Development of Novel Polymeric Architectures for Applications in Drug Delivery and Studies Towards the Synthesis of Perfect Polymers by Iterative Exponential Growth "Plus" (IEG+) PDF Download
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Author: Angela Xiaodi Gao
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
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Book Description
Polymeric materials are ubiquitous in numerous facets of everyday life, and their applications will only become increasingly prevalent as the field of polymer science advances. The first chapter of this thesis describes the use of polymeric nanoparticles to overcome challenges in traditional drug delivery. Specifically, a series of novel acid-cleavable bisnorbornene crosslinkers were synthesized and evaluated as building blocks for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. A bis-norbornene acetal structure was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. Combination of this new crosslinker with a novel acid-labile doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release DOX in cell culture. In vitro cell viability studies using HeLa cells confirmed that these constructs are cytotoxic. Even though polymeric materials have found widespread use in current times, polymer science must overcome certain challenges to contend with the needs of next-generation technologies. In particular, newer polymer applications require the use of macromolecules with precisely defined structure and degree of polymerization--challenges that synthetic polymer chemistry has yet to conquer. The second chapter of this thesis describes a novel synthetic methodology (IEG+) that gives polymers with defined molar mass and sequence using synthetic procedures that are precise, scalable, and amenable to diversification. The IEG+ method utilized monomers equipped with orthogonal protecting groups: epoxides and alkynyl silanes. The epoxide functionality served both as a protecting group and as a masked synthon for alcohols, which allowed for side-chain functionalization of the IEG+ scaffold. Combing R- and Smonomers afforded complete stereochemical control of the IEG backbone. Oligomers of unimolecular molar mass and precise chemical structure were successfully prepared.
Author: Angela Xiaodi Gao
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
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Book Description
Polymeric materials are ubiquitous in numerous facets of everyday life, and their applications will only become increasingly prevalent as the field of polymer science advances. The first chapter of this thesis describes the use of polymeric nanoparticles to overcome challenges in traditional drug delivery. Specifically, a series of novel acid-cleavable bisnorbornene crosslinkers were synthesized and evaluated as building blocks for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. A bis-norbornene acetal structure was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. Combination of this new crosslinker with a novel acid-labile doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release DOX in cell culture. In vitro cell viability studies using HeLa cells confirmed that these constructs are cytotoxic. Even though polymeric materials have found widespread use in current times, polymer science must overcome certain challenges to contend with the needs of next-generation technologies. In particular, newer polymer applications require the use of macromolecules with precisely defined structure and degree of polymerization--challenges that synthetic polymer chemistry has yet to conquer. The second chapter of this thesis describes a novel synthetic methodology (IEG+) that gives polymers with defined molar mass and sequence using synthetic procedures that are precise, scalable, and amenable to diversification. The IEG+ method utilized monomers equipped with orthogonal protecting groups: epoxides and alkynyl silanes. The epoxide functionality served both as a protecting group and as a masked synthon for alcohols, which allowed for side-chain functionalization of the IEG+ scaffold. Combing R- and Smonomers afforded complete stereochemical control of the IEG backbone. Oligomers of unimolecular molar mass and precise chemical structure were successfully prepared.
Author: Ambikanandan Misra
Publisher: Elsevier
ISBN: 0128226684
Category : Technology & Engineering
Languages : en
Pages : 594
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Book Description
Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. - Explains how polymers can be prepared and utilized for all major drug delivery routes - Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics - Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects
Author: Yivan Jiang
Publisher:
ISBN:
Category :
Languages : en
Pages : 363
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Book Description
Absolute structural control over polymers - in terms of sequence, length, and stereochemistry - is a Holy Grail of polymer science. Inspired by Nature, polymer chemists over the last century have sought new methods and strategies to control these parameters. An inverse relationship exists, however, between the ability to control the primary structure of a macromolecule and the ability to scale the production of the same macromolecule. In this thesis, we describe the application of iterative exponential growth (IEG) toward the scalable synthesis of sequence-defined, unimolecular, chiral polymers. Using this strategy, we have created a wide array of functional molecularly precise polymers of up to 12.1k kDa in molar mass with various side chains for applications in block copolymer phase segregation, lectin binding, and nanoparticle formulations.
Author: Rebecca A. Bader
Publisher: John Wiley & Sons
ISBN: 1118747801
Category : Social Science
Languages : en
Pages : 395
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Book Description
Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Author: Suresh P Vyas
Publisher: Academic Press
ISBN: 0323913997
Category : Business & Economics
Languages : en
Pages : 626
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Book Description
Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications
Author: Emo Chiellini
Publisher: CRC Press
ISBN: 9780877629290
Category : Technology & Engineering
Languages : en
Pages : 276
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Book Description
The utilization of polymers in medicine has become a reality in the last decade. This book is a concise presentation of the fundamentals, applications, and methods of optimization of polymeric drugs and polymeric drug delivery systems for medicinal purposes. The basic rationale for the use of polymeric drugs and polymer delivery systems is the possibility to alter the pharmacokinetics and pharmacodynamics of therapeutic agents so as to maintain an adequate therapeutic environment at the site of disfunction for an extended period of time. The primary objectives for using polymeric drugs and polymeric drug delivery systems are to introduce new and efficient methods of drug administration, to improve efficacy and patient compliance, to decrease toxicity, and to ensure safety. The following factors influence the design and performance of polymers for medicinal applications: disease, drug properties, type of therapy (acute or chronic), physiology of the patient, administration route, and the site requiring therapy.
Author: Ijeoma F. Uchegbu
Publisher: CRC Press
ISBN: 1000611248
Category : Medical
Languages : en
Pages : 426
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Book Description
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Author: Deepa H. Patel
Publisher: CRC Press
ISBN: 1000517594
Category : Science
Languages : en
Pages : 228
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Book Description
This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.
Author: Peter J. Tarcha
Publisher: CRC Press
ISBN: 1000941116
Category : Medical
Languages : en
Pages : 298
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Book Description
Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Author: Peter J. Tarcha
Publisher: CRC Press
ISBN: 9780849356520
Category : Medical
Languages : en
Pages : 300
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Book Description
Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
