Collective Behavior of Living Cells on Patterned Substrate PDF Download
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Author: Haosheng Wen
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Individual units of many biological systems can produce cooperative behaviors through direct interactions between individuals as well as interactions between the surrounding media and individuals. This cooperativity is characterized by amazing collective dynamical and structural behaviors at large scales. In this work, we use molecular dynamics simulations of a ring polymer model, to describe biological cells, to systematically investigate the collective behavior of disjoint semi-flexible cells and their dynamic assembly behavior. We particularly investigate the effect of cell motility, the areal density of the cells, and their interactions with the substrate on their collective behavior. Our results show that the collective behavior of cells strongly depends on an interplay among the driving force of cells, the strength of the circularly patterned substrate, and areal density. A rich phenomenology and dynamics of collective cells motion of cells is revealed from our simulations, including giant traveling bands, unidirectional vortices, and dynamic phase transitions from non-collective to collective behavior as a function of cells motility and areal density. Our study provides novel non-trivial insight into biological processes associated with cell motility, stiffness of the substrate, and cell areal density.
Author: Haosheng Wen
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Individual units of many biological systems can produce cooperative behaviors through direct interactions between individuals as well as interactions between the surrounding media and individuals. This cooperativity is characterized by amazing collective dynamical and structural behaviors at large scales. In this work, we use molecular dynamics simulations of a ring polymer model, to describe biological cells, to systematically investigate the collective behavior of disjoint semi-flexible cells and their dynamic assembly behavior. We particularly investigate the effect of cell motility, the areal density of the cells, and their interactions with the substrate on their collective behavior. Our results show that the collective behavior of cells strongly depends on an interplay among the driving force of cells, the strength of the circularly patterned substrate, and areal density. A rich phenomenology and dynamics of collective cells motion of cells is revealed from our simulations, including giant traveling bands, unidirectional vortices, and dynamic phase transitions from non-collective to collective behavior as a function of cells motility and areal density. Our study provides novel non-trivial insight into biological processes associated with cell motility, stiffness of the substrate, and cell areal density.
Author:
Publisher: Academic Press
ISBN: 9780124167421
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
This new volume of Methods in Cell Biology looks at micropatterning in cell biology and includes chapters on protein photo-patterning on PEG with benzophenone, laser-directed cell printing and dip pen nanolithography. The cutting-edge material in this comprehensive collection is intended to guide researchers for years to come.
Author: Leif C. Andersson
Publisher:
ISBN:
Category : Nature
Languages : en
Pages : 280
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Book Description
Author: Carsten Beta
Publisher: Springer Nature
ISBN: 1071640232
Category :
Languages : en
Pages : 225
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Book Description
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Nicolas Giuseppone
Publisher: John Wiley & Sons
ISBN: 3527821988
Category : Science
Languages : en
Pages : 448
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Book Description
A must-have resource that covers everything from out-of-equilibrium chemical systems and materials to dissipative self-assemblies Out-of-Equilibrium Supramolecular Systems and Materials presents a comprehensive overview of the synthetic approaches that use supramolecular bonds in various out-of-thermodynamic equilibrium situations. With contributions from noted experts on the topic, the text contains information on the design of dissipative self-assemblies that maintain their structures when fueled by an external source of energy. The contributors also examine molecules and nanoscale objects and materials that can produce mechanical work based on molecular machines. Additionally, the book explores non-equilibrium supramolecular polymers that can be trapped in kinetically stable states, as well as out-of-equilibrium chemical systems and oscillators that are important to understand the emergence of complex behaviors and, in particular, the origin of life. This important book: Offers comprehensive coverage of fields from design of dissipative self-assemblies to non-equilibrium supramolecular polymers Presents information on a highly emerging and interdisciplinary topic Includes contributions from internationally renowned scientists Written for chemists, physical chemists, biochemists, material scientists, Out-of-Equilibrium Supramolecular Systems and Materials is an indispensable resource written by top scientists in the field.
Author: Mark E. Furman
Publisher: CRC Press
ISBN: 142004043X
Category : Medical
Languages : en
Pages : 372
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Book Description
How do brain, mind, matter, and energy interact? Can we create a comprehensive model of the mind and brain, their interactions, and their influences? Synthesizing research from neuroscience, physics, biology, systems science, information science, psychology, and the cognitive sciences, The Neurophysics of Human Behavior advances a unified theory of
Author: Roland Kaunas
Publisher: CRC Press
ISBN: 1466553820
Category : Medical
Languages : en
Pages : 370
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Book Description
Explores a Range of Multiscale Biomechanics/Mechanobiology ConceptsCell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forc
Author: Roger T. Hanlon
Publisher: Cambridge University Press
ISBN: 0521897858
Category : Science
Languages : en
Pages : 383
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Book Description
A fully updated overview of the causation, function, development and evolution of cephalopod behaviour, richly illustrated in full colour.
Author: Misturu Akashi
Publisher: Springer
ISBN: 4431551395
Category : Medical
Languages : en
Pages : 271
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Book Description
This book is the first to summarize new technologies for engineered cell manipulation. The contents focus on control of cellular functions by nanomaterials and control of three-dimensional cell–cell interactions. Control of cellular functions is important for cell differentiation, maturation, and activation, which generally are controlled by the addition of soluble cytokines or growth factors into cell culture dishes. Target antigen molecules can be efficiently delivered to the cytosol of the dendritic cells using the nanoparticle technique described here, and cellular functions such as dendritic cell maturation can be controlled easily and with precision. This book describes basic preparation of the nanoparticles, activation control of dendritic cells, immune function control, and in vivo application for various vaccination systems. The second type of control,that of cell–cell interaction, is important for tissue engineering in order to develop three-dimensional cellular constructs. To achieve in vitro engineering of three-dimensional human tissue constructs, cell–cell interaction must be controlled in three dimensions, but typical biological cell manipulation technique cannot accomplish this task. An engineered cell manipulation technique is necessary. In this book the authors describe the fabrication of nanofilms onto cell surfaces, development of three-dimensional cellular multilayers, and various applications of the cellular multilayers as three-dimensional human models. This important work will be highly informative for researchers and students in the fields of materials science, polymer science, biomaterials, medicinal science, nanotechnology, biotechnology, and biology.
