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Author: Oliviero Carugo
Publisher: Humana
ISBN: 9781493956883
Category : Science
Languages : en
Pages : 407
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Book Description
Most life science researchers will agree that biology is not a truly theoretical branch of science. The hype around computational biology and bioinformatics beginning in the nineties of the 20th century was to be short lived (1, 2). When almost no value of practical importance such as the optimal dose of a drug or the three-dimensional structure of an orphan protein can be computed from fundamental principles, it is still more straightforward to determine them experimentally. Thus, experiments and observationsdogeneratetheoverwhelmingpartofinsightsintobiologyandmedicine. The extrapolation depth and the prediction power of the theoretical argument in life sciences still have a long way to go. Yet, two trends have qualitatively changed the way how biological research is done today. The number of researchers has dramatically grown and they, armed with the same protocols, have produced lots of similarly structured data. Finally, high-throu- put technologies such as DNA sequencing or array-based expression profiling have been around for just a decade. Nevertheless, with their high level of uniform data generation, they reach the threshold of totally describing a living organism at the biomolecular level for the first time in human history. Whereas getting exact data about living systems and the sophistication of experimental procedures have primarily absorbed the minds of researchers previously, the weight increasingly shifts to the problem of interpreting accumulated data in terms of biological function and bio- lecular mechanisms.
Author: Oliviero Carugo
Publisher: Humana
ISBN: 9781493956883
Category : Science
Languages : en
Pages : 407
Get Book Here
Book Description
Most life science researchers will agree that biology is not a truly theoretical branch of science. The hype around computational biology and bioinformatics beginning in the nineties of the 20th century was to be short lived (1, 2). When almost no value of practical importance such as the optimal dose of a drug or the three-dimensional structure of an orphan protein can be computed from fundamental principles, it is still more straightforward to determine them experimentally. Thus, experiments and observationsdogeneratetheoverwhelmingpartofinsightsintobiologyandmedicine. The extrapolation depth and the prediction power of the theoretical argument in life sciences still have a long way to go. Yet, two trends have qualitatively changed the way how biological research is done today. The number of researchers has dramatically grown and they, armed with the same protocols, have produced lots of similarly structured data. Finally, high-throu- put technologies such as DNA sequencing or array-based expression profiling have been around for just a decade. Nevertheless, with their high level of uniform data generation, they reach the threshold of totally describing a living organism at the biomolecular level for the first time in human history. Whereas getting exact data about living systems and the sophistication of experimental procedures have primarily absorbed the minds of researchers previously, the weight increasingly shifts to the problem of interpreting accumulated data in terms of biological function and bio- lecular mechanisms.
Author: Stephen T. C. Wong
Publisher: World Scientific Publishing Company
ISBN:
Category : Computers
Languages : en
Pages : 392
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Book Description
This timely book identifies and highlights the latest data mining paradigms to analyze, combine, integrate, model and simulate vast amounts of heterogeneous multi-modal, multi-scale data for emerging real-world applications in life science.The cutting-edge topics presented include bio-surveillance, disease outbreak detection, high throughput bioimaging, drug screening, predictive toxicology, biosensors, and the integration of macro-scale bio-surveillance and environmental data with micro-scale biological data for personalized medicine. This collection of works from leading researchers in the field offers readers an exceptional start in these areas.
Author: Ian H. Witten
Publisher: Elsevier
ISBN: 008047702X
Category : Computers
Languages : en
Pages : 558
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Book Description
Data Mining, Second Edition, describes data mining techniques and shows how they work. The book is a major revision of the first edition that appeared in 1999. While the basic core remains the same, it has been updated to reflect the changes that have taken place over five years, and now has nearly double the references. The highlights of this new edition include thirty new technique sections; an enhanced Weka machine learning workbench, which now features an interactive interface; comprehensive information on neural networks; a new section on Bayesian networks; and much more. This text is designed for information systems practitioners, programmers, consultants, developers, information technology managers, specification writers as well as professors and students of graduate-level data mining and machine learning courses. - Algorithmic methods at the heart of successful data mining—including tried and true techniques as well as leading edge methods - Performance improvement techniques that work by transforming the input or output
Author: Jiawei Han
Publisher: Elsevier
ISBN: 0123814804
Category : Computers
Languages : en
Pages : 740
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Book Description
Data Mining: Concepts and Techniques provides the concepts and techniques in processing gathered data or information, which will be used in various applications. Specifically, it explains data mining and the tools used in discovering knowledge from the collected data. This book is referred as the knowledge discovery from data (KDD). It focuses on the feasibility, usefulness, effectiveness, and scalability of techniques of large data sets. After describing data mining, this edition explains the methods of knowing, preprocessing, processing, and warehousing data. It then presents information about data warehouses, online analytical processing (OLAP), and data cube technology. Then, the methods involved in mining frequent patterns, associations, and correlations for large data sets are described. The book details the methods for data classification and introduces the concepts and methods for data clustering. The remaining chapters discuss the outlier detection and the trends, applications, and research frontiers in data mining. This book is intended for Computer Science students, application developers, business professionals, and researchers who seek information on data mining. - Presents dozens of algorithms and implementation examples, all in pseudo-code and suitable for use in real-world, large-scale data mining projects - Addresses advanced topics such as mining object-relational databases, spatial databases, multimedia databases, time-series databases, text databases, the World Wide Web, and applications in several fields - Provides a comprehensive, practical look at the concepts and techniques you need to get the most out of your data
Author: Rob Sullivan
Publisher: Springer Science & Business Media
ISBN: 1597452904
Category : Science
Languages : en
Pages : 644
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Book Description
Data mining provides a set of new techniques to integrate, synthesize, and analyze tdata, uncovering the hidden patterns that exist within. Traditionally, techniques such as kernel learning methods, pattern recognition, and data mining, have been the domain of researchers in areas such as artificial intelligence, but leveraging these tools, techniques, and concepts against your data asset to identify problems early, understand interactions that exist and highlight previously unrealized relationships through the combination of these different disciplines can provide significant value for the investigator and her organization.
