Dosimetry for Quantitative Analysis of Low Dose Ionizing Radiation Effects on Humans in Radiation Therapy Patients PDF Download
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 36
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Book Description
We have successfully developed a practical approach to predicting the location of skin surface dose at potential biopsy sites that receive 1 cGy and 10 cGy, respectively, in support of in vivo biologic dosimetry in humans. This represents a significant technical challenge as the sites lie on the patient surface out side the radiation fields. The PEREGRINE Monte Carlo simulation system was used to model radiation dose delivery and TLDs were used for validation on a phantom and confirmation during patient treatment. In the developmental studies the Monte Carlo simulations consistently underestimated the dose at the biopsy site by approximately 15% for a realistic treatment configuration, most likely due to lack of detail in the simulation of the linear accelerator outside the main beam line. Using a single, thickness-independent correction factor for the clinical calculations, the average of 36 measurements for the predicted 1 cGy point was 0.985 cGy (standard deviation: 0.110 cGy) despite patient breathing motion and other real world challenges. Since the 10 cGy point is situated in the region of high dose gradient at the edge of the field, patient motion had a greater effect and the six measured points averaged 5.90 cGy (standard deviation: 1.01 cGy), a difference that is equivalent to approximately a 6 mm shift on the patient's surface.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 36
Get Book Here
Book Description
We have successfully developed a practical approach to predicting the location of skin surface dose at potential biopsy sites that receive 1 cGy and 10 cGy, respectively, in support of in vivo biologic dosimetry in humans. This represents a significant technical challenge as the sites lie on the patient surface out side the radiation fields. The PEREGRINE Monte Carlo simulation system was used to model radiation dose delivery and TLDs were used for validation on a phantom and confirmation during patient treatment. In the developmental studies the Monte Carlo simulations consistently underestimated the dose at the biopsy site by approximately 15% for a realistic treatment configuration, most likely due to lack of detail in the simulation of the linear accelerator outside the main beam line. Using a single, thickness-independent correction factor for the clinical calculations, the average of 36 measurements for the predicted 1 cGy point was 0.985 cGy (standard deviation: 0.110 cGy) despite patient breathing motion and other real world challenges. Since the 10 cGy point is situated in the region of high dose gradient at the edge of the field, patient motion had a greater effect and the six measured points averaged 5.90 cGy (standard deviation: 1.01 cGy), a difference that is equivalent to approximately a 6 mm shift on the patient's surface.
Author: National Research Council
Publisher: National Academies
ISBN: 0309039959
Category : Science
Languages : en
Pages : 436
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Book Description
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author: Kenneth Kase
Publisher: Elsevier
ISBN: 0323150853
Category : Science
Languages : en
Pages : 427
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Book Description
The Dosimetry of Ionizing Radiation, Volume I focuses on the development in radiation dosimetry, which has its origin in the medical application of ionizing radiation with the discovery of X-rays. This book discusses the irradiation of human beings and the biosphere by ionizing radiation from different sources, which is subjected to increased concern and interest due to its possible health effects. Comprised of six chapters, this volume starts with an overview of the factors determining the conversion of the imparted energy into a detectable signal. This text then explores the theoretical basis of microdosimetry and illustrates the numerical data, experimental techniques, and applications of essential concepts and results. Other chapters consider the application of instruments in dose measurements. This book discusses as well the application of radiotherapy for the treatment of malignant diseases. The final chapter deals with the recommended model parameters for internal dosimetry calculations in occupational radiation protection. Physicists, radiation physicists, scientists, and research institutes will find this book useful.
Author: Pedro Andreo
Publisher: John Wiley & Sons
ISBN: 3527808248
Category : Science
Languages : en
Pages : 1310
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Book Description
A new, comprehensively updated edition of the acclaimed textbook by F.H. Attix (Introduction to Radiological Physics and Radiation Dosimetry) taking into account the substantial developments in dosimetry since its first edition. This monograph covers charged and uncharged particle interactions at a level consistent with the advanced use of the Monte Carlo method in dosimetry; radiation quantities, macroscopic behaviour and the characterization of radiation fields and beams are covered in detail. A number of chapters include addenda presenting derivations and discussions that offer new insight into established dosimetric principles and concepts. The theoretical aspects of dosimetry are given in the comprehensive chapter on cavity theory, followed by the description of primary measurement standards, ionization chambers, chemical dosimeters and solid state detectors. Chapters on applications include reference dosimetry for standard and small fields in radiotherapy, diagnostic radiology and interventional procedures, dosimetry of unsealed and sealed radionuclide sources, and neutron beam dosimetry. The topics are presented in a logical, easy-to-follow sequence and the text is supplemented by numerous illustrative diagrams, tables and appendices. For senior undergraduate- or graduate-level students and professionals.
