Developing Computational Methods for Fundamentals and Metrology of Mass Spectrometry Imaging PDF Download
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Author: Alexander Dexter
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Alexander Dexter
Publisher:
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Category :
Languages : en
Pages :
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Author: Robin Schmid
Publisher:
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Category :
Languages : en
Pages :
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Author: Tiffany Siegel Porta
Publisher: Royal Society of Chemistry
ISBN: 1839162414
Category : Science
Languages : en
Pages : 541
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Book Description
This book gathers knowledge about matrix-assisted laser desorption ionisation (MALDI) mass spectrometry imaging for postgraduate and professional researchers in academia and in industry where it has direct application to clinical research.
Author: Laura M Cole
Publisher: Springer Nature
ISBN: 1071633198
Category : Science
Languages : en
Pages : 217
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Book Description
This second edition details new and updated chapters on key methodologies and breakthroughs in the mass spectrometry imaging (MSI) field. Chapters guide readers through nano-Desorption Electrospray Ionisation (nDESI), Matrix Assisted Laser Desorption Ionisation-2 (MALDI-2), Laser Ablation - Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) ,Imaging Mass Cytometry (IMC) with a variety of diverse samples including eye tissue, crop analysis, 3D cell culture models, and counterfeit goods analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Imaging Mass Spectrometry: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Author: Purva Kulkarni
Publisher:
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Category :
Languages : en
Pages :
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A powerful enhancement to MS-based detection is the addition of spatial information to the chemical data; an approach called mass spectrometry imaging (MSI). MSI enables two- and three-dimensional overviews of hundreds of molecular species over a wide mass range in complex biological samples. In this work, we present two computational methods and a workflow that address three different aspects of MSI data analysis: correction of mass shifts, unsupervised exploration of the data and importance of preprocessing and chemometrics to extract meaningful information from the data. We introduce a new lock mass-free recalibration procedure that enables to significantly reduce these mass shift effects in MSI data. Our method exploits similarities amongst peaklist pairs and takes advantage of the spatial context in three different ways, to perform mass correction in an iterative manner. As an extension of this work, we also present a Java-based tool, MSICorrect, that implements our recalibration approach and also allows data visualization. In the next part, an unsupervised approach to rank ion intensity maps based on the abundance of their spatial pattern is presented. Our method provides a score to every ion intensity map based on the abundance of spatial pattern present in it and then ranks all the maps using it. To know which masses exhibit similar spatial distribution, our method uses spatial-similarity based grouping to provide lists of masses that exhibit similar distribution patterns. In the last part, we demonstrate the application of a data preprocessing and multivariate analysis pipeline to a real-world biological dataset. We demonstrate this by applying the full pipeline to a high-resolution MSI dataset acquired from the leaf surface of Black cottonwood (Populus trichocarpa). Application of the pipeline helped in highlighting and visualizing the chemical specificity on the leaf surface.
Author: Karl Michael Stefan Hanselmann
Publisher:
ISBN:
Category :
Languages : en
Pages : 172
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Author: Johan Lillja
Publisher:
ISBN: 9789151318707
Category :
Languages : en
Pages : 0
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Author: Qiang Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 116
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Keywords: machaniam, metabolite, mass spectrometry, imaging mass spectrometry, MS.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309168392
Category : Science
Languages : en
Pages : 238
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Book Description
Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Author: ConferenceSeries
Publisher: ConferenceSeries
ISBN:
Category :
Languages : en
Pages : 102
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Book Description
June 20-22, 2018 Rome, Italy Key topics : Applications of Mass Spectrometry, New Approaches in Mass Spectrometry, Recent Advances and Development in Mass Spectrometry, Mass spectrometry imaging, Fundamentals of Mass Spectrometry, Ionization Techniques, Chromatography and High Performance Liquid Chromatography (HPLC), Mass Spectrometry in Proteome Research, Proteomics and its applications, Hyphenated Techniques, Spectroscopy, Maintenance, Troubleshooting, Data Analysis and Experimentation in Mass Spectrometry, Analytical Science and Separation Techniques,
