ISBN: 9402412018
Category : Science
Languages : en
Pages : 477
Book Description
This book summarizes science and technology of a new generation of high-energy andinsensitive explosives. The objective is to provide professionals with comprehensiveinformation on the synthesis and the physicochemical and detonation properties ofthe explosives. Potential technologies applicable for treatment of contaminated wastestreams from manufacturing facilities and environmental matrices are also be included.This book provides the reader an insight into the depth and breadth of theoreticaland empirical models and experimental techniques currently being developed in thefield of energetic materials. It presents the latest research by DoD engineers andscientists, and some of DoD’s academic and industrial researcher partners. The topicsexplored and the simulations developed or modified for the purposes of energetics mayfind application in other closely related fields, such as the pharmaceutical industry.One of the key features of the book is the treatment of wastewaters generated duringmanufacturing of these energetic materials.
Publisher: Springer
ISBN: 9402412018
Category : Science
Languages : en
Pages : 477
Book Description
This book summarizes science and technology of a new generation of high-energy andinsensitive explosives. The objective is to provide professionals with comprehensiveinformation on the synthesis and the physicochemical and detonation properties ofthe explosives. Potential technologies applicable for treatment of contaminated wastestreams from manufacturing facilities and environmental matrices are also be included.This book provides the reader an insight into the depth and breadth of theoreticaland empirical models and experimental techniques currently being developed in thefield of energetic materials. It presents the latest research by DoD engineers andscientists, and some of DoD’s academic and industrial researcher partners. The topicsexplored and the simulations developed or modified for the purposes of energetics mayfind application in other closely related fields, such as the pharmaceutical industry.One of the key features of the book is the treatment of wastewaters generated duringmanufacturing of these energetic materials.
Test Methods for Evaluating Solid Waste: Field manual
Author:
Publisher:
ISBN:
Category : Hazardous wastes
Languages : en
Pages : 354
Book Description
Publisher:
ISBN:
Category : Hazardous wastes
Languages : en
Pages : 354
Book Description
Protein Sequence Determination
Author: Saul B. Needleman
Publisher: Springer Science & Business Media
ISBN: 3662128349
Category : Science
Languages : en
Pages : 363
Book Description
"All the King's horses and all the King's mm couldn't put Humpty Dumpty together again." It is entirely possible that the difficulty facing "all the King's men" was principally the lack of a sufficient guide to the techniques of reassembling from a series of small components, the original entity. It is the sincere hope of the editor of the present work and of each of the contributing authors that the modern researcher will not face a similar predicament in his endeavours to reconstruct the complete primary sequence of a protein from the array of component amino acids. Rather, it is the intent that, with this volume, he may proceed untimorously if not with outright confidence toward achieving his purpose. To the newcomer in protein sequencing, compelled by necessity, or fascination, to investigate the exact order of amino acids in proteins, the question of "where to begin" - or "how to do it" is urgent. To those more skilled, a ready source of additional techniques should nevertheless be of value. This volume attempts to present in a single source a discussion of the methods and techniques useful to the determination of the primary structures of proteins and peptides. Hopefully, this book will tell the reader "how to do it".
Publisher: Springer Science & Business Media
ISBN: 3662128349
Category : Science
Languages : en
Pages : 363
Book Description
"All the King's horses and all the King's mm couldn't put Humpty Dumpty together again." It is entirely possible that the difficulty facing "all the King's men" was principally the lack of a sufficient guide to the techniques of reassembling from a series of small components, the original entity. It is the sincere hope of the editor of the present work and of each of the contributing authors that the modern researcher will not face a similar predicament in his endeavours to reconstruct the complete primary sequence of a protein from the array of component amino acids. Rather, it is the intent that, with this volume, he may proceed untimorously if not with outright confidence toward achieving his purpose. To the newcomer in protein sequencing, compelled by necessity, or fascination, to investigate the exact order of amino acids in proteins, the question of "where to begin" - or "how to do it" is urgent. To those more skilled, a ready source of additional techniques should nevertheless be of value. This volume attempts to present in a single source a discussion of the methods and techniques useful to the determination of the primary structures of proteins and peptides. Hopefully, this book will tell the reader "how to do it".
Military Explosives
Author: Ordnance Department
Publisher: Legare Street Press
ISBN: 9781016219969
Category : Technology & Engineering
Languages : en
Pages : 0
Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Publisher: Legare Street Press
ISBN: 9781016219969
Category : Technology & Engineering
Languages : en
Pages : 0
Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Cleaning Up the Nation's Waste Sites
Author:
Publisher:
ISBN:
Category : Hazardous waste site remediation
Languages : en
Pages : 344
Book Description
Publisher:
ISBN:
Category : Hazardous waste site remediation
Languages : en
Pages : 344
Book Description