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Author: Molly Reisner
Publisher: Follettbound
ISBN: 9780329704001
Category : Adventure stories
Languages : en
Pages : 24
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Book Description
Learn how Dora met Boots in this adaptation of a favorite episode, featuring rebus icons.
Author: Molly Reisner
Publisher: Follettbound
ISBN: 9780329704001
Category : Adventure stories
Languages : en
Pages : 24
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Book Description
Learn how Dora met Boots in this adaptation of a favorite episode, featuring rebus icons.
Author: Nickelodeon Publishing
Publisher: Nickelodeon Publishing
ISBN: 1612632637
Category : Juvenile Fiction
Languages : en
Pages : 28
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Book Description
Join Dora the Explorer as she goes exploring for the first time! - Level One expands the vocabulary and uses longer sentences for kids who are just starting to read.
Author:
Publisher: Simon Spotlight/Nickelodeon
ISBN: 9781416968757
Category : Juvenile Fiction
Languages : en
Pages : 28
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Book Description
Learn how Dora met Boots in this adaptation of a favorite episode, featuring rebus icons!
Author:
Publisher:
ISBN: 9788961754460
Category :
Languages : en
Pages :
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Book Description
Author: Katarzyna I. Wojtylak
Publisher: BRILL
ISBN: 9004432671
Category : Language Arts & Disciplines
Languages : en
Pages : 613
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Book Description
A Grammar of Murui (Bue) by Katarzyna Wojtylak is the first complete description of Murui (Witoto, Huitoto) spoken in Colombia and Peru. It is an important contribution to the study of Witotoan languages and linguistic typology of Northwest Amazonia.
Author: Andrew W. Ellis
Publisher: Psychology Press
ISBN: 9780863777158
Category : Psychology
Languages : en
Pages : 708
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Book Description
An extended version of the first edition, this book includes a set of research review papers which supplement the contents of each chapter by providing a discussion of current research issues and detailed investigations of individual cases.
Author: Valérie Guérin
Publisher: Language Science Press
ISBN: 3961101418
Category :
Languages : en
Pages : 296
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Book Description
Many descriptive grammars report the use of a linguistic pattern at the interface between discourse and syntax which is known generally as tail-head linkage. This volume takes an unprecedented look at this type of linkage across languages and shows that there exist three distinct variants, all subsumed under the hypernym bridging constructions. The chapters highlight the defining features of these constructions in the grammar and their functional properties in discourse. The volume reveals that: Bridging constructions consist of two clauses: a reference clause and a bridging clause. Across languages, bridging clauses can be subordinated clauses, reduced main clauses, or main clauses with continuation prosody.Bridging constructions have three variants: recapitulative linkage, summary linkage and mixed linkage. They differ in the formal makeup of the bridging clause.In discourse, the functions that bridging constructions fulfil depend on the text genres in which they appear and their position in the text.If a language uses more than one type of bridging construction, then each type has a distinct discourse function.Bridging constructions can be optional and purely stylistic or mandatory and serve a grammatical purpose.Although the difference between bridging constructions and clause repetition can be subtle, they maintain their own distinctive characteristics.
Author: Bronius Piesarskas
Publisher:
ISBN:
Category :
Languages : lt
Pages : 0
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Book Description
Author: Leslie W. Tari
Publisher: Humana Press
ISBN: 9781617795190
Category : Medical
Languages : en
Pages : 0
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Book Description
The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tackle difficult biological targets with a high probability of success: intact bacterial ribosomes have been structurally elucidated, as well as eukaryotic trans-membrane proteins like the potassium channel and GPCRs. It is now possible for medicinal chemists to have access to structural information on their latest small molecule candidates bound to the therapeutic target within days of compound synthesis, allowing structure guided ligand optimization to occur in "real time". Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Structure-Based Drug Discovery aims to provide scientists interested in adding SBDD to their arsenal of drug discovery methods with well-honed, up-to-date methodologies.
Author: Antonello Mai
Publisher: Springer Nature
ISBN: 3030429822
Category : Science
Languages : en
Pages : 569
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Book Description
This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.