Development of a Monte Carlo-based Electron Beam Treatment Planning System PDF Download
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Author: Abdulkarim A. Al-Beteri
Publisher:
ISBN:
Category : Electron beams
Languages : en
Pages : 440
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Author: Abdulkarim A. Al-Beteri
Publisher:
ISBN:
Category : Electron beams
Languages : en
Pages : 440
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Author: Jonathan Thébaut
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Frank Verhaegen
Publisher: CRC Press
ISBN: 1000455556
Category : Medical
Languages : en
Pages : 291
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Book Description
About ten years after the first edition comes this second edition of Monte Carlo Techniques in Radiation Therapy: Introduction, Source Modelling, and Patient Dose Calculations, thoroughly updated and extended with the latest topics, edited by Frank Verhaegen and Joao Seco. This book aims to provide a brief introduction to the history and basics of Monte Carlo simulation, but again has a strong focus on applications in radiotherapy. Since the first edition, Monte Carlo simulation has found many new applications, which are included in detail. The applications sections in this book cover the following: Modelling transport of photons, electrons, protons, and ions Modelling radiation sources for external beam radiotherapy Modelling radiation sources for brachytherapy Design of radiation sources Modelling dynamic beam delivery Patient dose calculations in external beam radiotherapy Patient dose calculations in brachytherapy Use of artificial intelligence in Monte Carlo simulations This book is intended for both students and professionals, both novice and experienced, in medical radiotherapy physics. It combines overviews of development, methods, and references to facilitate Monte Carlo studies.
Author: Michael C. Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 276
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Author: D. Nigg
Publisher:
ISBN:
Category :
Languages : en
Pages : 28
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The aim of this project is to extend accurate and patient-specific treatment planning to new treatment modalities, such as molecular targeted radiation therapy, incorporating previously crafted and proven Monte Carlo and deterministic computation methods. A flexible software environment is being created that allows planning radiation treatment for these new modalities and combining different forms of radiation treatment with consideration of biological effects. The system uses common input interfaces, medical image sets for definition of patient geometry, and dose reporting protocols. Previously, the Idaho National Engineering and Environmental Laboratory (INEEL), Montana State University (MSU), and Lawrence Livermore National Laboratory (LLNL) had accrued experience in the development and application of Monte Carlo-based, three-dimensional, computational dosimetry and treatment planning tools for radiotherapy in several specialized areas. In particular, INEEL and MSU have developed computational dosimetry systems for neutron radiotherapy and neutron capture therapy, while LLNL has developed the PEREGRINE computational system for external beam photon-electron therapy. Building on that experience, the INEEL and MSU are developing the MINERVA (Modality Inclusive Environment for Radiotherapeutic Variable Analysis) software system as a general framework for computational dosimetry and treatment planning for a variety of emerging forms of radiotherapy. In collaboration with this development, LLNL has extended its PEREGRINE code to accommodate internal sources for molecular targeted radiotherapy (MTR), and has interfaced it with the plug-in architecture of MINERVA. Results from the extended PEREGRINE code have been compared to published data from other codes, and found to be in general agreement (EGS4 - 2%, MCNP - 10%)(Descalle et al. 2003). The code is currently being benchmarked against experimental data. The interpatient variability of the drug pharmacokinetics in MTR can only be properly accounted for by image-based, patient-specific treatment planning as has been common in external beam radiation therapy for many years. MINERVA offers 3D Monte Carlo based MTR treatment planning as its first integrated operational capability. The new MINERVA system will ultimately incorporate capabilities for a comprehensive list of radiation therapies. In progress are modules for external beam photon-electron therapy and Boron Neutron Capture Therapy (BNCT). Brachytherapy and Protontherapy are planned. Through the open Application Programming Interface (API) other groups can add their own modules and share them with the community.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 349
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Book Description
In order to deliver MERT plans efficiently, we have designed and manufactured a prototype EMLC based on the results of Monte Carlo simulations and a Varian 25 x 25 Cm to the 2 electron applicator. The performance of the EMLC was experimentally evaluated and the results were compared with those of Monte Carlo simulations and a PMLC. We have also developed a complete system of Monte Carlo-based inverse treatment planning system for MERT plans. The system incorporates the Monte Carlo simulated electron pencil beams into the inverse planning process. Additionally, we have characterized the EMLC using a multiple-source beam model for fast Monte Carlo simulation, incorporated the EMLC into the EGS/BEAM simulations as an MLC component module, and created MERT plans for breast cancers. We have also studied the effect of beam delivery on optimized modulated electron radiation therapy plans in the final dose calculation. Furthermore, we have developed aperture-based MERT techniques for fast delivery of MERT plans. We believe that MERT provides a viable alternative modality to conventional Opposed tangential fields approach and photon IMRT.
