Comparative Diagnostic Pharmacology

Comparative Diagnostic Pharmacology PDF Author: C.P. Coyne
Publisher: John Wiley & Sons
ISBN: 0470344296
Category : Medical
Languages : en
Pages : 935

Get Book Here

Book Description
Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models is the first evidence-based reference text devoted exclusively to the subject of applying pharmaceutical and biopharmaceutical agents as diagnostic probes in clinical medicine and investigative research.This unique and groundbreaking book is a versatile guide for clinicians and researchers interested in using pharmacologic agents to: Diagnose disease Assess physiological processes Identify the appropriateness of a therapeutic agent Determine appropriate dosing for therapeutic use. Extensively referenced and organized by major body systems, individual topics are listed in an evidence-based format according to specific disease processes or physiological processes of interest. Each entry also includes information on the mechanism of action, administration, and diagnostic interpretation. Descriptions have been provided for the application of diagnostic pharmaceuticals to assess a wide spectrum of diseases and physiological processes relevant to the fields of veterinary and human medicine. Comparative Diagnostic Pharmacology is useful not merely for pharmaceutical-oriented research investigations, but it will also prove invaluable for the monitoring and evaluation of physiological responses and disease processes in animal models.

Comparative Diagnostic Pharmacology

Comparative Diagnostic Pharmacology PDF Author: C.P. Coyne
Publisher: John Wiley & Sons
ISBN: 0470344296
Category : Medical
Languages : en
Pages : 935

Get Book Here

Book Description
Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models is the first evidence-based reference text devoted exclusively to the subject of applying pharmaceutical and biopharmaceutical agents as diagnostic probes in clinical medicine and investigative research.This unique and groundbreaking book is a versatile guide for clinicians and researchers interested in using pharmacologic agents to: Diagnose disease Assess physiological processes Identify the appropriateness of a therapeutic agent Determine appropriate dosing for therapeutic use. Extensively referenced and organized by major body systems, individual topics are listed in an evidence-based format according to specific disease processes or physiological processes of interest. Each entry also includes information on the mechanism of action, administration, and diagnostic interpretation. Descriptions have been provided for the application of diagnostic pharmaceuticals to assess a wide spectrum of diseases and physiological processes relevant to the fields of veterinary and human medicine. Comparative Diagnostic Pharmacology is useful not merely for pharmaceutical-oriented research investigations, but it will also prove invaluable for the monitoring and evaluation of physiological responses and disease processes in animal models.

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide PDF Author: Agency for Health Care Research and Quality (U.S.)
Publisher: Government Printing Office
ISBN: 1587634236
Category : Medical
Languages : en
Pages : 236

Get Book Here

Book Description
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Improving Diagnosis in Health Care

Improving Diagnosis in Health Care PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309377722
Category : Medical
Languages : en
Pages : 473

Get Book Here

Book Description
Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

Handbook of Veterinary Pharmacology

Handbook of Veterinary Pharmacology PDF Author: Walter H. Hsu
Publisher: John Wiley & Sons
ISBN: 1118714164
Category : Medical
Languages : en
Pages : 564

Get Book Here

Book Description
Handbook of Veterinary Pharmacology is a clear and concise guide to pharmacology concepts and commonly used veterinary drugs. Providing a succinct overview of veterinary pharmacology, this book presents information in a user-friendly outline format to allow quick access to practical drug information. With chapters covering the basic principles, specific drugs, interactions, and legal considerations, Handbook of Veterinary Pharmacology offers up-to-date information on basic and clinical veterinary pharmacology. As an aid to student comprehension, simple line drawings depict the mechanisms of action and study questions with explanations are included at the end of each chapter. Appendices on withdrawal times for drugs in production animals and drug dosages in domestic species are a valuable tool, allowing quick decisions on drug therapy. Handbook of Veterinary Pharmacology is an indispensable text for veterinary students and practitioners.

