Cholera and the Ecology of Vibrio cholerae PDF Download
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Author: B.S. Drasar
Publisher: Springer Science & Business Media
ISBN: 9400915152
Category : Medical
Languages : en
Pages : 366
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Book Description
Only in recent years has it been revealed that V. cholerae is a normal inhabitant of esturine and riverine waters. This means that even if the disease can be eliminated from human population by vaccines etc. the vibrio will continue to survive independently in the environment. It is likely that the environment is the source of epidemic strains. This is the first book to focus on the implication of these discoveries.
Author: B.S. Drasar
Publisher: Springer Science & Business Media
ISBN: 9400915152
Category : Medical
Languages : en
Pages : 366
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Book Description
Only in recent years has it been revealed that V. cholerae is a normal inhabitant of esturine and riverine waters. This means that even if the disease can be eliminated from human population by vaccines etc. the vibrio will continue to survive independently in the environment. It is likely that the environment is the source of epidemic strains. This is the first book to focus on the implication of these discoveries.
Author: Dhiman Barua
Publisher: Springer Science & Business Media
ISBN: 9780306440779
Category : Medical
Languages : en
Pages : 396
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Book Description
Research on cholera has contributed both to knowledge of the epidemic in particular, and to a broader understanding of the fundamental ways in which cells communicate with each other. This volume presents current knowledge in historical perspective to enable the practitioner to treat cholera in a more effective manner, and to provide a comprehensive review for the researcher.
Author: Rita R. Colwell
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 656
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Book Description
Author: Kaye Wachsmuth
Publisher:
ISBN:
Category : Cholera
Languages : en
Pages : 488
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Book Description
Presents the latest molecular studies of virulence, colonization, gene regulation, and the O1 antigen. Gives an in-depth and analytical approach to the epidemiology of cholera that includes outbreak investigations, case-control studies, and surveillance functions. Describes the molecular approach to epidemiologic problems and questions. Tracks the global spread of cholera by genetically defining individual strains. Addresses possible intervention and prevention strategies, including the latest vaccines, and their public health relevance.
Author: Mohammad Tarequl Islam
Publisher:
ISBN:
Category : Vibrio
Languages : en
Pages : 0
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Book Description
Phylogenomic structuring of the Vibrio cholerae clade is an important area of study in the context of the alarming spike of human morbidities due to environmental pathogens around the world. Even after decades of research, the structuring of natural populations of V. cholerae and its sister species is poorly understood. Ecological and epidemiological importance of the clade shouts for a sound understanding of the phylogenetic relationships and environmental dynamics within the clade in their natural settings. In this thesis, my goal is to answer few broad questions on the biology of the V. cholerae clade: i) How different is the evolutionary trajectory of pathogenic lineages from environmental populations ii) To what extent environmental and biogeographic factors impact the intra-species diversity of the model species: V. cholerae iii) Is our understanding of the phylogeny and ecology of the V. cholerae clade consistent with the inclusion of the recently discovered sister species of V. cholerae from both environmental and clinical settings. To address these questions, I have employed culture-based techniques, phenotypic characterization, high throughput amplicon sequencing, whole genome sequencing, quantitative PCR (qPCR) as well as phylogenetic and taxonomic inference tools. I have found potential signatures in V. cholerae population structure in cholera endemic and non-endemic regions. I have also shown the impact of environmental factors on the intra-species diversity of V. cholerae population naturally occurring in a cholera endemic area. Furthermore, I am describing here the genetic, phylogenetic and biological traits, as well as interaction of a novel sister species with V. cholerae: V. paracholerae sp. nov. Moreover, I delineate the phylogenetic and molecular spectrum of a novel sister species of V. cholerae: V. tarriae, isolated from human and environmental samples only from cholera free locations in the USA. The studies presented herein consolidates the understanding of the natural diversity and ecology of the clade containing V. cholerae and its close relatives at species and sub-species level, which could be a significant stride in our knowledge on this group of microorganisms.