Author: C.G. Orton
Publisher: Springer Science & Business Media
ISBN: 1489905715
Category : Medical
Languages : en
Pages : 338
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Book Description
Mankind has evolved in a sea of radiation. We have been bombarded constantly by X rays, y rays, UV rays, and particulate radiations from outer space, and by terrestrial radiations from the ground we walk on, from our building materials, and from our own bodies. Recently, we have become increasingly subjected to man-made radiations, especially from the medical and defense industries. All of these radiations are capable of affecting us biologically, both to our benefit and to our detriment. This book provides a thorough review of the physical and biological dosimetry of these radiations. It is targeted to those health professionals who are concerned with understanding the mechanisms fundamental to the biological action of ionizing radiation or who are involved in the application, measurement, or treatment of the effects of such radiations. The first chapter, on "Bioeffect Dosimetry in Radiation Therapy," should be of special interest to anyone involved in the treatment of cancer by radiation. It includes a brief review of the history of the manipulation of time-dose parameters in order to improve therapeutic benefit, and an up-to-date analysis of time-dose relationships designed for use in fractionated radiotherapy and brachytherapy. This is followed by two chapters reviewing and comparing national and international protocols for the precise measurement of photon and electron radiations in therapy. These chapters should be invaluable to radiation physicists responsible for treatment machine calibrations.
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher: National Academies Press
ISBN: 0309133343
Category : Science
Languages : en
Pages : 422
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Book Description
This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Author: William Amestoy
Publisher: Springer
ISBN: 3319136267
Category : Medical
Languages : en
Pages : 879
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Book Description
This study guide will be a reliable support and easy-to-use source of information for students in the fields of dosimetry, physics, radiation oncology, and therapy as they progress through the educational levels in preparation for board examinations. The theoretical and practical knowledge gained by students on previous courses or in clinical settings is reinforced by means of almost 1200 questions and accompanying detailed analytical answers. In order to cater for the needs of all students, the questions are arranged according to three levels of difficulty. The level 1 questions are mainly intended for those hoping to pass the Medical Dosimetrist Certification Board (MDCB) exam but will also be beneficial for Medical Physics candidates taking written exams and for Radiation Oncology residents. The level II questions are in general clinically related and will be relevant for any student, while the level III questions are advanced and are especially suitable for American Board of Radiology candidates or those taking equivalent exams elsewhere in the world. The study guide is broken down into different subject areas, with provision of multiple questions and answers on each subject. In addition, the mathematical and physics questions include brief explanations of how the student can solve each problem. At the end of the guide, three practice tests are included with the same number of questions as are found in the MDCB exam. These tests will help students to test their knowledge and improve their test-taking speed.
Author: W. G. Eisert
Publisher: Springer Science & Business Media
ISBN: 3642693342
Category : Medical
Languages : en
Pages : 343
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Book Description
In October 1982, a small international symposium was held at the Gesellschaft fUr Strahlen- und Umweltforschung mbH (GSF) in Munich as a satellite meeting of the IX International Conference on Analytical Cytology. The symposium focussed on cytometric approaches to biological dosimetry, and was, to the best of our knowledge, the first meeting on this subject ever held. There was strong encouragement from the 75 attendees and from others to publish a proceedings of the symposium. Hence this book, containing 30 of the 36 presentations, has been assembled. Dosimetry, the accurate and systematic determination of doses, usually refers to grams of substance administered or rads of ionization or some such measure of exposure of a patient, a victim or an experimental system. The term also can be used to describe the quantity of an ultimate, active agent as delivered to the appropriate target material within a biological system. Thus, for mutagens, one can speak of DNA dosimetry, meaning the number of adducts produced in the DNA of target cells such as bone-mar row stem cells or spermatogonia.
Author: Gad Shani
Publisher: CRC Press
ISBN: 0849315050
Category : Medical
Languages : en
Pages : 506
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Book Description
Radiation dosimetry has made great progress in the last decade, mainly because radiation therapy is much more widely used. Since the first edition, many new developments have been made in the basic methods for dosimetry, i.e. ionization chambers, TLD, chemical dosimeters, and photographic films. Radiation Dosimetry: Instrumentation and Methods, Second Edition brings to the reader these latest developments. Written at a high level for medical physicists, engineers, and advanced dosimetrists, it concentrates only on evolvement during the last decade, relying on the first edition to provide the basics.
Author: Committee on an Assessment of CDC Radiation Studies
Publisher: National Academies Press
ISBN: 0309587131
Category : Medical
Languages : en
Pages : 151
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Book Description
Growing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation. Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation. Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume Provides an overview of the basic requirements and technical aspects of dose reconstruction. Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere. Explores the potential benefits and limitations of biological markers. Discusses how to establish the "source term"--that is, to determine what was released. Explores methods for identifying the environmental pathways by which radiation reaches the body. Offers details on three major categories of dose assessment.