Author: Werner Dubitzky
Publisher: Springer Science & Business Media
ISBN: 0387475095
Category : Science
Languages : en
Pages : 300
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Book Description
This book presents state-of-the-art analytical methods from statistics and data mining for the analysis of high-throughput data from genomics and proteomics. It adopts an approach focusing on concepts and applications and presents key analytical techniques for the analysis of genomics and proteomics data by detailing their underlying principles, merits and limitations.
Author: Jason T. L. Wang
Publisher: Springer Science & Business Media
ISBN: 9781852336714
Category : Computers
Languages : en
Pages : 356
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Book Description
Written especially for computer scientists, all necessary biology is explained. Presents new techniques on gene expression data mining, gene mapping for disease detection, and phylogenetic knowledge discovery.
Author: Xiaoli Li
Publisher: World Scientific
ISBN: 9814551023
Category : Science
Languages : en
Pages : 437
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Book Description
Biologists are stepping up their efforts in understanding the biological processes that underlie disease pathways in the clinical contexts. This has resulted in a flood of biological and clinical data from genomic and protein sequences, DNA microarrays, protein interactions, biomedical images, to disease pathways and electronic health records. To exploit these data for discovering new knowledge that can be translated into clinical applications, there are fundamental data analysis difficulties that have to be overcome. Practical issues such as handling noisy and incomplete data, processing compute-intensive tasks, and integrating various data sources, are new challenges faced by biologists in the post-genome era. This book will cover the fundamentals of state-of-the-art data mining techniques which have been designed to handle such challenging data analysis problems, and demonstrate with real applications how biologists and clinical scientists can employ data mining to enable them to make meaningful observations and discoveries from a wide array of heterogeneous data from molecular biology to pharmaceutical and clinical domains.
Author: Ian H. Witten
Publisher: Morgan Kaufmann
ISBN: 9781558605527
Category : Computers
Languages : en
Pages : 414
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Book Description
This book offers a thorough grounding in machine learning concepts combined with practical advice on applying machine learning tools and techniques in real-world data mining situations. Clearly written and effectively illustrated, this book is ideal for anyone involved at any level in the work of extracting usable knowledge from large collections of data. Complementing the book's instruction is fully functional machine learning software.
Author: John J. McArdle
Publisher: Routledge
ISBN: 1135044090
Category : Psychology
Languages : en
Pages : 496
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Book Description
This book reviews the latest techniques in exploratory data mining (EDM) for the analysis of data in the social and behavioral sciences to help researchers assess the predictive value of different combinations of variables in large data sets. Methodological findings and conceptual models that explain reliable EDM techniques for predicting and understanding various risk mechanisms are integrated throughout. Numerous examples illustrate the use of these techniques in practice. Contributors provide insight through hands-on experiences with their own use of EDM techniques in various settings. Readers are also introduced to the most popular EDM software programs. A related website at http://mephisto.unige.ch/pub/edm-book-supplement/offers color versions of the book’s figures, a supplemental paper to chapter 3, and R commands for some chapters. The results of EDM analyses can be perilous – they are often taken as predictions with little regard for cross-validating the results. This carelessness can be catastrophic in terms of money lost or patients misdiagnosed. This book addresses these concerns and advocates for the development of checks and balances for EDM analyses. Both the promises and the perils of EDM are addressed. Editors McArdle and Ritschard taught the "Exploratory Data Mining" Advanced Training Institute of the American Psychological Association (APA). All contributors are top researchers from the US and Europe. Organized into two parts--methodology and applications, the techniques covered include decision, regression, and SEM tree models, growth mixture modeling, and time based categorical sequential analysis. Some of the applications of EDM (and the corresponding data) explored include: selection to college based on risky prior academic profiles the decline of cognitive abilities in older persons global perceptions of stress in adulthood predicting mortality from demographics and cognitive abilities risk factors during pregnancy and the impact on neonatal development Intended as a reference for researchers, methodologists, and advanced students in the social and behavioral sciences including psychology, sociology, business, econometrics, and medicine, interested in learning to apply the latest exploratory data mining techniques. Prerequisites include a basic class in statistics.
