Cytokeratins in Intracranial and Intraspinal Tissues PDF Download
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Author: Michael Bauer
Publisher: Springer Science & Business Media
ISBN: 3642772986
Category : Science
Languages : en
Pages : 125
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Book Description
This book summarises current immunomorphological data of cytokeratin detection in the various cell types of intracranial and intraspinal tissues.The methodical problems of their detection are discussed as well as the interspecies variability in the expression of intermediate filaments. Together with the microtubuli and the microfilaments, intermediate filament proteins represent the main constituents of the vertebrate cell cytoskeleton. The review specifically focuses on the most up-to-date material concerning cytokeratin expression inselected neutoectodermal tissues, for which only sparse results exist. Essential information on the latest findings in this field coupled with new experimental data by the author are provided in this volume. Chapters review methodical aspects and problems in the evaluation of filament proteins by immunocytochemistry and explore the relationship of cytokeratin expression to cellular differentiation. Also discussed are: function of intermediate filaments; species differences in the expression during ontogeny; and pathologic alteration of tissues and tumor development.
Author: Michael Bauer
Publisher: Springer Science & Business Media
ISBN: 3642772986
Category : Science
Languages : en
Pages : 125
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Book Description
This book summarises current immunomorphological data of cytokeratin detection in the various cell types of intracranial and intraspinal tissues.The methodical problems of their detection are discussed as well as the interspecies variability in the expression of intermediate filaments. Together with the microtubuli and the microfilaments, intermediate filament proteins represent the main constituents of the vertebrate cell cytoskeleton. The review specifically focuses on the most up-to-date material concerning cytokeratin expression inselected neutoectodermal tissues, for which only sparse results exist. Essential information on the latest findings in this field coupled with new experimental data by the author are provided in this volume. Chapters review methodical aspects and problems in the evaluation of filament proteins by immunocytochemistry and explore the relationship of cytokeratin expression to cellular differentiation. Also discussed are: function of intermediate filaments; species differences in the expression during ontogeny; and pathologic alteration of tissues and tumor development.
Author: Gerhard Hamilton
Publisher: BoD – Books on Demand
ISBN: 9535100475
Category : Medical
Languages : en
Pages : 174
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Book Description
The first chapters of the volume "Cytokeratins - Tools in Oncology" discuss multiple functions of cytokeratins in organization of the intermediary filaments in normal intestine and liver as well as microfold L cells and the usability of cytokeratins 7, 8 and 20 in tumor diagnosis in detail. Epithelial to mesenchymal transition as a mechanism important in pathogenesis is touched in another chapter, followed by several articles dealing with the role of cytokeratins for detection of disseminated tumor cells and as response markers during chemotherapy. This book is therefore destined to all cancer researchers and therapists who want to understand the diagnostic application of cytokeratins in histology and, especially, the use of anti-cytokeratin antibodies to identify viable residual tumor cells accounting for a higher risk of tumor recurrence or cancer cells responding to chemotherapy, respectively.
Author: Muin S.A. Tuffaha
Publisher: Springer Nature
ISBN: 3031450248
Category : Medical
Languages : en
Pages : 373
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Book Description
This new and updated edition provides an extensive overview of the antibodies employed in diagnostic tumor histopathology, and it presents concise summaries of the immunoprofiles of most tumors. Additionally, it offers practical diagnostic algorithms and invaluable tips to facilitate the interpretation of results. The work includes the newest available antibodies and the most recent 5th edition of the WHO classification of tumors. Furthermore, a chapter on biomarkers for theranostic applications has been added to enhance the book's utility. Designed as a practical and user-friendly bench reference for diagnostic tumor histopathology, this book is recommended to histopathologists of all levels, from aspiring residents to seasoned specialists seeking a reliable and comprehensive resource for tumor diagnostics. Moreover, it is highly recommended for oncologists, hematologists, and researchers involved in these fields.
Author: Natasha Rekhtman
Publisher: Springer Science & Business Media
ISBN: 3642200869
Category : Medical
Languages : en
Pages : 188
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Book Description
This book is a compilation of high-yield, at-a-glance summaries for various topics on which pathologists frequently need information in a quick reference format while at the microscope (or when cramming for the boards). The authors are early-career pathologists who have compiled this book from the perspective of pathologists-in-training. The focus is not organ-based histologic criteria, but rather everything else that goes into pathologic diagnoses but is difficult to keep committed to memory. The emphasis is on immunohistochemistry, special stains, grading systems, molecular markers, tumor syndromes, and helpful clinical references. The book has a unique format in that the information is presented primarily in tables and diagrams accompanied by minimal explanatory text. It is intended to serve as a ‘peripheral brain’ for pathology residents and also practicing pathologists, where frequently needed information is readily accessible and easy to navigate.
Author: Runjan Chetty
Publisher: Cambridge University Press
ISBN: 1316592065
Category : Medical
Languages : en
Pages : 525
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Book Description
Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.
