Development of Enantioselective Synthetic Routes to Hasubanan and Acutumine Alkaloids PDF Download
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Author: Nicholas Alexander Calandra
Publisher:
ISBN:
Category :
Languages : en
Pages : 1194
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Book Description
Author: Nicholas Alexander Calandra
Publisher:
ISBN:
Category :
Languages : en
Pages : 1194
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Book Description
Author: Thong Xuan Nguyen
Publisher:
ISBN:
Category :
Languages : en
Pages : 248
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Book Description
Acutumine, a chlorine containing natural product has recently been rediscovered to inhibit T-cell growth, and aid in memory by enhancing memorisation and anti-amnesic properties in mice and rats. These studies reveal the promising benefits of acutumine in alleviating conditions that are related to loss of memory such as Alzheimer's, Parkinson's and Pick's disease. We have developed a synthetic strategy that allows access to the common [4.4.3.0] propellane core structure, including 2,3-dimethoxycyclohexenone and N-methylpyrrolidine moieties, among the hasubanan alkaloids featuring a facile conversion of a sterically hindered amide to ester via N-acylbenzotriazole and a Dieckmann cyclization of cis-fused bicycle to install the propellane framework. It is envisioned that a strategy towards the common propellane core skeleton found in the hasubanan alkaloids can be applied towards the synthesis of acutumine. Progress towards the total synthesis of acutumine is reported, featuring photo[2+2]cycloaddition reactions to install spiro[5.5]ring stereoselectively.
Author: Sandra Marie King
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Masahisa Nakada
Publisher: Springer Nature
ISBN: 9819716195
Category :
Languages : en
Pages : 518
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Author: Elisabeth Brot
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3642340652
Category : Science
Languages : en
Pages : 292
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Book Description
'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author: Arkadi Vigalok
Publisher: Springer
ISBN: 3642120733
Category : Science
Languages : en
Pages : 198
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Book Description
Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.
Author: Ei-ichi Negishi
Publisher: John Wiley & Sons
ISBN: 0471473812
Category : Science
Languages : en
Pages : 1657
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Book Description
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Author: Mahmud Tareq Hassan Khan
Publisher: Springer
ISBN: 3540734066
Category : Science
Languages : en
Pages : 342
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Book Description
With contributions by numerous experts
Author: A. Douglas Kinghorn
Publisher: Springer Nature
ISBN: 3030898733
Category : Science
Languages : en
Pages : 116
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Book Description
This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
