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Author: Nilashis Nandi
Publisher: CRC Press
ISBN: 1439840024
Category : Medical
Languages : en
Pages : 212
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Book Description
Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.
Author: Nilashis Nandi
Publisher: CRC Press
ISBN: 1439840024
Category : Medical
Languages : en
Pages : 212
Get Book Here
Book Description
Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Chirality in Biological Nanospaces: Reactions in Active Sites.
Author: Nilashis Nandi
Publisher: CRC Press
ISBN: 1040198376
Category : Medical
Languages : en
Pages : 212
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Book Description
Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. Vital life processes occur within the active sites of large biological macromolecules such as proteins, nucleic acids, and lipids. These nanodimensional structures greatly accelerate biological reactions. The chirality of the reactants also has a strong influence on the process, but its importance in such biological reactions has only recently begun to be understood. This book explores the influence of chirality on reaction mechanisms in such biological nanospaces. The text addresses the influence of the chirality of amino acid and sugar in the active sites of transferase, oxidoreductases, hydrolases, lysases, isomerase, ligases, and other systems. It also covers ribosomal architecture.
Author: Pedro Cintas
Publisher: Springer
ISBN: 3642376266
Category : Science
Languages : en
Pages : 318
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Book Description
Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi
Author: F. Richard Keene
Publisher: John Wiley & Sons
ISBN: 1118867319
Category : Science
Languages : en
Pages : 722
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Book Description
Supramolecular chemistry deals with the organisation of molecules into defined assemblies using non-covalent interactions, including weaker and reversible interactions such as hydrogen bonds, and metal-ligand interactions. The aspect of stereochemistry within such chemical architectures, and in particular chirality, is of special interest as it impacts on considerations of molecular recognition, the development of functional materials, the vexed question of homochirality, nanoscale effects of interactions at interfaces, biocatalysis and enzymatic catalysis, and applications in organic synthesis. Chirality in Supramolecular Assemblies addresses many of these aspects, presenting a broad overview of this important and rapidly developing interdisciplinary field. Topics covered include: Origins of molecular and topological chirality Homochirogenesis Chirality in crystallinity Host-guest behavior Chiral influences in functional materials Chirality in network solids and coordination solids Aspects of chirality at interfaces Chirality in organic assemblies Chirality related to biocatalysis and enzymes in organic synthesis. This book is a valuable reference for researchers in the molecular sciences, materials science and biological science working with chiral supramolecular systems. It provides summaries and special insights by acknowledged international experts in the various fields.
Author: Hiroyuki Ohshima
Publisher: John Wiley & Sons
ISBN: 1118542762
Category : Science
Languages : en
Pages : 1188
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Book Description
Diese Enzyklopädie konzentriert sich einzig und allein auf Biokolloide und Biogrenzflächen. Hauptthema sind nicht die wissenschaftlichen Aspekte rund um Kolloide und Grenzflächen. Mit Biokolloiden und Biogrenzflächen beschäftigen sich immer mehr Wissenschaftler, und in dieser Enzyklopädie werden zur Untersuchung von Phänomen in biologischen Systemen "weiche Partikel" und "weiche Grenzflächen" als Oberflächenmodelle herangezogen. - Beschreibt detailliert die grundlegenden Theorien und erläutert die physikalisch-chemischen und theoretischen Aspekte der Biokolloid- und Biogrenzflächenwissenschaft. - Beinhaltet auch eine ausführliche Beschreibung der weichen Grenzflächen und Oberflächen - Beschäftigt sich ebenfalls mit Anwendungen der Grundlagentheorien von Biokolloiden und Biogrenzflächen auf die Nano-, Bio- und Umweltwissenschaften. Ein nützliches Nachschlagewerk genau zur richtigen Zeit, für Forscher und Absolventen im Bereich der Biokolloid- und Biogrenzflächenwissenschaft sowie für Ingenieure der Fachrichtungen.
Author: Katsuhiko Ariga
Publisher: Royal Society of Chemistry
ISBN: 1849734151
Category : Science
Languages : en
Pages : 488
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Book Description
Techniques and strategies for the production of nanomaterials and nanostructures have developed to an advanced level. With contributions from across the globe, this resource presents a broad spectrum of nanomaterials and their applications.
Author: Kazuyoshi Tanaka
Publisher: Newnes
ISBN: 0080982689
Category : Science
Languages : en
Pages : 458
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Book Description
Carbon Nanotubes and Graphene is a timely second edition of the original Science and Technology of Carbon Nanotubes. Updated to include expanded coverage of the preparation, purification, structural characterization, and common application areas of single- and multi-walled CNT structures, this work compares, contrasts, and, where appropriate, unitizes CNT to graphene. This much expanded second edition reference supports knowledge discovery, production of impactful carbon research, encourages transition between research fields, and aids the formation of emergent applications. New chapters encompass recent developments in the theoretical treatments of electronic and vibrational structures, and magnetic, optical, and electrical solid-state properties, providing a vital base to research. Current and potential applications of both materials, including the prospect for large-scale synthesis of graphene, biological structures, and flexible electronics, are also critically discussed. - Updated discussion of properties, structure, and morphology of biological and flexible electronic applications aids fundamental knowledge discovery - Innovative parallel focus on nanotubes and graphene enables you to learn from the successes and failures of, respectively, mature and emergent partner research disciplines - High-quality figures and tables on physical and mathematical applications expertly summarize key information – essential if you need quick, critically relevant data
Author: Joseph John Graham
Publisher:
ISBN:
Category : Foraminifera, Fossil
Languages : en
Pages : 278
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Book Description
Author: Gyula Palyi
Publisher: Elsevier
ISBN: 0080474039
Category : Science
Languages : en
Pages : 445
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Book Description
Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. - This book contains 32 chapters written by Authors, who are leading authorities in the field - Presents the most recent research taking place in this highly challenging field - Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry
