Fundamental Statistical Methods for Analysis of Alzheimer's and Other Neurodegenerative Diseases PDF Download
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Author: Katherine E. Irimata
Publisher: Johns Hopkins University Press
ISBN: 142143671X
Category : Medical
Languages : en
Pages : 481
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Book Description
A statistics textbook that delivers essential data analysis techniques for Alzheimer's and other neurodegenerative diseases. Alzheimer's disease is a devastating condition that presents overwhelming challenges to patients and caregivers. In the face of this relentless and as-yet incurable disease, mastery of statistical analysis is paramount for anyone who must assess complex data that could improve treatment options. This unique book presents up-to-date statistical techniques commonly used in the analysis of data on Alzheimer's and other neurodegenerative diseases. With examples drawn from the real world that will make it accessible to disease researchers, practitioners, academics, and students alike, this volume • presents code for analyzing dementia data in statistical programs, including SAS, R, SPSS, and Stata • introduces statistical models for a range of data types, including continuous, categorical, and binary responses, as well as correlated data • draws on datasets from the National Alzheimer's Coordinating Center, a large relational database of standardized clinical and neuropathological research data • discusses advanced statistical methods, including hierarchical models, survival analysis, and multiple-membership • examines big data analytics and machine learning methods Easy to understand but sophisticated in its approach, Fundamental Statistical Methods for Analysis of Alzheimer's and Other Neurodegenerative Diseases will be a cornerstone for anyone looking for simplicity in understanding basic and advanced statistical data analysis topics. Allowing more people to aid in analyzing data—while promoting constructive dialogues with statisticians—this book will hopefully play an important part in unlocking the secrets of these confounding diseases.
Author: Katherine E. Irimata
Publisher: Johns Hopkins University Press
ISBN: 142143671X
Category : Medical
Languages : en
Pages : 481
Get Book Here
Book Description
A statistics textbook that delivers essential data analysis techniques for Alzheimer's and other neurodegenerative diseases. Alzheimer's disease is a devastating condition that presents overwhelming challenges to patients and caregivers. In the face of this relentless and as-yet incurable disease, mastery of statistical analysis is paramount for anyone who must assess complex data that could improve treatment options. This unique book presents up-to-date statistical techniques commonly used in the analysis of data on Alzheimer's and other neurodegenerative diseases. With examples drawn from the real world that will make it accessible to disease researchers, practitioners, academics, and students alike, this volume • presents code for analyzing dementia data in statistical programs, including SAS, R, SPSS, and Stata • introduces statistical models for a range of data types, including continuous, categorical, and binary responses, as well as correlated data • draws on datasets from the National Alzheimer's Coordinating Center, a large relational database of standardized clinical and neuropathological research data • discusses advanced statistical methods, including hierarchical models, survival analysis, and multiple-membership • examines big data analytics and machine learning methods Easy to understand but sophisticated in its approach, Fundamental Statistical Methods for Analysis of Alzheimer's and Other Neurodegenerative Diseases will be a cornerstone for anyone looking for simplicity in understanding basic and advanced statistical data analysis topics. Allowing more people to aid in analyzing data—while promoting constructive dialogues with statisticians—this book will hopefully play an important part in unlocking the secrets of these confounding diseases.
Author: Deepika Koundal
Publisher: Springer Nature
ISBN: 9819921546
Category : Medical
Languages : en
Pages : 267
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Book Description
This book explores the challenges involved in handling medical big data in the diagnosis of neurological disorders. It discusses how to optimally reduce the number of neuropsychological tests during the classification of these disorders by using feature selection methods based on the diagnostic information of enrolled subjects. The book includes key definitions/models and covers their applications in different types of signal/image processing for neurological disorder data. An extensive discussion on the possibility of enhancing the abilities of AI systems using the different data analysis is included. The book recollects several applicable basic preliminaries of the different AI networks and models, while also highlighting basic processes in image processing for various neurological disorders. It also reports on several applications to image processing and explores numerous topics concerning the role of big data analysis in addressing signal and image processing in various real-world scenarios involving neurological disorders. This cutting-edge book highlights the analysis of medical data, together with novel procedures and challenges for handling neurological signals and images. It will help engineers, researchers and software developers to understand the concepts and different models of AI and data analysis. To help readers gain a comprehensive grasp of the subject, it focuses on three key features: ● Presents outstanding concepts and models for using AI in clinical applications involving neurological disorders, with clear descriptions of image representation, feature extraction and selection. ● Highlights a range of techniques for evaluating the performance of proposed CAD systems for the diagnosis of neurological disorders. ● Examines various signal and image processing methods for efficient decision support systems. Soft computing, machine learning and optimization algorithms are also included to improve the CAD systems used.
