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Author: E. S. Nuwayser
Publisher:
ISBN:
Category :
Languages : en
Pages : 177
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Book Description
The overall objective of Phase II is to bring the prototype sustained release arthropod repellent formulation developed in Phase I to large scale manufacturing stage. This Phase II report details the work conducted during the past eight months for the development of a 12 hour sustained action arthropod repellent formulation. The work culminated in the development of BIOTEK sustained action Formulation 50I which meets virtually all the criteria and requirements of the contract; and the manufacture and submission to USAMRDC of 2,600 samples of the formulation in camouflaged and non-camouflaged labelled containers for evaluation. In addition an EPA Registration Package, a User Training Manual, and a Technical Data Package were prepared and submitted to the Army. Extensive evaluation of BIOTEK Formulation 50I was conducted: 1) in vitro on weanling pig skin 2) in vivo on human volunteers under controlled environments against a variety of mosquitoes; 3) in vivo on human volunteers in field test in Vero Bleach Florida against a variety of mosquitoes; 4) in rabbits against a variety of arthropods; 5) in rabbits to determine toxicity; and 6) for compatability with military materials. Troop Acceptability of the formulation was also determined on human volunteers of military age.
Author: E. S. Nuwayser
Publisher:
ISBN:
Category :
Languages : en
Pages : 177
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Book Description
The overall objective of Phase II is to bring the prototype sustained release arthropod repellent formulation developed in Phase I to large scale manufacturing stage. This Phase II report details the work conducted during the past eight months for the development of a 12 hour sustained action arthropod repellent formulation. The work culminated in the development of BIOTEK sustained action Formulation 50I which meets virtually all the criteria and requirements of the contract; and the manufacture and submission to USAMRDC of 2,600 samples of the formulation in camouflaged and non-camouflaged labelled containers for evaluation. In addition an EPA Registration Package, a User Training Manual, and a Technical Data Package were prepared and submitted to the Army. Extensive evaluation of BIOTEK Formulation 50I was conducted: 1) in vitro on weanling pig skin 2) in vivo on human volunteers under controlled environments against a variety of mosquitoes; 3) in vivo on human volunteers in field test in Vero Bleach Florida against a variety of mosquitoes; 4) in rabbits against a variety of arthropods; 5) in rabbits to determine toxicity; and 6) for compatability with military materials. Troop Acceptability of the formulation was also determined on human volunteers of military age.
Author: Neil A. Randen
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Book Description
An improved controlled-release arthropod repellent formulation for topical application to a person's exposed skin areas that provides extended protection against biting arthropods, which is safe and agreeable to use, which is more compatible with other current and projected military materials and systems than the Army's current 75% N, N-diethyl-m-toluamide (DEET) in alcohol formulation and which compiles with the registration requirements of the Environmental Protection Agency (EPA) has been developed. The Phase I formulation containing 30% DEET and an acrylate polymer served as the starting point for the refinement and development in Phase II. The final Phase II submission contained 35% DEET and the acrylate polymer. This formulation provided 95% repellency against Aedes aegypti mosquitoes for 14-15 hours, 10-11 hours and 14015 hours when evaluated in the constant high humidity, the variable high humidity and the basic hot climatic conditions using a modified standard mosquito repellency test method (ASTM:E951-83).
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 81
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Book Description
An improved controlled-release arthropod repellent formulation for topical application to a person's exposed skin areas that provides extended protection against biting arthropods, which is safe and agreeable to use, which is more compatible with other and projected military materials and systems than the Army's current 75% N, N-diethyl m-toluamide (DEET) in alcohol formulation and which complies with the registration requirements of the Environmental Protection Agency (EPA) has been developed in Phase I and Phase II of this contract. The Phase II repellent containing 35% DEET and an acrylate polymer has been refined to improve its low temperature stability. This new Phase III formulation was the basis for the EPA insect repellent registration submitted on May 27, 1987. The acrylate polymer used in the repellent formulation had to be scaled-up first. A few problems were encountered but they were overcome and the polymer was prepared successfully in the required quantity. A technical data package covering the production processes, quality control and product specification was written for the Insect/Arthropod Repellent Lotion.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
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Book Description
Between 1 May and 15 August 1986 field tests involving human subjects and natural mosquito populations were conducted at the Florida Medical Entomology Laboratory, University of Florida IFAS Field Station in Vero Beach, Florida on 3 slow release insect repellent formulations of deet (N, N-diethyl-m-tolumaide developed by BIOTEK, Inc. of Woburn, Massachusetts. These field tests were funded by a BIOTEK subcontract from a U.S. Army Grant awarded for the development and testing of a slow release insect repellent formulations. The work scope for these field tests included these objectives: 1) Preparation of protocol for field tests of BIOTEK's sustained action arthropod repellent utilizing Aedes taeniorhynchus and Anopheles quadrimaculatus; 2) Recruitment of subjects and personnel for the field tests; 3) To conduct pre-test sampling of mosquito populations at potential field sites and then decide on the appropriate site for each of the field tests; and 4) To conduct tests with humans of three (3) BIOTEK slow release arthropod repellent formulations and a deet standard utilizing field populations of Aedes Taeniorhynchus and Anopheles quadrimaculatus during the interval 30 June to 18 August 1986.
