Author: Hermann Senator
Publisher:
ISBN:
Category : Hemorrhagic diseases
Languages : en
Pages : 858

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 944

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Author: Didier Raoult
Publisher: CRC Press
ISBN: 142001997X
Category : Medical
Languages : en
Pages : 400

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Book Description
The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho

Author: Jeffrey J. Zimmerman
Publisher: John Wiley & Sons
ISBN: 1118347145
Category : Medical
Languages : en
Pages : 1012

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Book Description
First published in 1958, Diseases of Swine, Tenth Edition is a fully revised and updated version of this classic reference. Now published in association with the American Association of Swine Veterinarians, the Tenth Edition adds new knowledge throughout in a reorganized format to provide more intuitive access to information. With chapters written by more than 150 of the foremost experts in the field, Diseases of Swine remains the premier source of comprehensive information on swine production, health, and management for swine health specialists of all disciplines and at any level of expertise, including veterinarians, researchers, and students. Featuring a new content organization designed for improved navigability, the Tenth Edition adds chapters on the cardiovascular system, diagnostic tests and test performance, food safety and zoonotic diseases, show and pet pigs, and the most current information on both long-recognized and emerging pathogens. Diseases of Swine, Tenth Edition is an indispensable resource for anyone interested in swine health.

Author: Kansas Medical Society
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 426

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 426

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 818

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 752

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Author: Jong Hoon Park
Publisher: Springer
ISBN: 9811020418
Category : Medical
Languages : en
Pages : 128

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Book Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Author: Association of Military Surgeons of the United States
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1090

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