Author: T. Ramamurthy
Publisher: Springer Science & Business Media
ISBN: 1603272658
Category : Medical
Languages : en
Pages : 368
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Book Description
Though cholera is an ancient disease, its perennial occurrence in several parts of the world has attracted many researches to find ways and means to combat the disease. The prevailing seventh pandemic cholera is dominating since 1961, but the dimension of the disease has taken several silhouettes, as the genetic structure and functions of the Vibrio cholerae has changed to a great extent. Several recent studies have shown that transformation of the pathogen at the molecular level has ameliorated several cholera outbreaks and epidemics of with successive new clones of V. cholerae. This comprehensive compilation, written by eminent international researchers reviews the epidemiology of cholera in Africa, Asia, Russia and Latin Americas. The other chapters contributed by acclaimed authors cover various aspects on evolution, polysaccaharide biosynthesis, SXT element, integrons, small molecule signalling systems, flagellar synthesis, filamentous phages, pathogenic role of proteases and hemolysin, and other putative virulence factors. In addition, ecology of V. cholerae and management of cholera were also discussed in detail. This book will be good source of information to all researchers with interests in infectious diseases, microbiology and molecular biology.
Author: Christopher John Miller
Publisher:
ISBN:
Category :
Languages : en
Pages : 430
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Book Description
Author: Rita R Colwell
Publisher: Frontiers E-books
ISBN: 288919289X
Category : Microbiology
Languages : en
Pages : 240
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Book Description
Vibrios are Gram-negative bacilli that occur naturally in marine, estuarine, and freshwater systems. Some species include human and animal pathogens capable of causing gastroenteritis, wound infections, cholera, and fatal septicemia. Over the past decades, cutting edge research on Vibrio genomics has promoted a tremendous advance in our knowledge of these pathogens. Significant developments include the discovery of emerging epidemic clones, tracking the spread of new strain variants, and an intensified appreciation of the role of mobile genetic elements in antibiotic resistance spread as well as pathogenesis. Furthermore, improved understanding of the interaction of Vibrios with a variety of living organisms in the aquatic environment has documented the significant role of environmental reservoirs in their seasonal cycle favoring persistence of the pathogen during inter-epidemic periods and enhancing disease transmission. This Research Topic is dedicated to our current understanding in these areas and will bring together leading experts in the field to provide a deep overview of Vibrios ecology and evolution, and will suggest the pathway of future research in this field.
Author: T. Ramamurthy
Publisher: Springer
ISBN: 9781441970800
Category : Medical
Languages : en
Pages : 372
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Book Description
Though cholera is an ancient disease, its perennial occurrence in several parts of the world has attracted many researches to find ways and means to combat the disease. The prevailing seventh pandemic cholera is dominating since 1961, but the dimension of the disease has taken several silhouettes, as the genetic structure and functions of the Vibrio cholerae has changed to a great extent. Several recent studies have shown that transformation of the pathogen at the molecular level has ameliorated several cholera outbreaks and epidemics of with successive new clones of V. cholerae. This comprehensive compilation, written by eminent international researchers reviews the epidemiology of cholera in Africa, Asia, Russia and Latin Americas. The other chapters contributed by acclaimed authors cover various aspects on evolution, polysaccaharide biosynthesis, SXT element, integrons, small molecule signalling systems, flagellar synthesis, filamentous phages, pathogenic role of proteases and hemolysin, and other putative virulence factors. In addition, ecology of V. cholerae and management of cholera were also discussed in detail. This book will be good source of information to all researchers with interests in infectious diseases, microbiology and molecular biology.
Author: S. Kuwahara
Publisher: Springer Science & Business Media
ISBN: 9400967357
Category : Medical
Languages : en
Pages : 293
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Book Description
The United States-Japan Cooperative Medical Science Program was initiated in 1965 by joint agreement between the President of the United States and the Prime Minister of Japan. The purpose of the Program was to promote cooperative biomedical research between the two countries, especially on health problems of recognized impor tance in Asia. Cholera was designated as one topic of mutual interest. Panels of scientists from each country were formed, and these met to select priority areas for research. The Cholera Panels initially defined two major goals: 1) improved and simplified therapy for cholera, and 2) better methods for immunization. Progress in the pursuit of these goals led to the recognition that bacteria other than Vibrio cholerae are also important causes of acute dehydrating diarrhea which resembles cholera in its manifestations and patho genesis; most notable among these are enterotoxinogenic strains of Escherichia coli. Accordingly, panel guidelines were expanded to include all diarrheal diseases that involve fluid loss caused by an enterotoxin. More recently, studies have shown that vibrios, including V. cholerae, have a distinct environmental life cycle that is probably an impor tant factor in the epidemiology of vibrio infections. For this reason, the panel guidelines were again expanded to include studies on the environmental ecology of vibrios. A major project of the Joint Cholera Panels has been the organization and spon sorship of an annual conference on cholera and related diarrheal diseases.