Author: Philip V. Peplow
Publisher:
ISBN: 9781071617120
Category : Biochemical markers
Languages : en
Pages : 565
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Book Description
This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
Author: Rani, Geeta
Publisher: IGI Global
ISBN: 1799827437
Category : Medical
Languages : en
Pages : 586
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Book Description
By applying data analytics techniques and machine learning algorithms to predict disease, medical practitioners can more accurately diagnose and treat patients. However, researchers face problems in identifying suitable algorithms for pre-processing, transformations, and the integration of clinical data in a single module, as well as seeking different ways to build and evaluate models. The Handbook of Research on Disease Prediction Through Data Analytics and Machine Learning is a pivotal reference source that explores the application of algorithms to making disease predictions through the identification of symptoms and information retrieval from images such as MRIs, ECGs, EEGs, etc. Highlighting a wide range of topics including clinical decision support systems, biomedical image analysis, and prediction models, this book is ideally designed for clinicians, physicians, programmers, computer engineers, IT specialists, data analysts, hospital administrators, researchers, academicians, and graduate and post-graduate students.
Author: Luca Saba
Publisher: Oxford University Press, USA
ISBN: 0199671613
Category : Medical
Languages : en
Pages : 585
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Book Description
This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.
Author: Damir Janigro
Publisher: Springer Science & Business Media
ISBN: 1597450219
Category : Medical
Languages : en
Pages : 555
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Book Description
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
Author: G. Ali Qureshi
Publisher: Elsevier
ISBN: 0080489494
Category : Science
Languages : en
Pages : 795
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Book Description
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Author: Mahendra Rai
Publisher: Springer Nature
ISBN: 3030309304
Category : Medical
Languages : en
Pages : 403
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Book Description
This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.
Author: M. Mohamed Essa
Publisher: Springer
ISBN: 3319283839
Category : Medical
Languages : en
Pages : 497
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Book Description
Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
Author: D. Jude Hemanth
Publisher: Academic Press
ISBN: 0128222727
Category : Science
Languages : en
Pages : 322
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Book Description
Handbook of Decision Support Systems for Neurological Disorders provides readers with complete coverage of advanced computer-aided diagnosis systems for neurological disorders. While computer-aided decision support systems for different medical imaging modalities are available, this is the first book to solely concentrate on decision support systems for neurological disorders. Due to the increase in the prevalence of diseases such as Alzheimer, Parkinson's and Dementia, this book will have significant importance in the medical field. Topics discussed include recent computational approaches, different types of neurological disorders, deep convolution neural networks, generative adversarial networks, auto encoders, recurrent neural networks, and modified/hybrid artificial neural networks. - Includes applications of computer intelligence and decision support systems for the diagnosis and analysis of a variety of neurological disorders - Presents in-depth, technical coverage of computer-aided systems for tumor image classification, Alzheimer's disease detection, dementia detection using deep belief neural networks, and morphological approaches for stroke detection - Covers disease diagnosis for cerebral palsy using auto-encoder approaches, contrast enhancement for performance enhanced diagnosis systems, autism detection using fuzzy logic systems, and autism detection using generative adversarial networks - Written by engineers to help engineers, computer scientists, researchers and clinicians understand the technology and applications of decision support systems for neurological disorders