The Prevention and Treatment of Missing Data in Clinical Trials

The Prevention and Treatment of Missing Data in Clinical Trials PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 030918651X
Category : Medical
Languages : en
Pages : 163

Get Book Here

Book Description
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Pharmacoepidemiology

Pharmacoepidemiology PDF Author: Brian L. Strom
Publisher: John Wiley & Sons
ISBN: 1119413419
Category : Medical
Languages : en
Pages : 1220

Get Book Here

Book Description
This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.

Veterinary Pharmacology and Therapeutics

Veterinary Pharmacology and Therapeutics PDF Author: Jim E. Riviere
Publisher: John Wiley & Sons
ISBN: 1118855884
Category : Medical
Languages : en
Pages : 3248

Get Book Here

Book Description
Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species. Provides current, detailed information on using drug therapies in all major domestic animal species Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine Includes extensive tables of pharmacokinetic data, products available, and dosage regimens Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology Includes access to a companion website with the figures from the book in PowerPoint

Oxford Handbook of Clinical Diagnosis

Oxford Handbook of Clinical Diagnosis PDF Author: Huw Llewelyn
Publisher: Oxford University Press, USA
ISBN: 019967986X
Category : Medical
Languages : en
Pages : 683

Get Book Here

Book Description
This handbook describes the diagnostic process clearly and logically, aiding medical students and others who wish to improve their diagnostic performance and to learn more about the diagnostic process.

Pharmacology for the Health Care Professions

Pharmacology for the Health Care Professions PDF Author: Christine M. Thorp
Publisher: John Wiley & Sons
ISBN: 9780470696903
Category : Science
Languages : en
Pages : 376

Get Book Here

Book Description
Pharmacology for the Health Care Professions is an accessible introduction to the pharmacology necessary for health care professionals training to be non-medical prescribers looking for an overview of the subject. The book covers the pharmacology necessary for accredited training programmes in non-medical prescribing and certification in access and supply of prescription-only medicines and will be useful as an ongoing reference for future use in practice. Opening with a general introduction to pharmacology as a science, the book goes on to explain what is meant by drugs and medicines and why pharmacology should be of relevance to health care professionals. The reader is presented with general principles of pharmacology followed by systemic pharmacology that covers the actions of important groups of drugs in common use to treat diseases and conditions of the cardiovascular, respiratory, endocrine, musculoskeletal, skin and central nervous systems. The physiology and pathophysiology relevant to the understanding of how these drugs work is included. Finally the book explores the law in relation to the sale, supply, administration and prescription of drugs and explains what is meant by non-medical prescribing. All aspects of non-medical prescribing are considered including the use of exemptions to the Medicines Act, patient group directions, supplementary prescribing and the development of independent prescribing for nurses and pharmacists. Pharmacology is explained in simple, easy to understand terms and the book avoids any unnecessary chemistry where possible. Case studies that are of particular relevance to health care professionals are used throughout to illustrate the importance of the pharmacology major body systems and pathologies and the potential problems of adverse drug reactions and drug-drug interactions.

Initial National Priorities for Comparative Effectiveness Research

Initial National Priorities for Comparative Effectiveness Research PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309138361
Category : Medical
Languages : en
Pages : 252

Get Book Here

Book Description
Clinical research presents health care providers with information on the natural history and clinical presentations of disease as well as diagnostic and treatment options. In today's healthcare system, patients, physicians, clinicians and family caregivers often lack the sufficient scientific data and evidence they need to determine the best course of treatment for the patients' medical conditions. Initial National Priorities for Comparative Effectiveness Research(CER) is designed to fill this knowledge gap by assisting patients and healthcare providers across diverse settings in making more informed decisions. In this 2009 report, the Institute of Medicine's Committee on Comparative Effectiveness Research Prioritization establishes a working definition of CER, develops a priority list of research topics, and identifies the necessary requirements to support a robust and sustainable CER enterprise. As part of the 2009 American Recovery and Reinvestment Act, Congress appropriated $1.1 billion in federal support of CER, reflecting legislators' belief that better decisions about the use of health care could improve the public's health and reduce the cost of care. The Committee on Comparative Effectiveness Research Prioritization was successful in preparing a list 100 top priority CER topics and 10 recommendations for best practices in the field.