Author: Arie Perry
Publisher: Elsevier Health Sciences
ISBN: 0323508669
Category : Medical
Languages : en
Pages : 782
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Book Description
Part of the in-depth and practical Pattern Recognition series, Practical Surgical Neuropathology, 2nd Edition, by Drs. Arie Perry and Daniel J. Brat, helps you arrive at an accurate CNS diagnosis by using a pattern-based approach. Leading diagnosticians in neuropathology guide you from a histological (and/or clinical, radiologic, and molecular) pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Almost 2,000 high-quality illustrations capture key neuropathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. - Instructive algorithms provide detailed guidance based on 8 major (scanning magnification) patterns and 20 minor (high magnification) patterns – helping you narrow the range of diagnostic possibilities. - A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables, charts, and graphs so you can quickly and easily find what you are looking for. Sweeping content updates. Patterns call-outs throughout. The patterns described initially in the text will be better linked directly within the chapter, reinforcing the patterns for further understanding.
Author: Peiguo Chu
Publisher: Cambridge University Press
ISBN: 1316184455
Category : Medical
Languages : en
Pages : 1179
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Book Description
Since the publication of the first edition of this best-selling book in 2009, the field of immunohistochemistry has advanced significantly. Fully updated to reflect the latest developments in the field, Modern Immunohistochemistry, Second Edition, is a practical guide to all the important diagnostic markers in each organ system. Concise text is supplemented by over 1,100 high-quality colour images and algorithms. The new edition features even more summary tables, highlighting the key points of differential immunophenotypic panels. A new, expanded introduction explains the basic principles of immunohistochemistry, and chapters have been updated to incorporate predictive/prognostic markers and the latest WHO classifications. All chapters are written by the same expert authors, providing a consistent, engaging style throughout and avoiding contradictory advice. An essential text for residents, this is also an extremely valuable resource for practitioners in anatomic pathology wishing to familiarise themselves with diagnostic markers at a quick glance.
Author: G. E. Rogers
Publisher: Springer Science & Business Media
ISBN: 9401197024
Category : Science
Languages : en
Pages : 494
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Book Description
Acknowledgements xi 1. Recent Trends in the Wool Industry and Some Long-Term Policy Issues 1 R. Richardson STRUCTURE AND FUNCTION OF THE HAIR FOLLICLE 2. Morphogenesis of the Hair Follicle during the Ontogeny of Human Skin 15 KA. Holbrook, C. Fisher, BA. Dale and R. Hartley 3. Specific Keratins and their Associated Proteins as Markers for Hair Follicle Differentiation 37 W.M O'Guin, D. Dhouailly, M. Manabe and T.-T. Sun 4. The Dermal Papilla and Maintenance of Hair Growth 51 R.F. Oliver and CA. B. lahoda 5. Special Biochemical Features of the Hair Follicle 69 G.E. Rogers, E.S. Kuczek, P.J. MacKinnon, R.B. Presland and M.J. Fietz KERATIN PROlEINS 6. Intermediate Filaments: Problems and Perspectives 87 R.D. Goldman and G.N. Dessev 7. Intermediate Filament Associated Protein of Epidermis 97 BA. Dale, KA. Resing, P.V. Haydock, P. Fieckman, C. Fisher and KA. Holbrook 8. Variations in the Proteins of Wool and Hair 117 R.C. Marshall and I.M. Gillespie 9. Protein Chains in Wool and Epidermal Keratin IF: Structural Features and Spatial Arrangement 127 J.F. Conway, R.D.B. Fraser, T.P. MacRae and DA. D. Pany 145 10. Amino Acid Sequences of Wool Keratin IF Proteins L.G. Sparrow, L.M. Dowling, V.Y. Loke and P.M. Strike 11. Structural Features of Keratin Intermediate Filaments 157 P.M. Steinert, D.R. Torchia and J.W.
Author: J. Gu
Publisher: Springer Science & Business Media
ISBN: 1461525322
Category : Science
Languages : en
Pages : 441
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Book Description
While advances in modem medicine largely parallel our understanding of morphology, discoveries in morphology are propelled by developments of new tools and means to visualize and measure tissue elements. The invention of dissecting, light, fluorescence and electron microscopes together with advances in labeling and staining techniques are among the stepping stones of morphological progress. Today, we are in an exciting new era when classical morphology is being combined with developments from other disciplines. The combination of morphology and immunology resulted in immunocytochemistry; morphology and molecular biology led to in situ hybridization and in situ PCR. Adding computer science to morphology gave birth to image analysis. Combining laser technology and the microsope evolved into confocal microscope. For more than a decade, modem morphology has continued to develop by merging with other disciplines at a rate that is still gathering momentum, providing exciting and dynamic new frontiers for other biological fields. "Modem Methods in Analytical Morphology," based largely on the "First International Workshop on Modem Methods in Analytical Histochemistry, "is an updated review of the current trends in the field. It covers an extensive array of new technical developments in major disciplines of modem morphology. The authors are not only leaders in their fields but also have extensive "hands on" experience with "bench work. " Their chapters are written in a comprehensive manner including discussion of both theoretical considerations and practical applications to give the readers a broad view of the topics covered.
Author: Manjul Tiwari
Publisher: CRC Press
ISBN: 1000819124
Category : Medical
Languages : en
Pages : 98
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Book Description
Cancer may be regarded as a group of diseases characterized by an (i) abnormal growth of cells (ii) ability to invade adjacent tissue and even distant organs and(iii) the eventual death of the affected patient if the tumor has progressed beyond that stage when it can be successfully removed.
