Cholesterol in Atherosclerosis and Coronary Heart Disease

Cholesterol in Atherosclerosis and Coronary Heart Disease PDF Author: Jean P. Kovala
Publisher: Nova Publishers
ISBN: 9781594543029
Category : Medical
Languages : en
Pages : 282

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Book Description
Cholesterol is a soft, waxy substance found among the lipids (fats) in the bloodstream and in all the body's cells. It's an important part of a healthy body because it's used to form cell membranes, some hormones and is needed for other functions. But a high level of cholesterol in the blood -- hypercholesterolemia -- is a major risk factor for coronary heart disease, which leads to heart attack. Cholesterol and other fats can't dissolve in the blood. They have to be transported to and from the cells by special carriers called lipoproteins. There are several kinds, but the key ones are low-density lipoprotein (LDL) and high-density lipoprotein (HDL) Low-density lipoprotein is the major cholesterol carrier in the blood. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries feeding the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This field is alive with exciting new research in all areas including frontal advances in the areas of managing cholesterol as well as cholesterol lowering drugs. This new book focuses on cholesterol in atherosclerosis and coronary heart disease.

Cholesterol in Atherosclerosis and Coronary Heart Disease

Cholesterol in Atherosclerosis and Coronary Heart Disease PDF Author: Jean P. Kovala
Publisher: Nova Publishers
ISBN: 9781594543029
Category : Medical
Languages : en
Pages : 282

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Book Description
Cholesterol is a soft, waxy substance found among the lipids (fats) in the bloodstream and in all the body's cells. It's an important part of a healthy body because it's used to form cell membranes, some hormones and is needed for other functions. But a high level of cholesterol in the blood -- hypercholesterolemia -- is a major risk factor for coronary heart disease, which leads to heart attack. Cholesterol and other fats can't dissolve in the blood. They have to be transported to and from the cells by special carriers called lipoproteins. There are several kinds, but the key ones are low-density lipoprotein (LDL) and high-density lipoprotein (HDL) Low-density lipoprotein is the major cholesterol carrier in the blood. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries feeding the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This field is alive with exciting new research in all areas including frontal advances in the areas of managing cholesterol as well as cholesterol lowering drugs. This new book focuses on cholesterol in atherosclerosis and coronary heart disease.

Stroke Genetics

Stroke Genetics PDF Author: Hugh S. Markus
Publisher: Oxford Medical Publications
ISBN: 0198515863
Category : Medical
Languages : en
Pages : 362

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Book Description
Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Atherosclerosis and Cardiovascular Disease

Atherosclerosis and Cardiovascular Disease PDF Author: G.C. Descovich
Publisher: Springer Science & Business Media
ISBN: 9400907311
Category : Medical
Languages : en
Pages : 718

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Book Description
The advances in the field of atherosclerosis and cardiovascular disease continue at an increasingly rapid pace and it is an arduous task for those not directly involved to keep up with the latest developments. The papers presented at the 7th Meeting on Atherosclerosis and Cardiovascular Disease, held in Bologna, as part of the Ninth Centenary of the foundation of the University of Bologna, have been collected together here with the aim of providing all the latest information for doctors and research workers concerned with this important branch of medicine. We are pleased to be able to thank all those who joined us in celebrating the oldest university in the world. The scientific contributions, of the highest level, are valid proof of the tradition of exchanging experiences and of the continual up-dating of knowledge in the different sectors of lipid metabolism, genetics, physiopathology, pathological anatomy, bio chemical and clinical diagnosis, diet, pharmacological and non-pharmacological ther apy. The numerous contributions made by authors in the field of epidemiology and the prevention of atherosclerosis were also fundamental since not only research centres but also doctors all over the world are engaged in the battle which was defined by the WHO, twenty-five years ago, as the most important epidemic of the modern age.

Atherosclerosis and Cardiovascular Diseases

Atherosclerosis and Cardiovascular Diseases PDF Author: S. Lenzi
Publisher: Springer Science & Business Media
ISBN: 9400932057
Category : Medical
Languages : en
Pages : 542

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Book Description
Proceeding of the 6th International Meeting, Bologna, Italy.

Atherosclerosis: Diet and Drugs

Atherosclerosis: Diet and Drugs PDF Author: Arnold Eckardstein
Publisher: Springer Science & Business Media
ISBN: 3540276610
Category : Medical
Languages : en
Pages : 808

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Book Description
Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity and mortality also remain high despite successful anti-hypertensive and lipid lowering drug therapies which help to reduce cardiovascular morbidity and mortality by about 30% in both secondary and tertiary prevention settings. This can partly be explained by the increasing life expectancy and growing p- portionofelderly people,especiallyinEuropeandNorthAmerica. Inaddition, the World Health Organization makes the alarming prediction that probably in response to the spreading of western dietary behavior and lack of exercise resulting in an increasing prevalence of diabetes, dyslipidemia and hypert- sion, cardiovascular diseases rather than infectious diseases will become the most frequent cause of death worldwide. This volume of the Handbook of Experimental Pharmacology entitled “Atherosclerosis” is divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.

Coronary Primary Prevention Trial

Coronary Primary Prevention Trial PDF Author:
Publisher:
ISBN:
Category : Coronary heart disease
Languages : en
Pages : 2

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Book Description


Atlas of Atherosclerosis

Atlas of Atherosclerosis PDF Author: Peter W.F Wilson
Publisher: Springer Science & Business Media
ISBN: 1475793103
Category : Medical
Languages : en
Pages : 273

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Book Description
This new edition is an integral source of information covering topics such as newer coronary risk factors, high-density lipoprotein metabolism, lipid-lowering drugs, endothelium and thrombosis in atherogenesis, and contributing risk factors. With over 500 exceptional photographs, diagrams, and charts, each chapter illustrates an important facet of diagnosing and treating this common and often fatal disease.

Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease

Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease PDF Author: Gilbert R Thompson
Publisher: World Scientific
ISBN: 1800613997
Category : Medical
Languages : en
Pages : 247

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Book Description
Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built.The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion.The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.

Cholesterol Lowering in the Patient with Coronary Heart Disease

Cholesterol Lowering in the Patient with Coronary Heart Disease PDF Author:
Publisher:
ISBN:
Category : Blood cholesterol
Languages : en
Pages : 40

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Book Description


Coronary Heart Disease

Coronary Heart Disease PDF Author: George V. Mann
Publisher: Harry Ransom Humanities Research Center
ISBN:
Category : Blood cholesterol
Languages : en
Pages : 172

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Book Description
In this text, an international group of distinguished scientists expose the fallacy and commercial exploitation that has resulted in the developments of, for example, regulatory agencies turning a blind eye to fraudulent claims by manufacturers of margarine, vegetable oil and crisps.