Author: E. S. Nuwayser
Publisher:
ISBN:
Category :
Languages : en
Pages : 158
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Book Description
BIOTEK, Inc. has developed an arthropod repellent formulation containing N, N, -diethyl-m-toluamide (Deet) for topical application to exposed skin which will provide protection for a duration of 12 hours. This has been achieved by formulating the active ingredient, Deet, with a proprietary blend of silica gel, a lotion base, and alcohol. The formulation is non-toxic, is cosmetically acceptable, is more compatible with military materials than the current in-use formulation, and complies with EPA specifications. In vitro testing of our formulation in a Reifenrath permeation/evaporation cell using weanling pig skin shows an evaporation rate greater than the minimum effective evaporation rate described by the Request for Proposal for a period of 22 hours. Under standard clinical test conditions of moderate temperature and humidity, the formulation provided 100% protection against Aedes aegypti mosquitoes for at least 12 hours, at an applied formulation dose of 2 mg per square centimeter. It is expected that protection may be maintained beyond 12 hours since complete protection was evident at 12 hours when testing was concluded.
Author:
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 566
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Book Description
Author:
Publisher:
ISBN:
Category : Mosquitoes
Languages : en
Pages : 780
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Book Description
Author: Joel Coats
Publisher: Academic Press
ISBN: 0323854125
Category : Nature
Languages : en
Pages : 360
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Book Description
Advances in Arthropod Repellents offers the most current knowledge on arthropod repellents. This area of study is quickly evolving as mosquito- and tick-borne diseases become more prevalent worldwide. Written by global arthropod repellent experts, this book begins by delving into molecule discovery and assay development that is followed by the latest research and investigations of repellent developments and effects. The book then offers readers a look into the global field, semi-field, and laboratory trials using various insect repellents, ranging from Africa, Australia, Europe, South America and the United States. Lastly, it examines the future of spatial repellents and expert insight. This book is a valuable resource for entomologists and vector control researchers and practitioners. Public health officials and developers in private pest control companies, as well as readers in academia will find this a useful resource to learn the latest information available on controlling the spread of arthropod-borne diseases with repellents. Discusses recent progress on understanding how insect repellents work, as well as modern methods for finding new molecules and formulations Edited by a team whose expertise includes cutting-edge insect repellent research and development Serves as a reference and resource that will be useful to a wide variety of professionals, particularly those in public health and vector control
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1844
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Book Description
Author: Paul S. Auerbach
Publisher: Elsevier Health Sciences
ISBN: 0323396097
Category : Medical
Languages : en
Pages : 3097
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Book Description
Now in its 7th edition, Auerbach’s Wilderness Medicine continues to help you quickly and decisively manage medical emergencies encountered in any wilderness or other austere setting! World-renowned authority Dr. Paul Auerbach and 2 new associate editors have assembled a team of experts to offer proven, practical, visual guidance for effectively diagnosing and treating the full range of issues that can occur in situations where time and resources are scarce. This indispensable resource equips physicians, nurses, advanced practice providers, first responders, and rescuers with the essential knowledge and skills to effectively address and prevent injuries and illnesses – no matter where they happen! Brand-new 2-volume format ensures all content is available in print and online to provide you easy access. Face any medical challenge in the wilderness with expert guidance from hundreds of outstanding world experts edited by Dr. Auerbach and 2 new associate editors, Drs.Tracy Cushing and N. Stuart Harris New and expanded chapters with hundreds of new photos and illustrative drawings help increase your visual understanding of the material Acquire the knowledge and skills you need with revised chapters providing expanded discussions of high-altitude medicine, improvisation, technical rescue, telemedicine, ultrasound, and wilderness medicine education Ten new chapters cover Acute High-Altitude Medicine and Pathophysiology; High Altitude and Pre-Existing Medical Conditions; Cycles, Snowmobiles, and other Wilderness Conveyances; Medical Wilderness Adventure Races (MedWAR); Canyoneering and Canyon Medicine; Evidence-Based Wilderness Medicine; National Park Service Medicine; Genomics and Personalized Wilderness Medicine; Forestry; and Earth Sciences 30+ Expert Consult online videos cover survival tips, procedural demonstrations, and detailed explanations of diseases and incidents Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices
