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Author: Shari Marie Kaiser
Publisher:
ISBN: 9781109911923
Category :
Languages : en
Pages : 129
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Book Description
Retroviruses are undoubtedly one of the most elegant entities of the world. With modest genomes and intricate architecture, retroviruses are able to invade a species, establish a domicile, evade the immune system and rapidly evolve to successfully replicate in a specialized niche of the host. To establish a productive infection, retroviruses heavily rely on the host factors to successfully complete their replication cycle. Yet, as the retrovirus directs coordination and utilization of various host proteins for its own benefit, it simultaneously must evade interactions with the host antiviral and immune proteins that are in place to limit virus replication.
Author: Shari Marie Kaiser
Publisher:
ISBN: 9781109911923
Category :
Languages : en
Pages : 129
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Book Description
Retroviruses are undoubtedly one of the most elegant entities of the world. With modest genomes and intricate architecture, retroviruses are able to invade a species, establish a domicile, evade the immune system and rapidly evolve to successfully replicate in a specialized niche of the host. To establish a productive infection, retroviruses heavily rely on the host factors to successfully complete their replication cycle. Yet, as the retrovirus directs coordination and utilization of various host proteins for its own benefit, it simultaneously must evade interactions with the host antiviral and immune proteins that are in place to limit virus replication.
Author: John A.T. Young
Publisher: Springer Science & Business Media
ISBN: 364219012X
Category : Medical
Languages : en
Pages : 250
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Book Description
The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.
Author: Leslie Parent
Publisher: Academic Press
ISBN: 0128111933
Category : Science
Languages : en
Pages : 622
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Book Description
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems
Author: Bryan Cullen
Publisher: Oxford University Press
ISBN: 9780199633821
Category : Gene Expression Regulation.
Languages : en
Pages : 220
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Book Description
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author: John A T Young
Publisher:
ISBN: 9783642190131
Category :
Languages : en
Pages : 256
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Book Description
Author: Amit Sharma
Publisher:
ISBN:
Category :
Languages : en
Pages : 282
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Book Description
Abstract: Retroviruses are etiological agents of several human and animal immunosuppressive disorders. They are associated with certain types of cancer and are useful tools for gene transfer applications. All retroviruses encode a single primary transcript that encodes a complex proteome. The RNA genome is reverse transcribed into DNA, integrated into the host genome, and uses host cell factors to transcribe, process and traffic transcripts that encode viral proteins and act as virion precursor RNA, which is packaged into the progeny virions. The functionality of retroviral RNA is governed by ribonucleoprotein (RNP) complexes formed by host RNA helicases and other RNA-binding proteins. The 5' leader of retroviral RNA undergoes alternative inter- and intra-molecular RNA-RNA and RNA-protein interactions to complete multiple steps of the viral life cycle. Retroviruses do not encode any RNA helicases and are dependent on host enzymes and RNA chaperones. Several members of the host RNA helicase superfamily are necessary for progressive steps during the retroviral replication. RNA helicase A (RHA) interacts with the redundant structural elements in the 5' untranslated region (UTR) of retroviral and selected cellular mRNAs and this interaction is necessary to facilitate polyribosome formation and productive protein synthesis. The research presented in this dissertation has: (1) outlined the approaches to define the function of host RNA helicases in viral replication, (2) determined that the ATPase-dependent helicase function of RHA is necessary for HIV-1 translation, (3) determined that the RHA chaperone function promotes efficient morphogenesis of infectious HIV-1, and (4) identified a novel viral strategy to sustain HIV-1 proteins synthesis during downregulation of eIF4E-dependent translation initiation by HIV-1. In summary, the functionality of HIV-1 RNA is governed in part by RNP complexes formed by host RNA-binding proteins. Interaction with these host factors facilitate RNA:RNA and RNA:protein interactions thereby making the HIV-1 RNPs dynamic in nature. Dynamic changes in the RNP complexes are necessary for efficient viral protein synthesis, trafficking and morphogenesis of progeny virions that productively infect host lymphocytes to complete the viral life cycle.
Author: Nouri Neamati
Publisher: John Wiley & Sons
ISBN: 1118015363
Category : Science
Languages : en
Pages : 710
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Book Description
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Author: Ann Arvin
Publisher: Cambridge University Press
ISBN: 1139461648
Category : Medical
Languages : en
Pages : 1325
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Book Description
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author: Paul L. Bartel
Publisher: Oxford University Press, USA
ISBN: 9780195109382
Category : Carrier proteins
Languages : en
Pages : 362
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Book Description
This volume, part of the Advances in Molecular Biology series, presents work by pioneers in the field and is the first publication devoted solely to the yeast two-hybrid system. It includes detailed protocols, practical advice on troubleshooting, and suggestions for future development. In addition, it illustrates how to construct an activation domain hybrid library, how to identify mutations that disrupt an interaction, and how to use the system in mammalian cells. Many of the contributors have developed new applications and variations of the technique.
Author: Thomas J. Hope
Publisher:
ISBN: 9781461496106
Category : AIDS (Disease)
Languages : en
Pages :
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Book Description
