Developing Multimodal Therapies for Brain Disorders

Developing Multimodal Therapies for Brain Disorders PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309450268
Category : Medical
Languages : en
Pages : 97

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Book Description
Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potentialâ€"and perhaps essentialâ€"ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.

Developing Multimodal Therapies for Brain Disorders

Developing Multimodal Therapies for Brain Disorders PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309450268
Category : Medical
Languages : en
Pages : 97

Get Book Here

Book Description
Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potentialâ€"and perhaps essentialâ€"ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.

Developing Multimodal Therapies for Brain Disorders

Developing Multimodal Therapies for Brain Disorders PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309450292
Category : Medical
Languages : en
Pages : 97

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Book Description
Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potentialâ€"and perhaps essentialâ€"ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.

Functional Neurologic Disorders

Functional Neurologic Disorders PDF Author:
Publisher: Academic Press
ISBN: 0128018496
Category : Medical
Languages : en
Pages : 684

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Book Description
Functional Neurologic Disorders, the latest volume in the Handbook of Clinical Neurology series, summarizes state-of-the-art research findings and clinical practice on this class of disorders at the interface between neurology and psychiatry. This 51-chapter volume offers an historical introduction, chapters on epidemiology and pathophysiolology, a large section on the clinical features of different type of functional neurologic symptoms and disorders (including functional movement disorders, non-epileptic seizures, dizziness, vision, hearing, speech and cognitive symptoms), and then concluding with approaches to therapy. This group of internationally acclaimed experts in neurology, psychiatry, and neuroscience represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. This HCN volume sets a new landmark standard for a comprehensive, multi-authored work dealing with functional neurologic disorders (also described as psychogenic, dissociative or conversion disorders). - Offers a comprehensive interdisciplinary approach for the care of patients with functional disorders seen in neurologic practice, leading to more efficient prevention, management, and treatment - Provides a synthesis of research efforts incorporating clinical, brain imaging and neurophysiological studies - Fills an existing gap between traditional neurology and traditional psychiatry - Contents include coverage of history, epidemiology, clinical presentations, and therapy - Edited work with chapters authored by leaders in the field, the broadest, most expert coverage available

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine PDF Author: António Salgado
Publisher: Elsevier
ISBN: 0128180854
Category : Medical
Languages : en
Pages : 712

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Book Description
Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. - Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance - Discusses the limitations of present therapies used in the clinics - Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies - Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders

Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders PDF Author: Elizabeth B. Torres
Publisher: Academic Press
ISBN: 0128041188
Category : Medical
Languages : en
Pages : 580

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Book Description
Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders provides a new and unifying methodological framework, introducing new objective biometrics to characterize patterns of sensory motor control underlying symptoms. Its goal is to radically transform the ways in which disorders of the nervous system are currently diagnosed, tracked, researched and treated. This book introduces new ways to bring the laboratory to the clinical setting, to schools and to settings of occupational and physical therapy. Ready-to-use, graphic user interfaces are introduced to provide outcome measures from wearable sensors that automatically assess in near real time the effectiveness of interventions. Lastly, examples of how the new framework has been effectively utilized in the context of clinical trials are provided. - Provides methods and their implementation using real data and simple computer programs that students and researchers from less technically trained fields can use - Describes the motivation for methods according to the problem domain in light of existing methods for each chapter, along with their lack of neuroscientific foundation and invalid statistical assumptions - Accompanied by a companion website which contains Appendices with MATLAB codes and data samples to generate the graphics displayed in all chapter figures - Features videos illustrating the experimental set up for scenarios and methods described in each chapter - Includes step-by-step explanations of paradigms in each clinical or typical sample population to enable reproducibility of the study across different clinical phenotypes and levels of expertise in sports, the performing arts, or mere individual academic predispositions/preferences

Another Generation of Fundamental Considerations in Language Assessment

Another Generation of Fundamental Considerations in Language Assessment PDF Author: Gary J. Ockey
Publisher: Springer Nature
ISBN: 9811589526
Category : Education
Languages : en
Pages : 268

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Book Description
This edited book is a collection of papers, written by language assessment professionals to reflect the guidance of Professor Lyle F. Bachman, one of the leading second language assessment experts in the field for decades. It has three sub-themes: assessment of evolving language ability constructs, validity and validation of language assessments, and understanding internal structures of language assessments. It provides theoretical guidelines for practical language assessment challenges. Chapters are written by language assessment researchers who graduated from the University of California, Los Angeles, where Professor Bachman trained them including the book editors.

Personalized Psychiatry

Personalized Psychiatry PDF Author: Bernhard Baune
Publisher: Academic Press
ISBN: 0128131772
Category : Medical
Languages : en
Pages : 594

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Book Description
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Attention Deficit Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder PDF Author: Lily Trokenberg Hechtman
Publisher: Oxford University Press
ISBN: 0190213582
Category : Medical
Languages : en
Pages : 329

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Book Description
Comprehensive description of adult outcome in educational, occupational, emotional, social, substance use, legal, antisocial functioning is described via the best well-controlled prospective follow-up studies of children with ADHD into adulthood. Predictors of outcome, e.g., medication and psychosocial treatment, IQ, severity of ADHD, comorbidity, SES, parental pathology and family functioning are all explored. Prognosis and issues that need to be addressed to promote more positive outcome are thus addressed.

Hands-On Machine Learning with R

Hands-On Machine Learning with R PDF Author: Brad Boehmke
Publisher: CRC Press
ISBN: 1000730433
Category : Business & Economics
Languages : en
Pages : 373

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Book Description
Hands-on Machine Learning with R provides a practical and applied approach to learning and developing intuition into today’s most popular machine learning methods. This book serves as a practitioner’s guide to the machine learning process and is meant to help the reader learn to apply the machine learning stack within R, which includes using various R packages such as glmnet, h2o, ranger, xgboost, keras, and others to effectively model and gain insight from their data. The book favors a hands-on approach, providing an intuitive understanding of machine learning concepts through concrete examples and just a little bit of theory. Throughout this book, the reader will be exposed to the entire machine learning process including feature engineering, resampling, hyperparameter tuning, model evaluation, and interpretation. The reader will be exposed to powerful algorithms such as regularized regression, random forests, gradient boosting machines, deep learning, generalized low rank models, and more! By favoring a hands-on approach and using real word data, the reader will gain an intuitive understanding of the architectures and engines that drive these algorithms and packages, understand when and how to tune the various hyperparameters, and be able to interpret model results. By the end of this book, the reader should have a firm grasp of R’s machine learning stack and be able to implement a systematic approach for producing high quality modeling results. Features: · Offers a practical and applied introduction to the most popular machine learning methods. · Topics covered include feature engineering, resampling, deep learning and more. · Uses a hands-on approach and real world data.

Photobiomodulation in the Brain

Photobiomodulation in the Brain PDF Author: Michael R. Hamblin
Publisher: Academic Press
ISBN: 0128153067
Category : Medical
Languages : en
Pages : 658

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Book Description
Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation's science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders. - Provides a much-needed reference on photobiomodulation with an unprecedented focus on the brain and its disorders - Features a body of world-renowned editors and chapter authors that promote research, policy and funding - Discusses the recent and rapid accumulation of literature in this area of research and the shift towards the use of non-invasive techniques in therapy