Cox Proportional Hazards Models for Modeling the Time to Onset of Decompression Sickness in Hypobaric Environments PDF Download
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Author: Laura A. Thompson
Publisher:
ISBN:
Category : Atmospheric pressure
Languages : en
Pages : 52
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Book Description
Author: Laura A. Thompson
Publisher:
ISBN:
Category : Atmospheric pressure
Languages : en
Pages : 52
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Author: National Aeronautics and Space Administration (NASA)
Publisher: Createspace Independent Publishing Platform
ISBN: 9781720454083
Category :
Languages : en
Pages : 50
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Book Description
In this paper we fit Cox proportional hazards models to a subset of data from the Hypobaric Decompression Sickness Databank. The data bank contains records on the time to decompression sickness (DCS) and venous gas emboli (VGE) for over 130,000 person-exposures to high altitude in chamber tests. The subset we use contains 1,321 records, with 87% censoring, and has the most recent experimental tests on DCS made available from Johnson Space Center. We build on previous analyses of this data set by considering more expanded models and more detailed model assessments specific to the Cox model. Our model - which is stratified on the quartiles of the final ambient pressure at altitude - includes the final ambient pressure at altitude as a nonlinear continuous predictor, the computed tissue partial pressure of nitrogen at altitude, and whether exercise was done at altitude. We conduct various assessments of our model, many of which are recently developed in the statistical literature, and conclude where the model needs improvement. We consider the addition of frailties to the stratified Cox model, but found that no significant gain was attained above a model that does not include frailties. Finally, we validate some of the models that we fit.Thompson, Laura A. and Chhikara, Raj S. and Conkin, JohnnyJohnson Space CenterDECOMPRESSION SICKNESS; EXTRAVEHICULAR ACTIVITY; DATA BASES; PARTIAL PRESSURE; HIGH ALTITUDE TESTS; HAZARDS; QUARTILES; PRESSURE; PHYSICAL EXERCISE; NONLINEARITY; NITROGEN; EXPOSURE; ALTITUDE SIMULATION; AEROEMBOLISM
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1792
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Author: Michael R. Barratt
Publisher: Springer Science & Business Media
ISBN: 0387681647
Category : Medical
Languages : en
Pages : 592
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Book Description
Over the years, a large body of knowledge has developed regarding the ways in which space flight affects the health of the personnel involved. Now, for the first time, this clinical knowledge on how to diagnose and treat conditions that either develop during a mission or because of a mission has been compiled by Drs. Michael Barratt and Sam L. Pool of the NASA/Johnson Space Center. Complete with detailed information on the physiological and psychological affects of space flight as well as how to diagnose and treat everything from dental concerns to decompression to dermatological problems encountered, this text is a must have for all those associated with aerospace medicine.
Author: Linda Ed Weaver
Publisher:
ISBN: 9781930536739
Category : Medical
Languages : en
Pages : 415
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Book Description
The Undersea and Hyperbaric Medical Society (UHMS) is an international, non-profit organization serving over 2,400 members from more than 50 countries. The UHMS is the primary source of scientific information for diving and hyperbaric medicine physiology worldwide, the breadth of which is illustrated in the triennial report, Hyperbaric Oxygen Therapy Indications. With leading experts authoring chapters in their respective fields, this publication continues to provide the most current and up to date guidance and support for scientists and practitioners of hyperbaric oxygen therapy. Hyperbaric Oxygen Therapy Indications, currently in its thirteenth edition, has grown in size and depth to reflect the evolution of the literature on the approved use of hyperbarics from both a clinical practice standpoint and insurance coverage perspective. To date, the committee recognizes fourteen indications, including the new indication, idiopathic sudden sensorineural hearing loss. Additionally, this book continues to be used by the Centers for Medicare and Medicaid Services and other third party insurance carriers in determining payment for HBO2 services.
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2540
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Author: Richard E. Moon
Publisher:
ISBN: 9781947239166
Category : Medical
Languages : en
Pages : 0
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Book Description
Since its first appearance in 1977, the UHMS Hyperbaric Oxygen Therapy Indications has served as a guide for practitioners and scientists interested in hyperbaric and undersea medicine.
Author: Randall W. Davis
Publisher: Springer Nature
ISBN: 331998280X
Category : Science
Languages : en
Pages : 303
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Book Description
This comprehensive book provides new insights into the morphological, metabolic, thermoregulatory, locomotory, diving, sensory, feeding, and sleep adaptations of Cetacea (whales and dolphins), Pinnipedia (seals, sea lions and walrus), Sirenia (manatees and dugongs) and sea otters for an aquatic life. Each chapter reviews the discoveries from previous studies and integrates recent research using new techniques and technology. Readers will gain an understanding of the remarkable adaptations that enable marine mammals to spend all or most of their lives at sea, often while hunting prey at depth.
Author: Wen-Ta Chiu
Publisher: Springer Science & Business Media
ISBN: 3211782052
Category : Medical
Languages : en
Pages : 166
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Book Description
International experts present in this volume advances in reconstructive neurosurgery focusing on the fields of neurotrauma and neurodegenerative disorders. The highlights include building an international strategy for risk reduction, documentating an multidisciplinary approach towards restoration of function in paraplegic spinal cord-injured patients, describing a new approach for statistical analysis in traumatic brain injury trials, describing blood flow changes in diffuse brain injury, discussing rehabilitation programs in Germany following acute brain injury, describing research data form Taiwan on neurotrauma, showing the neuropsychiatric effects from deep brain stimuation fro ovement disorders, difining the role played by imanging for deep brain stimulation targeting in mental illness, using radiosurgery in decompresssion in the treatment of trigeminal neuralgia, describing the development of radiosurgery from brain to the spine, listing new transgenic animal models of Parkinson's disease, discussing gene therapy for neuropathic pain and Parkinson's disease, and finally, discussing constrained-induced movement therapy fro stroke patients, and endovascular therapy for cerebrovenous disorders.
Author: Barry S. Levy
Publisher: American Public Health Association
ISBN: 9780875530437
Category : Medical
Languages : en
Pages : 628
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Book Description