Author: Andrew William Alexander
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Within the field of medical physics, Monte Carlo radiation transport simulations are considered to be the most accurate method for the determination of dose distributions in patients. The McGill Monte Carlo treatment planning system (MMCTP), provides a flexible software environment to integrate Monte Carlo simulations with current and new treatment modalities. A developing treatment modality called energy and intensity modulated electron radiotherapy (MERT) is a promising modality, which has the fundamental capabilities to enhance the dosimetry of superficial targets. An objective of this work is to advance the research and development of MERT with the end goal of clinical use. To this end, we present the MMCTP system with an integrated toolkit for MERT planning and delivery of MERT fields. Delivery is achieved using an automated "few leaf electron collimator" (FLEC) and a controller. Aside from the MERT planning toolkit, the MMCTP system required numerous...
Author: Keivan Jabbari Najafabadi
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
A fast and accurate treatment planning system is essential for radiation therapy and Monte Carlo (MC) techniques produce the most accurate results for dose calculation in treatment planning. In this work, we developed a fast Monte Carlo code based on pre-calculated data (PMC, Pre-calculated Monte Carlo) for applications in radiation therapy treatment planning. The PMC code takes advantage of large available memory in current computer hardware for extensive generation of pre-calculated data. Primary tracks of electrons are generated in the middle of homogeneous materials (water, air, bone, lung) and with energies between 0.2 and 18 MeV using the EGSnrc code. Secondary electrons are not transported but their position, energy, charge and direction are saved and used as a primary particle. Based on medium type and incident electron energy, a track is selected from the pre-calculated set. The performance of the method is tested in various homogeneous and heterogeneous configurations and the results were generally within 2% compared to EGSnrc but with a 40-60 times speed improvement. Pre-calculated Monte Carlo codes are accurate, fast and physics-independent and therefore applicable to different radiation types including heavy-charged particles. In another project, we worked on Monte Carlo feasibility study to use orthogonal bremsstrahlung beams for imaging in radiation therapy. The basic characteristics of orthogonal bremsstrahlung beams are studied and the feasibility of improved contrast imaging in linear accelerator with such a beam is evaluated. In the context of this work orthogonal bremsstrahlung beams represent the component of the bremsstrahlung distribution perpend.
Author: T.M. Jenkins
Publisher: Springer Science & Business Media
ISBN: 1461310598
Category : Science
Languages : en
Pages : 637
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Book Description
For ten days at the end of September, 1987, a group of about 75 scientists from 21 different countries gathered in a restored monastery on a 750 meter high piece of rock jutting out of the Mediterranean Sea to discuss the simulation of the transport of electrons and photons using Monte Carlo techniques. When we first had the idea for this meeting, Ralph Nelson, who had organized a previous course at the "Ettore Majorana" Centre for Scientific Culture, suggested that Erice would be the ideal place for such a meeting. Nahum, Nelson and Rogers became Co-Directors of the Course, with the help of Alessandro Rindi, the Director of the School of Radiation Damage and Protection, and Professor Antonino Zichichi, Director of the "Ettore Majorana" Centre. The course was an outstanding success, both scientifically and socially, and those at the meeting will carry the marks of having attended, both intellectually and on a personal level where many friendships were made. The scientific content of the course was at a very high caliber, both because of the hard work done by all the lecturers in preparing their lectures (e. g. , complete copies of each lecture were available at the beginning of the course) and because of the high quality of the "students", many of whom were accomplished experts in the field. The outstanding facilities of the Centre contributed greatly to the success. This volume contains the formal record of the course lectures.
Author: Ellis Mitrou
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Electron radiotherapy (RT) offers a number of advantages over photons. The high surface dose, combined with a rapid dose fall-off beyond the target volume presents a net increase in tumor control probability and decreases the normal tissue complication for superficial tumors. Electron treatments are normally delivered clinically without previously calculated dose distributions due to the complexity of the electron transport involved and greater error in planning accuracy. This research uses Monte Carlo (MC) methods to model clinical electron beams in order to accurately calculate electron beam dose distributions in patients as well as calculate cutout output factors, reducing the need for a clinical measurement. The present work is incorporated into a research MC calculation system: McGill Monte Carlo Treatment Planning (MMCTP) system. Measurements of PDDs, profiles and output factors in addition to 2D GAFCHROMIC EBT2 film measurements in heterogeneous phantoms...
