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Author: Kerry Alison Wekelo
Publisher:
ISBN: 9781937985783
Category : Business & Economics
Languages : en
Pages : 194
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Book Description
Culture Infusion is your guide for improving corporate culture and motivating your employees to perform at their highest capacity. Culture Infusion is for leaders and aspiring leaders who want to build a legacy, shift perspectives, and lead by example so others are inspired and driven to be their best selves. Whether you are a top-level executive or lead a team, you will find valuable insights in this book on how to create and maintain a sought-after workplace. You'll learn how to infuse a culture of holistic wellness into all aspects of your organization, from your people to your programs, and how you must thrive personally in order to lead others. Actualize Consulting learned firsthand that effective cultural change starts on a personal, individual level. They spent years building a strong foundation to improve corporate culture, and they now understand that happy employees lead to happy clients. As Managing Director of Human Resources and Operations for Actualize Consulting, author Kerry Alison Wekelo brings us a front-row seat perspective on her experiences, blending her corporate knowledge with her mindful wisdom. Culture Infusion provides nine easy, actionable principles to help you develop a customized game plan to improve your corporate culture and catapult your team to success. You'll discover key tips and tricks such as the three A's (Accountability, Acumen, Aspiration) that will aid in goal setting and performance reviews, and the 3P Method (Pause to Pivot to a Positive) that will change how you view every challenge and lead you to communicate more effectively.
Author: Kerry Alison Wekelo
Publisher:
ISBN: 9781937985783
Category : Business & Economics
Languages : en
Pages : 194
Get Book Here
Book Description
Culture Infusion is your guide for improving corporate culture and motivating your employees to perform at their highest capacity. Culture Infusion is for leaders and aspiring leaders who want to build a legacy, shift perspectives, and lead by example so others are inspired and driven to be their best selves. Whether you are a top-level executive or lead a team, you will find valuable insights in this book on how to create and maintain a sought-after workplace. You'll learn how to infuse a culture of holistic wellness into all aspects of your organization, from your people to your programs, and how you must thrive personally in order to lead others. Actualize Consulting learned firsthand that effective cultural change starts on a personal, individual level. They spent years building a strong foundation to improve corporate culture, and they now understand that happy employees lead to happy clients. As Managing Director of Human Resources and Operations for Actualize Consulting, author Kerry Alison Wekelo brings us a front-row seat perspective on her experiences, blending her corporate knowledge with her mindful wisdom. Culture Infusion provides nine easy, actionable principles to help you develop a customized game plan to improve your corporate culture and catapult your team to success. You'll discover key tips and tricks such as the three A's (Accountability, Acumen, Aspiration) that will aid in goal setting and performance reviews, and the 3P Method (Pause to Pivot to a Positive) that will change how you view every challenge and lead you to communicate more effectively.
Author: New Jersey Agricultural Experiment Station
Publisher:
ISBN:
Category : Agriculture
Languages : en
Pages : 862
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Book Description
Includes report of the New Jersey Agricultural College Experiment Station.
Author: University of Pennsylvania. Zoological Laboratory
Publisher:
ISBN:
Category :
Languages : en
Pages : 664
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Book Description
Author:
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 812
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Book Description
Vols. 17, 21-105 contain Annual reports of the Marine Biological Laboratory for 1907/08-1952.
Author: United States. Department of the Army
Publisher:
ISBN:
Category :
Languages : en
Pages : 454
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Book Description
Author: University of Adelaide
Publisher:
ISBN:
Category :
Languages : en
Pages : 616
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Book Description
Reprints.
Author: Iowa Agriculture and Home Economics Experiment Station
Publisher:
ISBN:
Category : Agricultural chemistry
Languages : en
Pages : 1044
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Book Description
Author: Paul Kindstedt
Publisher: Chelsea Green Publishing
ISBN: 1603584129
Category : Cooking
Languages : en
Pages : 275
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Book Description
Behind every traditional type of cheese there is a fascinating story. By examining the role of the cheesemaker throughout world history and by understanding a few basic principles of cheese science and technology, we can see how different cheeses have been shaped by and tailored to their surrounding environment, as well as defined by their social and cultural context. Cheese and Culture endeavors to advance our appreciation of cheese origins by viewing human history through the eyes of a cheese scientist. There is also a larger story to be told, a grand narrative that binds all cheeses together into a single history that started with the discovery of cheese making and that is still unfolding to this day. This book reconstructs that 9000-year story based on the often fragmentary information that we have available. Cheese and Culture embarks on a journey that begins in the Neolithic Age and winds its way through the ensuing centuries to the present. This tour through cheese history intersects with some of the pivotal periods in human prehistory and ancient, classical, medieval, renaissance, and modern history that have shaped western civilization, for these periods also shaped the lives of cheesemakers and the diverse cheeses that they developed. The book offers a useful lens through which to view our twenty-first century attitudes toward cheese that we have inherited from our past, and our attitudes about the food system more broadly. This refreshingly original book will appeal to anyone who loves history, food, and especially good cheese.
Author:
Publisher:
ISBN:
Category : Electronic journals
Languages : en
Pages : 554
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Book Description
Author: Ulrike Koehl
Publisher: Frontiers Media SA
ISBN: 2889456633
Category : Immunologic diseases. Allergy
Languages : en
Pages : 407
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Book Description
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.
