Author: Adrian T. Sumner
Publisher: John Wiley & Sons
ISBN: 0470695226
Category : Science
Languages : en
Pages : 304
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Book Description
Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.
Author: Bernard John
Publisher: Oxford University Press, USA
ISBN:
Category : Science
Languages : en
Pages : 188
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Book Description
Author: Bernard John
Publisher:
ISBN:
Category : Chromosomes
Languages : en
Pages : 171
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Book Description
Author: R.C. Sobti
Publisher: Springer
ISBN: 9789401003353
Category : Science
Languages : en
Pages : 238
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Book Description
It was at the end of the 19th century that a Swiss biologist, Karl Nageli first proposed the existence of hereditary organelles that carried information from parent to offspring. Ensuing decades experienced vigorous studies that led to the development of discovery that chromosomes are indeed the carriers of genetic information. Subsequent studies, especially by Morgan and Bridges, established unequivocally the chromosome theory of inheritance. Today, the structure of chromosome is well established. At the physical level, eukaryotic chromosomes are composed of a single, linear, double helix of DNA. The elementary helical structure involves nucleosomes, comprised of histones around which the DNA is wrapped. A hierarchy of higher order of chromosomal architecture may possibly be responsible for the regulation of gene helical structures expression. The localized condensations of DNA constitute chromomeres. Uncoiled structures sometimes extending from chromomeres, which form loops, is the result of discontinuities in the regular coiling of the DNA in the chromosome.
Author: Bernard John
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 188
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Book Description
Introduction - Nuleus and chromosome; Chromosome architecture; Epigenetic activities; Phylogenetic functions; Conclusion - the chromosome as a genetic mechanism.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: R.C. Sobti
Publisher: Springer Science & Business Media
ISBN: 9780792370574
Category : Medical
Languages : en
Pages : 266
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Book Description
This volume is a compilation of twenty articles written by scientists from different parts of the world dealing with various aspects of repetitive sequences in chromosomes, telomeric sequences and their maintenance by telomerase, chromatin structure and gene activation, centrometric complexity in holocentric chromosomes, translocation frequencies in X and Y chromosomes and evolution of DNA repair mechanisms, cytogenetics of certain groups of animals viz. lepidoptera, fishes and birds, and radiosensitivity as an indicator of predisposition to breast cancer. The molecular genetics of various cancers viz., gastrointestinal, lung, prostate, and bladder is also discussed.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038405
Category : Science
Languages : en
Pages : 128
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Book Description
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author: Oren Solomon HARMAN
Publisher: Harvard University Press
ISBN: 0674038339
Category : Biography & Autobiography
Languages : en
Pages : 342
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Book Description
Born by mistake, or connivance, to struggling parents in a small Lancashire cotton town in 1903, an uninspired Darlington inadvertently escaped the obscurity of farming life and rose instead, against all odds, to become within a few short years the world's greatest expert on chromosomes, and one of the most penetrating biological thinkers of the twentieth century. Harman follows Darlington's path from bleak prospects to world fame, showing how, within the most miniscule of worlds, he sought answers to the biggest questions--how species originate, how variation occurs, how Nature, both blind and foreboding, random and insightful, makes her way from deep past to unknown future. But Darlington did not stop there: Chromosomes held within their tiny confines untold, dark truths about man and his culture. This passionate conviction led the once famed Darlington down a path of rebuke, isolation, and finally obscurity. As The Man Who Invented the Chromosome unfolds Darlington's forgotten tale--the Nazi atrocities, the Cold War, the crackpot Lysenko, the molecular revolution, eugenics, Civil Rights, the welfare state, the changing views of man's place in nature, biological determinism--all were interconnected. Just as Darlington's work provoked him to ask questions about the link between biology and culture, his life raises fundamental questions about the link between science and society.
Author: Cipriano Galindo
Publisher: Springer
ISBN: 354072690X
Category : Technology & Engineering
Languages : en
Pages : 178
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Book Description
This book focuses on the performance of mobile robots through the use of multi-hierarchical symbolic representations of the environment. To perform deliberative actions, a robot must possess some symbolic representation of its workspace, but representations of real environments can become so large that they must be conveniently arranged to facilitate and, in some cases, make possible their use. Practical solutions tested on real robots, for example a robotic wheelchair, are provided.
