Controversies in the Management of Liver Metastases PDF Download
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Author: Thomas M. van Gulik
Publisher:
ISBN: 9783805590471
Category :
Languages : en
Pages : 0
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Book Description
While considerable progress has been made in both surgical treatment of liver metastases and neoadjuvant or postoperative chemotherapy, decision making has become more complex. The definition of accurate measures is very difficult because there exists no consensus regarding pre- or postoperative predictors of survival in patients undergoing liver resection: Even though PET is well established in the diagnosis of colorectal cancer and its metastases, it is unclear whether a combination of imaging modalities will be of additional value. Neoadjuvant strategies are very efficient in downsizing metastasis, but they at the same time reduce functional liver reserve due to chemotherapy-induced liver injury. The advantages and disadvantages of the 'liver first' approach are likewise discussed, as are controversial issues in the use of portal vein embolization and radiofrequency ablation versus resection. Even though the main focus of this publication is on colorectal liver metastases, other primary cancers also receive some attention: Papers on resection of liver metastases combined with primary cancers conclude the discussions. This collection of papers provides valuable information on the many issues connected with the management of liver metastases, both colorectal and non-colorectal. Surgeons confronted with the question as to the best treatment strategy will find it a very helpful aid in their decision process.
Author: Thomas M. van Gulik
Publisher:
ISBN: 9783805590471
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
While considerable progress has been made in both surgical treatment of liver metastases and neoadjuvant or postoperative chemotherapy, decision making has become more complex. The definition of accurate measures is very difficult because there exists no consensus regarding pre- or postoperative predictors of survival in patients undergoing liver resection: Even though PET is well established in the diagnosis of colorectal cancer and its metastases, it is unclear whether a combination of imaging modalities will be of additional value. Neoadjuvant strategies are very efficient in downsizing metastasis, but they at the same time reduce functional liver reserve due to chemotherapy-induced liver injury. The advantages and disadvantages of the 'liver first' approach are likewise discussed, as are controversial issues in the use of portal vein embolization and radiofrequency ablation versus resection. Even though the main focus of this publication is on colorectal liver metastases, other primary cancers also receive some attention: Papers on resection of liver metastases combined with primary cancers conclude the discussions. This collection of papers provides valuable information on the many issues connected with the management of liver metastases, both colorectal and non-colorectal. Surgeons confronted with the question as to the best treatment strategy will find it a very helpful aid in their decision process.
Author: T. Wiegel
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805576900
Category : Science
Languages : en
Pages : 132
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Book Description
This volume discusses diagnostic and therapeutic strategies including current controversial issues in the management of gastrointestinal tumors. Special emphasis is given to rectal and pancreatic cancer. The first part presents the latest diagnostic developments for rectal cancer with a focus on the role of preoperative radiotherapy and radio-chemotherapy. Also considered is the surgical technique of total mesorectal excision. Recurrent rectal cancer is another important issue under discussion. A large section of the book is devoted to the diagnosis and interdisciplinary treatment of pancreatic cancer. Controversies regarding the role of adjuvant radiochemotherapy are presented in detail. The final part is dedicated to the treatment of liver metastases and describes the results of surgical resection and new therapeutic approaches such as in situ ablation and radiosurgery. Offering an interdisciplinary perspective on gastrointestinal tumor therapy, this book will be of great value to surgeons and radiation oncologists. It will also be appreciated by other clinicians involved in the care of patients with gastrointestinal tumors.
Author: Mauro Monteiro Correia
Publisher: Springer Nature
ISBN: 3030254860
Category : Medical
Languages : en
Pages : 597
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Book Description
Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.
Author: Katherine A. Morgan
Publisher: Springer
ISBN: 3319162055
Category : Medical
Languages : en
Pages : 220
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Book Description
Over the past decade, major advances have occurred in the management of the many fields of cancer treatment encountered by the general surgeon. These developments have evolved from improved understanding of disease biology, high level clinical outcomes studies, as well as translational research with new available therapies. These advances have brought major changes to cancer care and have surfaced new dilemmas in clinical decision-making. Modern cancer management requires an understanding of the current status of a diverse array of oncologic diseases. Current Controversies in Cancer Care for the Surgeon provides a comprehensive update on the management of various cancers as interpreted by recognized experts in the field. In addition, each chapter will focus on current controversies and areas of advance. The text is designed to assist the practicing surgeon in achieving optimal management of encountered oncologic problems. Such an inclusive text will be invaluable resource for clinical surgeons, surgeons in training, students and researchers.
Author: Tim F. Greten
Publisher: Springer
ISBN: 9783319879116
Category : Medical
Languages : en
Pages : 0
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Book Description
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 111900084X
Category : Medical
Languages : en
Pages : 2004
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Dario Ribero
Publisher: Nova Science Publishers
ISBN: 9781634834889
Category : Bile ducts
Languages : en
Pages : 0
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Book Description
Cholangiocarcinoma is a heterogeneous group of neoplasms, which has a rising worldwide incidence. Therefore, it is now a major cause of cancer mortality. Diagnosis, staging, treatment approaches and outcomes differ significantly based on the location of the tumor. Given the challenges of remaining up-to-date in a rapidly expanding field, the aim of this monograph is to provide a comprehensive, fully referenced presentation of the state-of-the-art medical and surgical aspects relevant to the management of cholangiocarcinoma divided by the site of origin (i.e. intrahepatic, hilar and distal). The division of the book into these sections reflects the biological and clinical differences between these tumor types and will permit the authors to address the diagnostic, interventional or treatment issues specific to each tumor type. By presenting all medical and surgical aspects of cholangiocarcinoma in a systematic manner, this monograph will be a ready-to-use instrument for those interested in cholangiocarcinoma, including practicing physicians, residents, fellows and specialists. A list of 66 world-renowned experts contributed to the book, offering the readers the unique opportunity to have a broad perspective on these diseases, practical indications on patient selection and treatment that can be easily applied to both Eastern and Western clinical settings.
Author: Joseph Ragaz
Publisher: Springer Science & Business Media
ISBN: 3642826717
Category : Medical
Languages : en
Pages : 172
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Book Description
Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.
Author: Tim Cross
Publisher: Springer
ISBN: 3319922165
Category : Medical
Languages : en
Pages : 312
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Book Description
This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery
Author: Quyen D Chu
Publisher: Beaux Books Publishing, LLC
ISBN: 0997772182
Category : Medical
Languages : en
Pages : 1352
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Book Description
This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.
